ϟ
 
DOI: 10.1016/j.cell.2018.03.022
¤ OpenAccess: Hybrid
This work has “Hybrid” OA status. This means it is free under an open license in a toll-access journal.

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Katherine A. Hoadley,Christina Yau,Toshinori Hinoue,Denise M. Wolf,Alexander J. Lazar,Esther Drill,Ronglai Shen,Alison M. Taylor,Andrew D. Cherniack,Vésteinn Thórsson,Rehan Akbani,Reanne Bowlby,Christopher Wong,Maciej Wiznerowicz,Francisco Sanchez‐Vega,A. Gordon Robertson,Barbara Schneider,Michael S. Lawrence,Houtan Noushmehr,Tathiane M Malta,Samantha J. Caesar-Johnson,John A. Demchok,Ina Felau,Melpomeni Kasapi,Martin L. Ferguson,Carolyn M. Hutter,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Jiashan Zhang,Sudha Chudamani,Jia Liu,Laxmi Lolla,Rashi Naresh,Todd Pihl,Qiang Sun,Yunhu Wan,Ye Wu,Juok Cho,Timothy DeFreitas,Scott Frazer,Nils Gehlenborg,Gad Getz,David I. Heiman,Jaegil Kim,Pei Lin,Sam Meier,Michael S. Noble,Gordon Saksena,Doug Voet,Hailei Zhang,Brady Bernard,Nyasha Chambwe,Varsha Dhankani,Theo Knijnenburg,Roger Kramer,Kalle Leinonen,Yuexin Liu,Michael Miller,Sheila M. Reynolds,Ilya Shmulevich,Wei Zhang,Bradley M. Broom,Apurva M. Hegde,Ju Zhang,Rupa S. Kanchi,Anil Korkut,Jun Li,Han Liang,Shiyun Ling,Wenbin Liu,Yiling Lu,Gordon B. Mills,Kwok Shing Ng,Arvind Rao,Michael Ryan,Jing Wang,John N. Weinstein,Jiexin Zhang,Adam Abeshouse,Joshua Armenia,Debyani Chakravarty,Walid K. Chatila,Ino de Bruijn,Jianjiong Gao,Benjamin Groß,Zachary J. Heins,Ritika Kundra,Konnor La,Marc Ladanyi,Augustin Luna,Moriah G. Nissan,Angelica Ochoa,Sarah Phillips,Ed Reznik,Chris Sander,Nikolaus Schultz,Robert P. Sheridan,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Jioajiao Wang,Hongxin Zhang,Pavana Anur,Myron Peto,Paul T. Spellman,Christopher C. Benz,Joshua M. Stuart,D. Neil Hayes,Joel S. Parker,Matthew D. Wilkerson,Adrian Ally,Miruna Balasundaram,Denise Brooks,Rebecca Carlsen,Eric Chuah,Noreen Dhalla,Robert A. Holt,Steven Jones,Katayoon Kasaian,Darlene Lee,Yussanne Ma,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Karen Mungall,Sara Sadeghi,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Kane Tse,Tina Wong,Ashton C. Berger,Rameen Beroukhim,Carrie Cibulskis,Stacey Gabriel,Galen F. Gao,Gavin Ha,Matthew Meyerson,Steven E. Schumacher,Juliann Shih,Melanie Kucherlapati,Raju Kucherlapati,Stephen B. Baylin,Leslie Cope,Ludmila Danilova,Moiz S. Bootwalla,Phillip H. Lai,Dennis T. Maglinte,David J. Van Den Berg,Daniel J. Weisenberger,J. Todd Auman,Saianand Balu,Tom Bodenheimer,Cheng Fan,Alan P. Hoyle,Stuart R. Jefferys,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Lisle E. Mose,Amy H. Perou,Charles M. Perou,Jeffrey Roach,Yan Shi,Janae V. Simons,Tara Skelly,Matthew G. Soloway,Donghui Tan,Umadevi Veluvolu,Huihui Fan,Peter W. Laird,Hui Shen,Wanding Zhou,Michelle Bellair,Kyle Chang,Kyle R. Covington,Chad J. Creighton,Huyen Dinh,Harshavardhan Doddapaneni,Lawrence A. Donehower,Jennifer