R. Bellan

Low-Gain Avalanche Diodes (LGAD) are silicon detectors with output signals that are about a factor of 10 larger than those of traditional sensors. In this paper we analyze how the design of LGAD can be optimized to exploit their increased output signal to reach optimum timing performances. Our simulations show that these sensors, the so-called Ultra-Fast Silicon Detectors (UFSD), will be able to reach a time resolution factor of 10 better than that of traditional silicon sensors.

There are many possibilities for new physics beyond the Standard Model that feature non-standard Higgs sectors. These may introduce new sources of CP violation, and there may be mixing between multiple Higgs bosons or other new scalar bosons. Alternatively, the Higgs may be a composite state, or there may even be no Higgs at all. These non-standard Higgs scenarios have important implications for collider physics as well as for cosmology, and understanding their phenomenology is essential for a full comprehension of electroweak symmetry breaking. This report discusses the most relevant theories which go beyond the Standard Model and its minimal, CP-conserving supersymmetric extension: two-Higgs-doublet models and minimal supersymmetric models with CP violation, supersymmetric models with an extra singlet, models with extra gauge groups or Higgs triplets, Little Higgs models, models in extra dimensions, and models with technicolour or other new strong dynamics. For each of these scenarios, this report presents an introduction to the phenomenology, followed by contributions on more detailed theoretical aspects and studies of possible experimental signatures at the LHC and other colliders.

This document summarises the talks and discussions happened during the VBSCan Split17 workshop, the first general meeting of the VBSCan COST Action network. This collaboration is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

We present a parton-level study of electro-weak production of vector-boson pairs at the Large Hadron Collider, establishing the sensitivity to a set of dimension-six operators in the Standard Model Effective Field Theory (SMEFT). Different final states are statistically combined, and we discuss how the orthogonality and interdependence of different analyses must be considered to obtain the most stringent constraints. The main novelties of our study are the inclusion of SMEFT effects in non-resonant diagrams and in irreducible QCD backgrounds, and an exhaustive template analysis of optimal observables for each operator and process considered. We also assess for the first time the sensitivity of vector-boson-scattering searches in semileptonic final states.

The HERA electron--proton collider has collected 100 pb$^{-1}$ of data since its start-up in 1992, and recently moved into a high-luminosity operation mode, with upgraded detectors, aiming to increase the total integrated luminosity per experiment to more than 500 pb$^{-1}$. HERA has been a machine of excellence for the study of QCD and the structure of the proton. The Large Hadron Collider (LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will be completed at CERN in 2007. The main mission of the LHC is to discover and study the mechanisms of electroweak symmetry breaking, possibly via the discovery of the Higgs particle, and search for new physics in the TeV energy scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC will also make a substantial number of precision measurements and will offer a new regime to study the strong force via perturbative QCD processes and diffraction. For the full LHC physics programme a good understanding of QCD phenomena and the structure function of the proton is essential. Therefore, in March 2004, a one-year-long workshop started to study the implications of HERA on LHC physics. This included proposing new measurements to be made at HERA, extracting the maximum information from the available data, and developing/improving the theoretical and experimental tools. This report summarizes the results achieved during this workshop.

There are many possibilities for new physics beyond the Standard Model that feature non-standard Higgs sectors. These may introduce new sources of CP violation, and there may be mixing between multiple Higgs bosons or other new scalar bosons. Alternatively, the Higgs may be a composite state, or there may even be no Higgs at all. These non-standard Higgs scenarios have important implications for collider physics as well as for cosmology, and understanding their phenomenology is essential for a full comprehension of electroweak symmetry breaking. This report discusses the most relevant theories which go beyond the Standard Model and its minimal, CP-conserving supersymmetric extension: two-Higgs-doublet models and minimal supersymmetric models with CP violation, supersymmetric models with an extra singlet, models with extra gauge groups or Higgs triplets, Little Higgs models, models in extra dimensions, and models with technicolour or other new strong dynamics. For each of these scenarios, this report presents an introduction to the phenomenology, followed by contributions on more detailed theoretical aspects and studies of possible experimental signatures at the LHC and other colliders.

The powerful muon and tracker systems of the CMS detector together with dedicated reconstruction software allow precise and efficient measurement of muon tracks originating from proton-proton collisions. The standard muon reconstruction algorithms, however, are inadequate to deal with muons that do not originate from collisions. This note discusses the design, implementation, and performance results of a dedicated cosmic muon track reconstruction algorithm, which features pattern recognition optimized for muons that are not coming from the interaction point, i.e., cosmic muons and beam-halo muons. To evaluate the performance of the new algorithm, data taken during Cosmic Challenge phases I and II were studied and compared with simulated cosmic data. In addition, a variety of more general topologies of cosmic muons and beam-halo muons were studied using simulated data to demonstrate some key features of the new algorithm.

The HERA electron--proton collider has collected 100 pb$^{-1}$ of data since its start-up in 1992, and recently moved into a high-luminosity operation mode, with upgraded detectors, aiming to increase the total integrated luminosity per experiment to more than 500 pb$^{-1}$. HERA has been a machine of excellence for the study of QCD and the structure of the proton. The Large Hadron Collider (LHC), which will collide protons with a centre-of-mass energy of 14 TeV, will be completed at CERN in 2007. The main mission of the LHC is to discover and study the mechanisms of electroweak symmetry breaking, possibly via the discovery of the Higgs particle, and search for new physics in the TeV energy scale, such as supersymmetry or extra dimensions. Besides these goals, the LHC will also make a substantial number of precision measurements and will offer a new regime to study the strong force via perturbative QCD processes and diffraction. For the full LHC physics programme a good understanding of QCD phenomena and the structure function of the proton is essential. Therefore, in March 2004, a one-year-long workshop started to study the implications of HERA on LHC physics. This included proposing new measurements to be made at HERA, extracting the maximum information from the available data, and developing/improving the theoretical and experimental tools. This report summarizes the results achieved during this workshop.

