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DOI: 10.1021/la901776a
OpenAccess: Closed
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Glucose-Responsive Micelles from Self-Assembly of Poly(ethylene glycol)-<i>b</i>-Poly(acrylic acid-<i>co</i>-acrylamidophenylboronic acid) and the Controlled Release of Insulin
Beilei Wang,Rujiang Ma,Liangbing Gan,Yan Li,Xiaojun Liu,Yingli An,Linqi Shi
Acrylic acid
Ethylene glycol
Micelle
2009
Poly(ethylene glycol)-block-poly(acrylic acid-co-acrylamidophenylboronic acid) [PEG114-b-(PAA63-co-PAAPBA107)] was synthesized by the modification of poly(ethylene glycol)-block-poly(acrylic acid) (PEG114-b-PAA170) with 3-aminophenylboronic acid (APBA). Glucose-responsive PEG114-b-(PAA63-co-PAAPBA107) self-assembled into core−shell micelles with the hydrophobic core composed of PAAPBA and hydrophilic shell composed of PEG in aqueous solution. The swelling and disaggregating behaviors of micelles responding to glucose were investigated by using light scattering in aqueous solution at pH 7.4. Characterization of insulin-loaded micelles and their drug release in solutions with various glucose concentrations were further studied. The results demonstrated that the drug release rate can be controlled by variation of glucose concentration.
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“Glucose-Responsive Micelles from Self-Assembly of Poly(ethylene glycol)-<i>b</i>-Poly(acrylic acid-<i>co</i>-acrylamidophenylboronic acid) and the Controlled Release of Insulin” is a paper by Beilei Wang Rujiang Ma Liangbing Gan Yan Li Xiaojun Liu Yingli An Linqi Shi published in 2009. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.