Drummond,Richard A. Gibbs,Robert Glenn,Walker Hale,Yi Han,Jianhong Hu,Viktoriya Korchina,Sandra Lee,Lora Lewis,Wei Li,Xiuping Liu,Margaret Morgan,Donna Morton,Donna M. Muzny,Jireh Santibanez,Margi Sheth,Eve Shinbrot,Linghua Wang,Min Wang,David A. Wheeler,Xi Liu,Fengmei Zhao,Julian M. Hess,Elizabeth L. Appelbaum,Matthew H. Bailey,Matthew G. Cordes,Ding Li,Catrina C. Fronick,Lucinda A. Fulton,Robert S. Fulton,Cyriac Kandoth,Elaine R. Mardis,Michael D. McLellan,Christopher A. Miller,Heather Schmidt,Richard K. Wilson,Daniel Crain,Erin Curley,Johanna Gardner,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,Troy Shelton,Mark E. Sherman,Eric M. Thompson,Peggy Yena,Jay Bowen,Julie M. Gastier‐Foster,Mark Gerken,Kristen Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Lisa Wise,Erik Zmuda,Niall M. Corcoran,Tony Costello,Christopher M. Hovens,André Lopes Carvalho,Ana Carolina de Carvalho,José Humberto Tavares Guerreiro Fregnani,Adhemar Longatto‐Filho,Rui Manuel Reis,Cristovam Scapulatempo‐Neto,Henrique C. S. Silveira,Daniel Onofre Vidal,Andrew Burnette,Jennifer Eschbacher,Beth Hermes,Ardene Noss,Rosy Singh,Matthew L. Anderson,Patricia Castro,Michael Ittmann,David G. Huntsman,Bernard Kohl,Xuan Le,Richard Thorp,Chris Andry,Elizabeth Duffy,Vladimir Lyadov,Oxana Paklina,Galiya Setdikova,А. В. Шабунин,М. М. Тавобилов,Christopher McPherson,Ronald E. Warnick,Ross S. Berkowitz,Daniel W. Cramer,Colleen M. Feltmate,Neil S. Horowitz,Adam S. Kibel,Michael G. Muto,Chandrajit P. Raut,Andrei Malykh,Jill S. Barnholtz‐Sloan,Wendi Barrett,Karen Devine,Jordonna Fulop,Quinn T. Ostrom,Kristen Shimmel,Yingli Wolinsky,Andrew E. Sloan,Agostino Maria De Rose,Felice Giuliante,Marc T. Goodman,Beth Y. Karlan,Curt H. Hagedorn,John Eckman,Jodi Harr,Jerome Myers,Kelinda Tucker,Leigh Anne Zach,Brenda Deyarmin,Hai Hu,Leonid Kvecher,Caroline Larson,Richard J. Mural,Stella Somiari,Aleš Vícha,Tomáš Zelinka,Joseph Bennett,Mary Iacocca,Brenda Rabeno,Patricia Swanson,Mathieu Latour,Louis Lacombe,Bernard Têtu,Alain Bergeron,Mary McGraw,Susan M. Staugaitis,John A. Chabot,Hanina Hibshoosh,Antonia R. Sepulveda,Tao Su,Yichen Wang,Olga Potapova,Olga Voronina,Laurence Desjardins,Odette Mariani,Sergio Román-Román,Xavier Sastre,Marc Henri Stern,Feixiong Cheng,Sabina Signoretti,Andrew Berchuck,Darell D. Bigner,Eric Lipp,Jeffrey R. Marks,Shannon J. McCall,Roger E. McLendon,Angeles Alvarez Secord,Alexis Sharp,Madhusmita Behera,Daniel J. Brat,Amy Chen,Keith A. Delman,Seth D. Force,Fadlo R. Khuri,Kelly R. Magliocca,Shishir K. Maithel,Jeffrey J. Olson,Taofeek K. Owonikoko,Alan Pickens,Suresh S. Ramalingam,Dong Min Shin,Gabriel L. Sica,Erwin G. Van Meir,Hongzheng Zhang,Wil Eijckenboom,Ad J. M. Gillis,Esther Korpershoek,Leendert Looijenga,Wolter Oosterhuis,Hans Stoop,Kim E. van Kessel,Ellen C. Zwarthoff,Chiara Calatozzolo,Lucia Cuppini,Stefania Cuzzubbo,Francesco DiMeco,Gaetano Finocchiaro,Luca Mattei,Alessandro Perin,Bianca Pollo,Chu