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DOI: 10.1021/jacs.8b07705
¤ OpenAccess: Green
This work has “Green” OA status. This means it may cost money to access on the publisher landing page, but there is a free copy in an OA repository.
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers
Kali A. Miller,Ephraim G. Morado,Shampa R. Samanta,Brittany A. Walker,Arif Z. Nelson,Samya Sen,Dung T. Tran,Daniel J. Whitaker,Randy H. Ewoldt,Paul V. Braun,Steven C. Zimmerman
Chemistry
Moiety
Hydrolysis
2019
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (p Ka ∼ -10) and acrolein stoichiometrically. Integrating this unit into linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradation with an acid amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer undergoes accelerated rate of degradation and agent release.
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“Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers” is a paper by Kali A. Miller Ephraim G. Morado Shampa R. Samanta Brittany A. Walker Arif Z. Nelson Samya Sen Dung T. Tran Daniel J. Whitaker Randy H. Ewoldt Paul V. Braun Steven C. Zimmerman published in 2019. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.