Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification

Angewandte Chemie International EditionVolume 48, Issue 37 p. 6849-6852 Communication Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification† Wei Xu, Wei Xu Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorXuejia Xue, Xuejia Xue Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorTianhu Li Prof., Tianhu Li Prof. Division of Chemistry & Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)Search for more papers by this authorHuaqiang Zeng Prof., Huaqiang Zeng Prof. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorXiaogang Liu Prof., Xiaogang Liu Prof. [email protected] Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this author Wei Xu, Wei Xu Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorXuejia Xue, Xuejia Xue Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorTianhu Li Prof., Tianhu Li Prof. Division of Chemistry & Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore)Search for more papers by this authorHuaqiang Zeng Prof., Huaqiang Zeng Prof. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this authorXiaogang Liu Prof., Xiaogang Liu Prof. [email protected] Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (65) 6779-1691Search for more papers by this author First published: 26 August 2009 https://doi.org/10.1002/anie.200901772Citations: 355 † We acknowledge the DSTA (R-143-000-379), Singapore-MIT Alliance, and A*STAR (SERC 082-101-0026) for supporting this work. X.L. is grateful to the National University of Singapore for a Start-Up Grant Award (R-143-000-317) and a Young Investigator Award (R-143-000-318). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract One–two punch: Single stranded DNA sequences can be detected by nicking endonuclease assisted nanoparticle amplification (see picture). The detection system offers a colorimetric detection limit of 0.5 fmol within hours for selected oligonucleotides. Detection of DNA sequences with a single base mismatch or different lengths is also demonstrated. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_200901772_sm_miscellaneous_information.pdf239.9 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 1aJ. G. Hacia, L. C. Brody, M. S. Chee, S. P. A. Fodor, F. S. Collins, Nat. Genet. 1996, 14, 441; 1bF. S. Santiago, A. V. Todd, N. J. Hawkins, R. L. Ward, Mol. Cell. Probes 1997, 11, 33. 2 2aK. Wang, Z. Tang, C. J. Yang, Y. Kim, X. Fang, W. Li, Y. Wu, C. D. Medley, Z. Cao, J. Li, P. Colon, H. Lin, W. Tan, Angew. Chem. 2009, 121, 870; Angew. Chem. Int. Ed. 2009, 48, 856; 2bE. Socher, L. Bethge, A. Knoll, N. Jungnick, A. Herrmann, O. Seitz, Angew. Chem. 2008, 120, 9697; Angew. Chem. Int. Ed. 2008, 47, 9555; 2cD. Baumstark, H.