Chen,J. R. Houck,Pawadee Lohavanichbutr,Arndt Hartmann,Christine Stoehr,Robert Stoehr,Helge Täubert,Sven Wach,Bernd Wullich,Witold Kycler,Dawid Murawa,Ki Wung Chung,William J. Edenfield,Julie Martin,Éric Baudin,Glenn J. Bubley,Raphael Bueno,Assunta De Rienzo,William G. Richards,Steven N. Kalkanis,Tom Mikkelsen,Lisa Scarpace,Nicolas Girard,Marta Aymerich,Elı́as Campo,Eva Giné,Armando López Guillermo,Nguyễn Văn Bang,Phan Thi Hanh,Bui Duc Phu,Yufang Tang,Howard Colman,Kimberley Evason,Peter R. Dottino,John A. Martignetti,Hani Gabra,Hartmut Juhl,Teniola Akeredolu,Serghei Stepa,Dave Hoon,Keunsoo Ahn,Koo Jeong Kang,Felix Beuschlein,Anne Breggia,Michael J. Birrer,Debra A. Bell,Mitesh J. Borad,Alan H. Bryce,Erik P. Castle,Vishal S. Chandan,John C. Cheville,John A. Copland,Michael B. Farnell,Thomas J. Flotte,Nasra H. Giama,Thai H. Ho,Michael L. Kendrick,Jean Pierre A. Kocher,Karla Kopp,Catherine D. Moser,David M. Nagorney,Daniel R. O’Brien,Brian P. O’Neill,Tushar Patel,Gloria M. Petersen,Florencia G. Que,Michael Rivera,Lewis R. Roberts,Robert C. Smallridge,Thomas C. Smyrk,Melissa L. Stanton,R. Houston Thompson,Michael Torbenson,Ju Dong Yang,Lizhi Zhang,Fadi Brimo,Jaffer A. Ajani,Ana Maria Angulo Gonzalez,Carmen Behrens,olanta Bondaruk,Russell R. Broaddus,Bogdan Czerniak,Bita Esmaeli,Junya Fujimoto,Jeffrey E. Gershenwald,Charles Guo,Christopher J. Logothetis,Funda Meric‐Bernstam,César A. Moran,Lois M. Ramondetta,David C. Rice,Anil K. Sood,Pheroze Tamboli,Timothy C. Thompson,Patricia Troncoso,Anne S. Tsao,Ignacio Wistuba,Candace Carter,Lauren E. Haydu,Peter Hersey,Valerie Jakrot,Hojabr Kakavand,Richard Kefford,Kenneth Lee,Georgina V. Long,Graham J. Mann,Michael J. Quinn,Robyn P.M. Saw,Richard A. Scolyer,Kerwin F. Shannon,Andrew J. Spillane,Jonathan R. Stretch,Maria Synott,John F. Thompson,James S. Wilmott,Hikmat Al‐Ahmadie,Timothy A. Chan,Ronald Ghossein,Anuradha Gopalan,Douglas A. Levine,Victor E. Reuter,Samuel Singer,Bhuvanesh Singh,Nguyen Viet Tien,Thomas Broudy,Cyrus Mirsaidi,Praveen Nair,Paul Drwiega,Judy Miller,Jennifer A. Smith,Howard Zaren,Joong-Won Park,Nguyễn Phi Hùng,Electron Kebebew,W. Marston Linehan,Adam R. Metwalli,Karel Pacák,Peter A. Pinto,Mark Schiffman,Laura S. Schmidt,Cathy D. Vocke,Nicolas Wentzensen,Robert A. Worrell,Hannah Yang,Marc Moncrieff,Chandra Goparaju,Jonathan Melamed,Harvey I. Pass,Natalia Botnariuc,Irina Caraman,Mircea Cernat,Inga Chemencedji,Adrian Clipca,Serghei Doruc,Ghenadie Gorincioi,Sergiu Mura,Maria Pirtac,Irina Stancul,Diana Tcaciuc,Monique Albert,Iakovina Alexopoulou,Angel Arnaout,John M.S. Bartlett,Jay Engel,Sébastien Gilbert,Jeremy Parfitt,Harman S. Sekhon,George V. Thomas,Doris M. Rassl,Robert C. Rintoul,Carlo Bifulco,Raina A. Tamakawa,Walter J. Urba,Nicholas K. Hayward,H. Th. Marc Timmers,Anna Antenucci,Francesco Facciolo,Gian Luca Grazi,Mirella Marino,Roberta Merola,Ronald R. de Krijger,A.