DOI: 10.1021/jo1002032

OpenAccess: Closed

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Diastereoselective Synthesis of Hexahydro-3<i>H</i>-pyrrolyzin-3-ones through Pd-Catalyzed Carboamination

Luana Bagnoli,Sandro Cacchi,Giancarlo Fabrizi,Antonella Goggiamani,Catalina Scarponi,Marcello Tiecco

Aryl

Catalysis

Chemistry

2010

The reaction of readily available (5R)-5-but-3-en-1-ylpyrrolidin-2-one with aryl bromides, chlorides, or triflates in the presence of Pd2(dba)3, Xphos, and Cs2CO3 in 1,4-dioxane at 120 °C affords (5R,7aR)-5-aryl hexahydropyrrolizidin-3-ones in good to high yields through a diastereoselective carboamination reaction. Aryl iodides are less successful substrates than bromides and chlorides.

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“Diastereoselective Synthesis of Hexahydro-3<i>H</i>-pyrrolyzin-3-ones through Pd-Catalyzed Carboamination” is a paper by Luana Bagnoli Sandro Cacchi Giancarlo Fabrizi Antonella Goggiamani Catalina Scarponi Marcello Tiecco published in 2010. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.