-A. Wagenknecht, Angew. Chem. 2008, 120, 2652; Angew. Chem. Int. Ed. 2008, 47, 2612; 2dT. N. Grossmann, L. Röglin, O. Seitz, Angew. Chem. 2007, 119, 5315; Angew. Chem. Int. Ed. 2007, 46, 5223; 2eL. Lee, C. Connell, W. Bloch, Nucleic Acids Res. 1993, 21, 3761; 2fS. Tyagi, F. R. Kramer, Nat. Biotechnol. 1996, 14, 303. 3 3aD. G. Thompson, A. Enright, K. Faulds, W. E. Smith, D. Graham, Anal. Chem. 2008, 80, 2805; 3bM. Cho, M. S. Han, C. Ban, Chem. Commun. 2008, 4573; 3cN. L. Rosi, C. A. Mirkin, Chem. Rev. 2005, 105, 1547; 3dH. Li, L. Rothberg, Proc. Natl. Acad. Sci. USA 2004, 101, 14036; 3eK. Sato, K. Hosokawa, M. Maeda, J. Am. Chem. Soc. 2003, 125, 8102; 3fR. A. Reynolds, C. A. Mirkin, R. L. Letsinger, J. Am. Chem. Soc. 2000, 122, 3795; 3gJ. J. Storhoff, C. A. Mirkin, Chem. Rev. 1999, 99, 1849; 3hJ. J. Storhoff, R. Elghanian, R. C. Mucic, C. A. Mirkin, R. L. Letsinger, J. Am. Chem. Soc. 1998, 120, 1959; 3iR. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, C. A. Mirkin, Science 1997, 277, 1078; 3jC. A. Mirkin, R. L. Letsinger, R. C. Mucic, J. J. Storhoff, Nature 1996, 382, 607. 4A four-component sandwich assay format was also examined for colorimetric DNA detection (see the Supporting Information). The low sensitivity obtained is probably due to inefficient cleavage of the linker strand from inhomogeneous nicking reactions by particle probe aggregation. 5 5aY. Xu, K. D. Lunnen, H. Kong, Proc. Natl. Acad. Sci. USA 2001, 98, 12990; 5bJ. Li, Y. Chu, Y. H. B. Lee, X. S. Xie, Nucleic Acids Res. 2008, 36, e 36; 5cT. Kiesling, K. Cox, E. A. Davidson, K. Dretechen, G. Grater, S. Hibbard, R. S. Lasken, J. Leshin, E. Skowronski, M. Danielsen, Nucleic Acids Res. 2007, 35, e 117; 5dE. Tan, B. Erwin, S. Dames, T. Ferguson, M. Buechel, B. Irvine, K. Voelkerding, A. Niemz, Biochemistry 2008, 47, 9987. 6 6aQ. Dai, X. Liu, J. Coutts, L. Austin, Q. Huo, J. Am. Chem. Soc. 2008, 130, 8138; 6bA. Numnuam, K. Y. C. Torres, Y. Xiang, R. Bash, P. Thavarungkul, P. Kanatharana, E. Pretsch, J. Wang, E. Bakker, J. Am. Chem. Soc. 2008, 130, 410; 6cA. Barhoumi, D. Zhang, F. Tam, N. J. Halas, J. Am. Chem. Soc. 2008, 130, 5523; 6dJ. Zhang, S. Song, L. Zhang, L. Wang, H. Wu, D. Pan, C. Fan, J. Am. Chem. Soc. 2006, 128, 8575; 6eG. Braun, S. J. Lee, M. Dante, T. Q. Nguyen, M. Moskovits, R. Reich, J. Am. Chem. Soc. 2007, 129, 6378; 6fS. Fang, H. J. Lee, A. W. Wark, R. M. Corn, J. Am. Chem. Soc. 2006, 128, 14044; 6gJ. J. Storhoff, A. D. Lucas, V. Garimella, Y. P. Bao, U. R. Muller, Nat. Biotechnol. 