-P. Gimenez-Roqueplo,Alain Piché,Simone Chevalier,Ginette McKercher,Kıvanç Birsoy,Gene H. Barnett,Cathy Brewer,Carol Farver,Theresa Naska,Nathan A. Pennell,Daniel P. Raymond,Cathy Schilero,Kathy Smolenski,Cecilia Williams,Carl Morrison,Jeffrey A. Borgia,Michael J. Liptay,Mark Pool,Christopher W. Seder,Kerstin Junker,Larsson Omberg,Mikhail Dinkin,George Manikhas,Domenico Alvaro,Maria Consiglia Bragazzi,Vincenzo Cardinale,Guido Carpino,Eugenio Gaudio,David Chesla,Sandra Cottingham,Michael Dubina,Fedor Moiseenko,Renumathy Dhanasekaran,Karl‐Friedrich Becker,Klaus-Peter Janssen,Julia Slotta‐Huspenina,Mohamed H. Abdel‐Rahman,Dina Aziz,Sue Bell,Colleen M. Cebulla,Amy Davis,Rebecca Duell,J. Bradley Elder,Joe Hilty,Bahavna Kumar,James C. Lang,Norman L. Lehman,Randy Mandt,Phuong Nguyen,Robert Pilarski,Karan Rai,Lynn Schoenfield,Kelly Senecal,Paul E. Wakely,Paul Hansen,Ronald M. Lechan,James F. Powers,Arthur S. Tischler,William E. Grizzle,Katherine C. Sexton,Alison Kastl,Joel Henderson,Sima P. Porten,Jens Waldmann,Martin Fassnacht,L. Sylvia,Dirk Schadendorf,Marta Couce,Markus Graefen,Hartwig Huland,Guido Sauter,Thorsten Schlomm,Ronald Simon,Pierre Tennstedt,Oluwole Olabode,Mark A. Nelson,Oliver F. Bathe,Peter R. Carroll,June M. Chan,Philip J. DiSaia,Pat Glenn,Robin K. Kelley,Charles N. Landen,Joanna Phillips,Michael Prados,Jeffry P. Simko,Karen Smith‐McCune,Scott R. VandenBerg,Kevin K. Roggin,Ashley Fehrenbach,Ady Kendler,Suzanne Sifri,Ruth Steele,Antonio Jimeno,Francis A. Carey,Ian Forgie,Massimo Mannelli,Michael E. Carney,Brenda Hernandez,Benito Campos,Christel Herold‐Mende,Christin Jungk,Andreas Unterberg,Andreas von Deimling,Aaron Bossler,Joseph Galbraith,Laura Jacobus,Michael Knudson,Tina Knutson,Deqin Ma,Mohammed Milhem,Rita D. Sigmund,Andrew K. Godwin,Rashna Madan,Howard G. Rosenthal,Clement Adebamowo,Sally N. Adebamowo,Alex Boussioutas,David G. Beer,Thomas J. Giordano,Anne Marie Mes-Masson,Fred Saad,Thèrése Bocklage,Lisa M. Landrum,Robert S. Mannel,Kathleen Moore,Katherine Moxley,Russel Postier,Joan Walker,Rosemary E. Zuna,Michael D. Feldman,Federico Valdivieso,Rajiv Dhir,James D. Luketich,Edna M. Mora Pinero,Mario Quintero-Aguilo,Carlos Gilberto Carlotti,José Sebastião dos Santos,Rafael Kemp,Ajith Sankarankuty,Daniela Pretti da Cunha Tirapelli,James W.F. Catto,Kathy Agnew,Elizabeth M. Swisher,Jenette Creaney,Bruce Robinson,Carl Simon Shelley,Eryn M. Godwin,S. DiSean Kendall,Cassaundra Shipman,Carol R. Bradford,Thomas E. Carey,Andrea Haddad,Jeffey Moyer,Lisa A. Peterson,Mark E. Prince,Laura S. Rozek,Gregory T. Wolf,Rayleen V. Bowman,Kwun M. Fong,Ian A. Yang,Robert J. Korst,W. Kimryn Rathmell,J. Leigh Fantacone-Campbell,Jeffrey A. Hooke,Albert J. Kovatich,Craig D. Shriver,John F. DiPersio,Bettina F. Drake,Ramaswamy Govindan,Sharon E. Heath,Timothy J. Ley,Brian A. Van Tine,Peter Westervelt,Mark A. Rubin,Jung Il Lee,Natália Del Angelo Aredes,Armaz Mariamidze,Christopher C. Benz

Biology
DNA methylation
Cancer
2018
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.
