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DOI: 10.1002/anie.201302557
OpenAccess: Closed
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A Controlled‐Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery
Zilong Zhao,Hong-Min Meng,Nannan Wang,Michael Donovan,Ting Fu,Mingxu You,Zhuo Chen,Xiaobing Zhang,Weihong Tan
Nanocarriers
Drug delivery
Mesoporous silica
2013
This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).
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“A Controlled‐Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery” is a paper by Zilong Zhao Hong-Min Meng Nannan Wang Michael Donovan Ting Fu Mingxu You Zhuo Chen Xiaobing Zhang Weihong Tan published in 2013. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.