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Epithelial-Mesenchymal Transitions

Yibin Kang,Joan Massagué

Biology

Epithelial–mesenchymal transition

Mesenchymal stem cell

2004

Epithelial-mesenchymal transitions (EMT) are vital for morphogenesis during embryonic development and are also implicated in the conversion of early stage tumors into invasive malignancies. Several key inducers of EMT are transcription factors that repress E-cadherin expression. A recent report in Cell (Yang et al. 2004Yang J. Mani S.A. Donaher J.L. Ramaswamy S. Itzykson R.A. Come C. Savagner P. Gitelman I. Richardson A. Weinberg R.A. Cell. 2004; 117: 927-939Abstract Full Text Full Text PDF PubMed Scopus (2884) Google Scholar) adds Twist to this list and links EMT to the ability of breast cancer cells to enter the circulation and seed metastases.

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“Epithelial-Mesenchymal Transitions” is a paper by Yibin Kang Joan Massagué published in 2004. It has an Open Access status of “hybrid”. You can read and download a PDF Full Text of this paper here.