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    Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer” is a paper by Katherine A. Hoadley Christina Yau Toshinori Hinoue Denise M. Wolf Alexander J. Lazar Esther Drill Ronglai Shen Alison M. Taylor Andrew D. Cherniack Vésteinn Thórsson Rehan Akbani Reanne Bowlby Christopher Wong Maciej Wiznerowicz Francisco Sanchez‐Vega A. Gordon Robertson Barbara Schneider Michael S. Lawrence Houtan Noushmehr Tathiane M Malta Samantha J. Caesar-Johnson John A. Demchok Ina Felau Melpomeni Kasapi Martin L. Ferguson Carolyn M. Hutter Heidi J. Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C. Zenklusen Jiashan Zhang Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Juok Cho Timothy DeFreitas Scott Frazer Nils Gehlenborg Gad Getz David I. Heiman Jaegil Kim Pei Lin Sam Meier Michael S. Noble Gordon Saksena Doug Voet Hailei Zhang Brady Bernard Nyasha Chambwe Varsha Dhankani Theo Knijnenburg Roger Kramer Kalle Leinonen Yuexin Liu Michael Miller Sheila M. Reynolds Ilya Shmulevich Wei Zhang Bradley M. Broom Apurva M. Hegde Ju Zhang Rupa S. Kanchi Anil Korkut Jun Li Han Liang Shiyun Ling Wenbin Liu Yiling Lu Gordon B. Mills Kwok Shing Ng Arvind Rao Michael Ryan Jing Wang John N. Weinstein Jiexin Zhang Adam Abeshouse Joshua Armenia Debyani Chakravarty Walid K. Chatila Ino de Bruijn Jianjiong Gao Benjamin Groß Zachary J. Heins Ritika Kundra Konnor La Marc Ladanyi Augustin Luna Moriah G. Nissan Angelica Ochoa Sarah Phillips Ed Reznik Chris Sander Nikolaus Schultz Robert P. Sheridan S. Onur Sumer Yichao Sun Barry S. Taylor Jioajiao Wang Hongxin Zhang Pavana Anur Myron Peto Paul T. Spellman Christopher C. Benz Joshua M. Stuart D. Neil Hayes Joel S. Parker Matthew D. Wilkerson Adrian Ally Miruna Balasundaram Denise Brooks Rebecca Carlsen Eric Chuah Noreen Dhalla Robert A. Holt Steven Jones Katayoon Kasaian Darlene Lee Yussanne Ma Marco A. Marra Michael Mayo Richard A. Moore Andrew J. Mungall Karen Mungall Sara Sadeghi Jacqueline E. Schein Payal Sipahimalani Angela Tam Nina Thiessen Kane Tse Tina Wong Ashton C. Berger Rameen Beroukhim Carrie Cibulskis Stacey Gabriel Galen F. Gao Gavin Ha Matthew Meyerson Steven E. Schumacher Juliann Shih Melanie Kucherlapati Raju Kucherlapati Stephen B. Baylin Leslie Cope Ludmila Danilova Moiz S. Bootwalla Phillip H. Lai Dennis T. Maglinte David J. Van Den Berg Daniel J. Weisenberger J. Todd Auman Saianand Balu Tom Bodenheimer Cheng Fan Alan P. Hoyle Stuart R. Jefferys Corbin D. Jones Shaowu Meng Piotr A. Mieczkowski Lisle E. Mose Amy H. Perou Charles M. Perou Jeffrey Roach Yan Shi Janae V. Simons Tara Skelly Matthew G. Soloway Donghui Tan Umadevi Veluvolu Huihui Fan Peter W. Laird Hui Shen Wanding Zhou Michelle Bellair Kyle Chang Kyle R. Covington Chad J. Creighton Huyen Dinh Harshavardhan Doddapaneni Lawrence A. Donehower Jennifer Drummond Richard A. Gibbs Robert Glenn Walker Hale Yi Han Jianhong Hu