DOI: 10.1038/bjc.1981.64

¤ OpenAccess: Green

This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.

A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma

Norman M. Bleehen,Chris Wiltshire,P N Plowman,Janet Watson,J. R. W. Gleave,Ann Holmes,Walpole Lewin,C. S. Treip,Tanya Hawkins

Misonidazole

Medicine

Astrocytoma

1981

The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail.

Cite this:

Generate Citation

“A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma” is a paper by Norman M. Bleehen Chris Wiltshire P N Plowman Janet Watson J. R. W. Gleave Ann Holmes Walpole Lewin C. S. Treip Tanya Hawkins published in 1981. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.