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DOI: 10.1038/bjc.1982.171
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial
Raul C. Urtasun,Michael Feldstein,J Partington,H. Tanasichuk,Jane Miller,Dave Russell,O. Agboola,Bruce Mielke
Glioma
Medicine
Clinical trial
1982
As a continuation of a previous controlled trial using "high-dose" metronidazole as a specific sensitizer of hypoxic cells, we used a more efficient nitroimidazole derivative (misonidazole, MISO) in combination with higher doses of radiation in patients with supratentorial high-grade astrocytomas.Sixty-six patients were stratified according to functional level and histological grading, and randomly allocated within 2 weeks of operation to 1 of 3 therapeutic groups: 1, conventional radiation alone; 2, large fractions of radiation with high-dose metronidazole; and 3, radiation as in Group 2 but with equitoxic doses of MISO.We examined survival as the principal end-point of the study.Neither by increasing the dose of radiation over the previous study, nor by using a more efficient sensitizer, were we able to improve survival over the current conventional daily fractionated radiation.
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“Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial” is a paper by Raul C. Urtasun Michael Feldstein J Partington H. Tanasichuk Jane Miller Dave Russell O. Agboola Bruce Mielke published in 1982. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.