Viktoriya Korchina Sandra Lee Lora Lewis Wei Li Xiuping Liu Margaret Morgan Donna Morton Donna M. Muzny Jireh Santibanez Margi Sheth Eve Shinbrot Linghua Wang Min Wang David A. Wheeler Xi Liu Fengmei Zhao Julian M. Hess Elizabeth L. Appelbaum Matthew H. Bailey Matthew G. Cordes Ding Li Catrina C. Fronick Lucinda A. Fulton Robert S. Fulton Cyriac Kandoth Elaine R. Mardis Michael D. McLellan Christopher A. Miller Heather Schmidt Richard K. Wilson Daniel Crain Erin Curley Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Candace Shelton Troy Shelton Mark E. Sherman Eric M. Thompson Peggy Yena Jay Bowen Julie M. Gastier‐Foster Mark Gerken Kristen Leraas Tara M. Lichtenberg Nilsa C. Ramirez Lisa Wise Erik Zmuda Niall M. Corcoran Tony Costello Christopher M. Hovens André Lopes Carvalho Ana Carolina de Carvalho José Humberto Tavares Guerreiro Fregnani Adhemar Longatto‐Filho Rui Manuel Reis Cristovam Scapulatempo‐Neto Henrique C. S. Silveira Daniel Onofre Vidal Andrew Burnette Jennifer Eschbacher Beth Hermes Ardene Noss Rosy Singh Matthew L. Anderson Patricia Castro Michael Ittmann David G. Huntsman Bernard Kohl Xuan Le Richard Thorp Chris Andry Elizabeth Duffy Vladimir Lyadov Oxana Paklina Galiya Setdikova А. В. Шабунин М. М. Тавобилов Christopher McPherson Ronald E. Warnick Ross S. Berkowitz Daniel W. Cramer Colleen M. Feltmate Neil S. Horowitz Adam S. Kibel Michael G. Muto Chandrajit P. Raut Andrei Malykh Jill S. Barnholtz‐Sloan Wendi Barrett Karen Devine Jordonna Fulop Quinn T. Ostrom Kristen Shimmel Yingli Wolinsky Andrew E. Sloan Agostino Maria De Rose Felice Giuliante Marc T. Goodman Beth Y. Karlan Curt H. Hagedorn John Eckman Jodi Harr Jerome Myers Kelinda Tucker Leigh Anne Zach Brenda Deyarmin Hai Hu Leonid Kvecher Caroline Larson Richard J. Mural Stella Somiari Aleš Vícha Tomáš Zelinka Joseph Bennett Mary Iacocca Brenda Rabeno Patricia Swanson Mathieu Latour Louis Lacombe Bernard Têtu Alain Bergeron Mary McGraw Susan M. Staugaitis John A. Chabot Hanina Hibshoosh Antonia R. Sepulveda Tao Su Yichen Wang Olga Potapova Olga Voronina Laurence Desjardins Odette Mariani Sergio Román-Román Xavier Sastre Marc Henri Stern Feixiong Cheng Sabina Signoretti Andrew Berchuck Darell D. Bigner Eric Lipp Jeffrey R. Marks Shannon J. McCall Roger E. McLendon Angeles Alvarez Secord Alexis Sharp Madhusmita Behera Daniel J. Brat Amy Chen Keith A. Delman Seth D. Force Fadlo R. Khuri Kelly R. Magliocca Shishir K. Maithel Jeffrey J. Olson Taofeek K. Owonikoko Alan Pickens Suresh S. Ramalingam Dong Min Shin Gabriel L. Sica Erwin G. Van Meir Hongzheng Zhang Wil Eijckenboom Ad J. M. Gillis Esther Korpershoek Leendert Looijenga Wolter Oosterhuis Hans Stoop Kim E. van Kessel Ellen C. Zwarthoff Chiara Calatozzolo Lucia Cuppini Stefania Cuzzubbo Francesco DiMeco Gaetano Finocchiaro Luca Mattei Alessandro Perin Bianca Pollo Chu Chen J. R. Houck Pawadee Lohavanichbutr Arndt Hartmann Christine Stoehr Robert