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DOI: 10.1021/np960416j
OpenAccess: Closed
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Identification of <i>ent</i>-16β,17-Dihydroxykauran-19-oic Acid as an Anti-HIV Principle and Isolation of the New Diterpenoids Annosquamosins A and B from <i>Annona squamosa</i>
Yang Chang Wu,Yu Chun Hung,Fang Rong Chang,Mark Cosentino,Hui Kang Wang,Kuo Hsiung̀ Lee
Phytochemical
Annona squamosa
Stereochemistry
1996
Phytochemical analysis of the fruits of Annona squamosa yielded 12 known kaurane derivatives (1−11, 13) and two new kaurane diterpenoids, which have been named annosquamosin A (16β-hydroxy-17-acetoxy-ent-kauran-19-al) (12) and annosquamosin B (19-nor-ent-kaurane-4α,16β,17-triol) (14). The structures of the new compounds were established by spectral analyses and chemical evidence. Among these 14 compounds, 16β,17-dihydroxy-ent-kauran-19-oic acid (2) showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 μg/mL (therapeutic index >5).
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“Identification of <i>ent</i>-16β,17-Dihydroxykauran-19-oic Acid as an Anti-HIV Principle and Isolation of the New Diterpenoids Annosquamosins A and B from <i>Annona squamosa</i>” is a paper by Yang Chang Wu Yu Chun Hung Fang Rong Chang Mark Cosentino Hui Kang Wang Kuo Hsiung̀ Lee published in 1996. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.