2004, 22, 883; 6hY. C. Cao, R. Jin, C. A. Mirkin, Science 2002, 297, 1536; 6iS. J. Park, T. A. Taton, C. A. Mirkin, Science 2002, 295, 1503; 6jL. He, M. D. Musick, S. R. Nicewarner, F. G. Salina, S. J. Benkovic, M. J. Natan, C. D. Keating, J. Am. Chem. Soc. 2000, 122, 9071; 6kT. A. Taton, C. A. Mirkin, R. L. Letsinger, Science 2000, 289, 1757; 6lF. Qiu, D. Jiang, Y. Ding, J. Zhu, L. Huang, Angew. Chem. 2008, 120, 5087; Angew. Chem. Int. Ed. 2008, 47, 5009; 6mL. Chu, R. Förch, W. Knoll, Angew. Chem. 2007, 119, 5032; Angew. Chem. Int. Ed. 2007, 46, 4944; 6nD. M. Hammond, A. Manetto, J. Gierlich, V. A. Azov, P. M. E. Gramlich, G. A. Burley, M. Maul, T. Carell, Angew. Chem. 2007, 119, 4262; Angew. Chem. Int. Ed. 2007, 46, 4184; 6oS. Shrestha, C. M. Y. Yueng, C. E. Mills, J. Lewington, S. C. Tsang, Angew. Chem. 2007, 119, 3929; Angew. Chem. Int. Ed. 2007, 46, 3855; 6pK. Faulds, F. Mckenzie, W. E. Smith, D. Graham, Angew. Chem. 2007, 119, 1861; Angew. Chem. Int. Ed. 2007, 46, 1829; 6qX. Xu, D. G. Georganopoulou, H. D. Hill, C. A. Mirkin, Anal. Chem. 2007, 79, 6650. 7 7aD. B. Robinson, H. H. J. Persson, H. Zeng, G. Li, N. Pourmand, S. Sun, S. X. Wang, Langmuir 2005, 21, 3096; 7bI. L. Medintz, H. T. Uyeda, E. R. Goldman, H. Mattoussi, Nat. Mater. 2005, 4, 435; 7cC.-Y. Zhang, H.-C. Yeh, M. T. Kuroki, T.-H. Wang, Nat. Mater. 2005, 4, 826; 7dP. Zhang, S. Rogelj, K. Nguyen, D. Wheeler, J. Am. Chem. Soc. 2006, 128, 12410; 7eH. Mai, Y. Zhang, R. Si, L. You, C. Yan, J. Am. Chem. Soc. 2006, 128, 6426; 7fJ. C. Boyer, F. Vetrone, L. A. Cuccia, J. A. Capobianco, J. Am. Chem. Soc. 2006, 128, 7444; 7gO. Ehlert, R. Thomann, M. Darbandi, T. Nann, ACS Nano 2008, 2, 120; 7hF. Wang, X. Xue, X. Liu, Angew. Chem. 2008, 120, 920; Angew. Chem. Int. Ed. 2008, 47, 906; 7iF. Wang, X. Liu, J. Am. Chem. Soc. 2008, 130, 5642–5643; 7jC. Jiang, F. Wang, N. Wu, X. Liu, Adv. Mater. 2008, 20, 4826; 7kY. Liu, W. Luo, R. Li, G. Liu, M. R. Antonio, X. Chen, J. Phys. Chem. C 2008, 112, 686; 7lM. Yu, F. Li, Z. Chen, H. Hu, C. Zhan, H. Yang, C. Huang, Anal. Chem. 2009, 81, 930; 7mC. Dong, F. C. J. M. Van Veggel, ACS Nano 2009, 3, 123; 7nF. Wang, X. Liu, Chem. Soc. Rev. 2009, 38, 976. 8 8aY. Lu, J. Liu, Acc. Chem. Res. 2007, 40, 315; 8bJ. Liu, Y. Lu, J. Am. Chem. Soc. 2007, 129, 8634; 8cH. Lee, Z. Wang, J. Liu, Y. Lu, J. Am. Chem. Soc. 2008, 130, 14217; 8dR. Liu, R. Liew, J. Zhou, B. Xing, Angew. Chem. 2007, 119, 8955; Angew. Chem. Int. Ed. 2007, 46, 8799; 8eX. Xue, F. Wang, X. Liu, J. Am. Chem. Soc. 2008, 130, 3244; 8fG. Zheng, W. L. Daniel, C. A. Mirkin, J. Am. Chem. Soc. 2008, 130, 9644; 8gV. Pavlov, Y. Xiao, B. Shlyahovsky, I. Willner, J. Am. Chem. Soc. 2004, 126, 11768; 8hJ.-M. Nam, C. S. Thaxton, C. A. Mirkin, Science 2003, 301, 1884; 8iC. D. Medley, J. E. Smith, Z. Tang, Y. Wu, S. Bamrungsap, W. Tan, Anal. Chem. 2008, 80, 1067; 8jS. He, D. Li, C. Zhu, S. Song, L. Wang, Y. Long, C. Fan, Chem. Commun. 2008, 4885. 9X. Liu, X. Li, T. Zhou, Y. Wang, T. T. Ng, W. Xu, T. Li, Chem. Commun. 2008, 380. Citing Literature Volume48, Issue37September 1, 2009Pages 6849-6852 ReferencesRelatedInformation