Stoehr Helge Täubert Sven Wach Bernd Wullich Witold Kycler Dawid Murawa Ki Wung Chung William J. Edenfield Julie Martin Éric Baudin Glenn J. Bubley Raphael Bueno Assunta De Rienzo William G. Richards Steven N. Kalkanis Tom Mikkelsen Lisa Scarpace Nicolas Girard Marta Aymerich Elı́as Campo Eva Giné Armando López Guillermo Nguyễn Văn Bang Phan Thi Hanh Bui Duc Phu Yufang Tang Howard Colman Kimberley Evason Peter R. Dottino John A. Martignetti Hani Gabra Hartmut Juhl Teniola Akeredolu Serghei Stepa Dave Hoon Keunsoo Ahn Koo Jeong Kang Felix Beuschlein Anne Breggia Michael J. Birrer Debra A. Bell Mitesh J. Borad Alan H. Bryce Erik P. Castle Vishal S. Chandan John C. Cheville John A. Copland Michael B. Farnell Thomas J. Flotte Nasra H. Giama Thai H. Ho Michael L. Kendrick Jean Pierre A. Kocher Karla Kopp Catherine D. Moser David M. Nagorney Daniel R. O’Brien Brian P. O’Neill Tushar Patel Gloria M. Petersen Florencia G. Que Michael Rivera Lewis R. Roberts Robert C. Smallridge Thomas C. Smyrk Melissa L. Stanton R. Houston Thompson Michael Torbenson Ju Dong Yang Lizhi Zhang Fadi Brimo Jaffer A. Ajani Ana Maria Angulo Gonzalez Carmen Behrens olanta Bondaruk Russell R. Broaddus Bogdan Czerniak Bita Esmaeli Junya Fujimoto Jeffrey E. Gershenwald Charles Guo Christopher J. Logothetis Funda Meric‐Bernstam César A. Moran Lois M. Ramondetta David C. Rice Anil K. Sood Pheroze Tamboli Timothy C. Thompson Patricia Troncoso Anne S. Tsao Ignacio Wistuba Candace Carter Lauren E. Haydu Peter Hersey Valerie Jakrot Hojabr Kakavand Richard Kefford Kenneth Lee Georgina V. Long Graham J. Mann Michael J. Quinn Robyn P.M. Saw Richard A. Scolyer Kerwin F. Shannon Andrew J. Spillane Jonathan R. Stretch Maria Synott John F. Thompson James S. Wilmott Hikmat Al‐Ahmadie Timothy A. Chan Ronald Ghossein Anuradha Gopalan Douglas A. Levine Victor E. Reuter Samuel Singer Bhuvanesh Singh Nguyen Viet Tien Thomas Broudy Cyrus Mirsaidi Praveen Nair Paul Drwiega Judy Miller Jennifer A. Smith Howard Zaren Joong-Won Park Nguyễn Phi Hùng Electron Kebebew W. Marston Linehan Adam R. Metwalli Karel Pacák Peter A. Pinto Mark Schiffman Laura S. Schmidt Cathy D. Vocke Nicolas Wentzensen Robert A. Worrell Hannah Yang Marc Moncrieff Chandra Goparaju Jonathan Melamed Harvey I. Pass Natalia Botnariuc Irina Caraman Mircea Cernat Inga Chemencedji Adrian Clipca Serghei Doruc Ghenadie Gorincioi Sergiu Mura Maria Pirtac Irina Stancul Diana Tcaciuc Monique Albert Iakovina Alexopoulou Angel Arnaout John M.S. Bartlett Jay Engel Sébastien Gilbert Jeremy Parfitt Harman S. Sekhon George V. Thomas Doris M. Rassl Robert C. Rintoul Carlo Bifulco Raina A. Tamakawa Walter J. Urba Nicholas K. Hayward H. Th. Marc Timmers Anna Antenucci Francesco Facciolo Gian Luca Grazi Mirella Marino Roberta Merola Ronald R. de Krijger A.