Resveratrol production at large scale using plant cell suspensions

Resveratrol and its derivatives are a class of polyphenolic compounds recognized for their outstanding biological properties based on clinical trials. In addition, their possible uses in nutraceutics, cosmetics, and as pharmaceutics create a need for large‐scale production with the possibility to use sustainable sources. In this review, we report on the biotechnological production of resveratrol and some of its derivatives through plant cell suspensions, such as grapevine cell culture systems. These cultures usually need elicitation. Methyljasmonate, cyclodextrins, the combination of both and chitosan are the elicitors leading to the best responses in terms of resveratrol amounts produced in flasks. Production performances of resveratrol can be optimized in flasks for scale‐up in large culture volumes. We summarize the plant cell culture systems used for resveratrol bioproduction and transfer experiments from flasks to bioreactors as well as elicitor‐mediated upregulation of the defense genes in those plant culture systems.