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KlenTaq DNA Polymerase Adopts Unique Recognition States when Encountering Matched, Mismatched, and Abasic Template Sites: An NMR Study

Bastian Holzberger,M. Gabriele Pszolla,Andreas Marx,Heiko M. Möller

DNA polymerase

Polymerase

DNA

2012

On the tracks of a DNA polymerase: NMR provides insights into DNA synthesis in a virtually label-free manner and under close-to-physiological conditions. Through the monitoring of the chemical-shift changes of multiple 13C-methyl methionine residues we found unique recognition states for canonical and noncanonical cases, thus indicating enzymatic cycling through distinct paths.

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“KlenTaq DNA Polymerase Adopts Unique Recognition States when Encountering Matched, Mismatched, and Abasic Template Sites: An NMR Study” is a paper by Bastian Holzberger M. Gabriele Pszolla Andreas Marx Heiko M. Möller published in 2012. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.