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DOI: 10.1021/ol8020989
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs
Harinath Chakrapani,Anna Maciąg,Michael L. Citro,Larry K. Keefer,Joseph E. Saavedra
Prodrug
Chemistry
Nitric oxide
2008
Although O2-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.
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“Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs” is a paper by Harinath Chakrapani Anna Maciąg Michael L. Citro Larry K. Keefer Joseph E. Saavedra published in 2008. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.