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The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

Pete H. Hutson,Eleftheria N. Finger,Brian C. Magliaro,Sean M. Smith,Antonella Converso,Philip E.J. Sanderson,Deborra Mullins,Lynn A. Hyde,Benjamin K. Eschle,Zara Turnbull,Hazel L. Sloan,M. Guzzi,X. Zhang,A. Wang,Diane Rindgen,Robert Mazzola,Jeffrey A. Vivian,Donnie Eddins,Jason M. Uslaner,Rodney A. Bednar,Carlo J. Gambone,W. Le-Mair,Michael J. Marino,Nancy A. Sachs,Guangwei Xu,Sophie Parmentier-Batteur

Long-term potentiation

Spontaneous alternation

Hippocampal formation

2011

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“The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents” is a paper by Pete H. Hutson Eleftheria N. Finger Brian C. Magliaro Sean M. Smith Antonella Converso Philip E.J. Sanderson Deborra Mullins Lynn A. Hyde Benjamin K. Eschle Zara Turnbull Hazel L. Sloan M. Guzzi X. Zhang A. Wang Diane Rindgen Robert Mazzola Jeffrey A. Vivian Donnie Eddins Jason M. Uslaner Rodney A. Bednar Carlo J. Gambone W. Le-Mair Michael J. Marino Nancy A. Sachs Guangwei Xu Sophie Parmentier-Batteur published in 2011. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.