-P. Gimenez-Roqueplo Alain Piché Simone Chevalier Ginette McKercher Kıvanç Birsoy Gene H. Barnett Cathy Brewer Carol Farver Theresa Naska Nathan A. Pennell Daniel P. Raymond Cathy Schilero Kathy Smolenski Cecilia Williams Carl Morrison Jeffrey A. Borgia Michael J. Liptay Mark Pool Christopher W. Seder Kerstin Junker Larsson Omberg Mikhail Dinkin George Manikhas Domenico Alvaro Maria Consiglia Bragazzi Vincenzo Cardinale Guido Carpino Eugenio Gaudio David Chesla Sandra Cottingham Michael Dubina Fedor Moiseenko Renumathy Dhanasekaran Karl‐Friedrich Becker Klaus-Peter Janssen Julia Slotta‐Huspenina Mohamed H. Abdel‐Rahman Dina Aziz Sue Bell Colleen M. Cebulla Amy Davis Rebecca Duell J. Bradley Elder Joe Hilty Bahavna Kumar James C. Lang Norman L. Lehman Randy Mandt Phuong Nguyen Robert Pilarski Karan Rai Lynn Schoenfield Kelly Senecal Paul E. Wakely Paul Hansen Ronald M. Lechan James F. Powers Arthur S. Tischler William E. Grizzle Katherine C. Sexton Alison Kastl Joel Henderson Sima P. Porten Jens Waldmann Martin Fassnacht L. Sylvia Dirk Schadendorf Marta Couce Markus Graefen Hartwig Huland Guido Sauter Thorsten Schlomm Ronald Simon Pierre Tennstedt Oluwole Olabode Mark A. Nelson Oliver F. Bathe Peter R. Carroll June M. Chan Philip J. DiSaia Pat Glenn Robin K. Kelley Charles N. Landen Joanna Phillips Michael Prados Jeffry P. Simko Karen Smith‐McCune Scott R. VandenBerg Kevin K. Roggin Ashley Fehrenbach Ady Kendler Suzanne Sifri Ruth Steele Antonio Jimeno Francis A. Carey Ian Forgie Massimo Mannelli Michael E. Carney Brenda Hernandez Benito Campos Christel Herold‐Mende Christin Jungk Andreas Unterberg Andreas von Deimling Aaron Bossler Joseph Galbraith Laura Jacobus Michael Knudson Tina Knutson Deqin Ma Mohammed Milhem Rita D. Sigmund Andrew K. Godwin Rashna Madan Howard G. Rosenthal Clement Adebamowo Sally N. Adebamowo Alex Boussioutas David G. Beer Thomas J. Giordano Anne Marie Mes-Masson Fred Saad Thèrése Bocklage Lisa M. Landrum Robert S. Mannel Kathleen Moore Katherine Moxley Russel Postier Joan Walker Rosemary E. Zuna Michael D. Feldman Federico Valdivieso Rajiv Dhir James D. Luketich Edna M. Mora Pinero Mario Quintero-Aguilo Carlos Gilberto Carlotti José Sebastião dos Santos Rafael Kemp Ajith Sankarankuty Daniela Pretti da Cunha Tirapelli James W.F. Catto Kathy Agnew Elizabeth M. Swisher Jenette Creaney Bruce Robinson Carl Simon Shelley Eryn M. Godwin S. DiSean Kendall Cassaundra Shipman Carol R. Bradford Thomas E. Carey Andrea Haddad Jeffey Moyer Lisa A. Peterson Mark E. Prince Laura S. Rozek Gregory T. Wolf Rayleen V. Bowman Kwun M. Fong Ian A. Yang Robert J. Korst W. Kimryn Rathmell J. Leigh Fantacone-Campbell Jeffrey A. Hooke Albert J. Kovatich Craig D. Shriver John F. DiPersio Bettina F. Drake Ramaswamy Govindan Sharon E. Heath Timothy J. Ley Brian A. Van Tine Peter Westervelt Mark A. Rubin Jung Il Lee Natália Del Angelo Aredes Armaz Mariamidze Christopher C. Benz published in 2018. It has an Open Access status of “hybrid”. You can read and download a PDF Full Text of this paper here.