Consecutive Formation of G‐Quadruplexes in Human Telomeric‐Overhang DNA: A Protective Capping Structure for Telomere Ends

The end of the line: Structural studies demonstrate the consecutive formation of G-quadruplexes in human single-stranded telomeric-overhang DNA. A higher-order DNA G-quadruplex structure was found to protect DNA double-strand ends from being recognized as double-strand breaks and to direct against nuclease hydrolysis, suggesting that the superhelix structure may provide protective “capping” for the telomere ends. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.