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Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation

Lichen Yin,Ziyuan Song,Qiuhao Qu,Kyung Hoon Kim,Nan Zheng,Chia-Yu Yao,Isthier Chaudhury,Haoyu Tang,Nathan P. Gabrielson,Fatih M. Uckun,Jianjun Cheng

Tumor necrosis factor alpha

Lipopolysaccharide

Gene silencing

2013

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set of rationally designed components that collectively facilitate efficient intestinal absorption of siRNA and induce potent TNF-α silencing in macrophages. Single gavage of SSNPs in mice depletes systemic TNF-α production at an siRNA dose as low as 50 μg kg−1, and thus protects mice from lipopolysaccharide-induced hepatic injury.

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“Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation” is a paper by Lichen Yin Ziyuan Song Qiuhao Qu Kyung Hoon Kim Nan Zheng Chia-Yu Yao Isthier Chaudhury Haoyu Tang Nathan P. Gabrielson Fatih M. Uckun Jianjun Cheng published in 2013. It has an Open Access status of “green”. You can read and download a PDF Full Text of this paper here.