Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature

Angewandte Chemie International EditionVolume 48, Issue 38 p. 7094-7097 Communication Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature† Wang Zhou, Wang Zhou State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297Search for more papers by this authorLiangren Zhang Dr., Liangren Zhang Dr. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297Search for more papers by this authorNing Jiao Dr., Ning Jiao Dr. jiaoning@bjmu.edu.cn State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297 State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (China)Search for more papers by this author Wang Zhou, Wang Zhou State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297Search for more papers by this authorLiangren Zhang Dr., Liangren Zhang Dr. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297Search for more papers by this authorNing Jiao Dr., Ning Jiao Dr. jiaoning@bjmu.edu.cn State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191 (China), Fax: (+86) 10-8280-5297 State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (China)Search for more papers by this author First published: 01 September 2009 https://doi.org/10.1002/anie.200903838Citations: 213 † Financial support from Peking University, the National Science Foundation of China (nos. 20702002, 20872003), and the National Basic Research Program of China (973 Program; grant no. 2009CB825300) is greatly appreciated. We thank Chun Zhang for reproducing the results of entries 4 and 9 in Table 2. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Three CH bonds are cleaved in the direct transformation of methyl arenes to aryl nitriles under mild and neutral conditions (see scheme). This new synthetic tool may not only be used to construct synthetically and medicinally important aryl nitriles, it also achieves CH functionalization under mild conditions. PIDA=phenyliodonium diacetate. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200903838_sm_miscellaneous_information.pdf2.9 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume48, Issue38September 7, 2009Pages 7094-7097 RelatedInformation