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The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells

Sun-Woong Kang,Byung‐Hyun Cha,Honghyun Park,Kwang-Sook Park,Kuen Yong Lee,Soo−Hong Lee

Adipogenesis

Adipose tissue

Self-healing hydrogels

2011

The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin α1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.

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“The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells” is a paper by Sun-Woong Kang Byung‐Hyun Cha Honghyun Park Kwang-Sook Park Kuen Yong Lee Soo−Hong Lee published in 2011. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.