Polymer‐Protected Sub‐2‐nm‐Nanogap Fabrication for Biological Sensing in Near‐Physiological Conditions

SmallVolume 5, Issue 24 p. 2797-2801 Communication Polymer-Protected Sub-2-nm-Nanogap Fabrication for Biological Sensing in Near-Physiological Conditions† Huijuan Zhang, Huijuan Zhang Advanced Materials for Micro- and Nano-Systems Program Singapore–MIT Alliance 117576 (Singapore)Search for more papers by this authorRobert J. Barsotti, Robert J. Barsotti Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)Search for more papers by this authorChee-Leong Wong, Chee-Leong Wong Centre for IC Failure Analysis and Reliability Department of Electrical & Computer Engineering National University of Singapore 4 Engineering Drive 3, 117576 (Singapore)Search for more papers by this authorXuejia Xue, Xuejia Xue Department of Chemistry National University of Singapore 117543 (Singapore)Search for more papers by this authorXiaogang Liu, Xiaogang Liu Department of Chemistry National University of Singapore 117543 (Singapore)Search for more papers by this authorFrancesco Stellacci, Francesco Stellacci Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)Search for more papers by this authorJohn T. L. Thong, Corresponding Author John T. L. Thong [email protected] Department of Electrical and Computer Engineering National University of Singapore 117576 (Singapore)Department of Electrical and Computer Engineering National University of Singapore 117576 (Singapore).Search for more papers by this author Huijuan Zhang, Huijuan Zhang Advanced Materials for Micro- and Nano-Systems Program Singapore–MIT Alliance 117576 (Singapore)Search for more papers by this authorRobert J. Barsotti, Robert J. Barsotti Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)Search for more papers by this authorChee-Leong Wong, Chee-Leong Wong Centre for IC Failure Analysis and Reliability Department of Electrical & Computer Engineering National University of Singapore 4 Engineering Drive 3, 117576 (Singapore)Search for more papers by this authorXuejia Xue, Xuejia Xue Department of Chemistry National University of Singapore 117543 (Singapore)Search for more papers by this authorXiaogang Liu, Xiaogang Liu Department of Chemistry National University of Singapore 117543 (Singapore)Search for more papers by this authorFrancesco Stellacci, Francesco Stellacci Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge, MA 02139 (USA)Search for more papers by this authorJohn T. L. Thong, Corresponding Author John T. L. Thong [email protected] Department of Electrical and Computer Engineering National University of Singapore 117576 (Singapore)Department of Electrical and Computer Engineering National University of Singapore 117576 (Singapore).Search for more papers by this author First published: 14 December 2009 https://doi.org/10.1002/smll.200900938Citations: 15 † This work is supported by the Singapore–MIT Alliance and the National University of Singapore. H. Zhang is grateful to the Singapore–MIT Alliance for support through a fellowship. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Polymer-protected sub-2-nm nanogaps that are fabricated via a novel electrical stressing approach exhibit substantial ionic-current reduction in near-physiological conditions. These devices enable direct DNA detection in aqueous solution by utilizing assembly of oligonucleotide-modified gold nanoparticles to the nanogap (see image). Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description smll_200900938_sm_supplfigs.pdf376.5 KB supplfigs Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume5, Issue24December 18, 2009Pages 2797-2801 RelatedInformation