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DOI: 10.1021/am507798d
OpenAccess: Closed
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Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier
Zhiyuan Xu,Shaojia Zhu,Mingwei Wang,Yongjun Li,Ping Shi,Xiaoyu Huang
Nanocarriers
Materials science
Paclitaxel
2015
Paclitaxel (PTX) is an extensively used potent chemotherapy drug; however, low water solubility, poor bioavailability, and emergence of drug resistance in patients limited its biological application. In this report, we proposed a new drug delivery system for cancer therapy based on graphene oxide (GO), a novel 2D nanomaterial obtained from the oxidation of natural graphite, to improve the utilization rate of PTX. PTX was first connected to biocompatible 6-armed poly(ethylene glycol), followed by covalent introduction into the surface of GO sheets via a facile amidation process under mild conditions, affording the drug delivery system, GO-PEG-PTX (size 50–200 nm). GO-PEG nanosized carrier could quickly enter into human lung cancer A549 and human breast cancer MCF-7 cells verified by inverted fluorescence microscope using fluorescein isothiocyanate as probe. This nanocarrier was nontoxic to A549 and MCF-7 cells without linking with PTX. Nevertheless, GO-PEG-PTX showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system based on PEGylated GO may find widespread application in biomedicine.
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“Delivery of Paclitaxel Using PEGylated Graphene Oxide as a Nanocarrier” is a paper by Zhiyuan Xu Shaojia Zhu Mingwei Wang Yongjun Li Ping Shi Xiaoyu Huang published in 2015. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.