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Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation

Randall A. Meyer,Joel Sunshine,Karlo Perica,Alyssa K. Kosmides,Kent Aje,Jonathan P. Schneck,Jordan J. Green

Antigen

Immune system

Antigen-presenting cell

2015

Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.

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“Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation” is a paper by Randall A. Meyer Joel Sunshine Karlo Perica Alyssa K. Kosmides Kent Aje Jonathan P. Schneck Jordan J. Green published in 2015. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.