Two drift tubes (DTs) chambers of the CMS muon barrel system were exposed to a 40 MHz bunched muon beam at the CERN SPS, and for the first time the whole CMS Level-1 DTs-based trigger system chain was tested. Data at different energies and inclination angles of the incident muon beam were collected, as well as data with and without an iron absorber placed between the two chambers, to simulate the electromagnetic shower development in CMS. Special data-taking runs were dedicated to test for the first time the Track Finder system, which reconstructs track trigger candidates by performing a proper matching of the muon segments delivered by the two chambers. The present paper describes the results of these measurements.

The MIP Timing Detector will provide additional timing capabilities for detection of minimum ionizing particles (MIPs) at CMS during the High Luminosity LHC era, improving event reconstruction and pileup rejection. The central portion of the detector, the Barrel Timing Layer (BTL), will be instrumented with LYSO:Ce crystals and Silicon Photomultipliers (SiPMs) providing a time resolution of about 30 ps at the beginning of operation, and degrading to 50-60 ps at the end of the detector lifetime as a result of radiation damage. In this work, we present the results obtained using a 120 GeV proton beam at the Fermilab Test Beam Facility to measure the time resolution of unirradiated sensors. A proof-of-concept of the sensor layout proposed for the barrel region of the MTD, consisting of elongated crystal bars with dimensions of about 3 x 3 x 57 mm$^3$ and with double-ended SiPM readout, is demonstrated. This design provides a robust time measurement independent of the impact point of the MIP along the crystal bar. We tested LYSO:Ce bars of different thickness (2, 3, 4 mm) with a geometry close to the reference design and coupled to SiPMs manufactured by Hamamatsu and Fondazione Bruno Kessler. The various aspects influencing the timing performance such as the crystal thickness, properties of the SiPMs (e.g. photon detection efficiency), and impact angle of the MIP are studied. A time resolution of about 28 ps is measured for MIPs crossing a 3 mm thick crystal bar, corresponding to an MPV energy deposition of 2.6 MeV, and of 22 ps for the 4.2 MeV MPV energy deposition expected in the BTL, matching the detector performance target for unirradiated devices.

The barrel region of the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider is instrumented with Drift Tube (DT) detectors. This paper describes in full details the calibration of the DT hit reconstruction algorithm. After inter-channel synchronization has been verified through the appropriate hardware procedure, the time pedestals are extracted directly from the distribution of the recorded times. Further corrections for time-of-flight and time of signal propagation are applied as soon as the three-dimensional hit position within the DT chamber is known. The different effects of the time pedestal miscalibration on the two main hit reconstruction algorithms are shown. The drift velocity calibration algorithm is based on the meantimer technique. Different meantimer relations for different track angles and patterns of hit cells are used. This algorithm can also be used to determine the uncertainty on the reconstructed hit position.

This note describes the local reconstruction in the Drift Tube subdetector of the CMS muon subsystem. The local reconstruction is the sequence of steps leading from the TDC measurements to reconstructed three-dimensional segments inside each DT chamber. These segments are the input to the muon track reconstruction. This note updates and supersedes CMS NOTE 2002/043

The development of Low-Gain Avalanche Diodes (LGADs) has made possible to manufacture silicon detectors with output signals that are about a factor of 10 larger than those of traditional sensors.This increased output brings many benefits such as the possibility of developing thin detectors with large enough signals, a good immunity towards low charge collection efficiency and it is key for excellent timing capabilities.In this paper, we report on the development of silicon sensors based on the LGAD design optimized to achieve excellent timing performance, the so-called Ultra-Fast Silicon Detectors (UFSDs).In particular, we demonstrate the possibility of obtaining ultra-fast silicon detectors with time resolution of less than 30 picosecond.

We present the first parton-level study of anomalous effects in triboson production in both fully and semi-leptonic channels in proton-proton collisions at 13 TeV at the Large Hadron Collider (LHC). The sensitivity to anomalies induced by a minimal set of bosonic dimension-6 operators from the Warsaw basis is evaluated with specific analyses for each final state. A likelihood-based strategy is employed to assess the most sensitive kinematic observables per channel, where the contribution of Effective Field Theory operators is parameterized at either the linear or quadratic level. The impact of the mutual interference terms of pairs of operators on the sensitivity is also examined. This benchmark study explores the complementarity and overlap in sensitivity between different triboson measurements and paves the way for future analyses at the LHC experiments. The statistical combination of the considered final states allows setting stringent bounds on five bosonic Wilson coefficients.

A bstract We present the first parton-level study of anomalous effects in triboson production in both fully and semi-leptonic channels in proton-proton collisions at 13 TeV at the Large Hadron Collider (LHC). The sensitivity to anomalies induced by a minimal set of bosonic dimension-6 operators from the Warsaw basis is evaluated with specific analyses for each final state. A likelihood-based strategy is employed to assess the most sensitive kinematic observables per channel, where the contribution of Effective Field Theory operators is parameterized at either the linear or quadratic level. The impact of the mutual interference terms of pairs of operators on the sensitivity is also examined. This benchmark study explores the complementarity and overlap in sensitivity between different triboson measurements and paves the way for future analyses at the LHC experiments. The statistical combination of the considered final states allows setting stringent bounds on five bosonic Wilson coefficients.

Antimicrobial peptides (AMPs) can kill bacteria by disrupting their cytoplasmic membrane, which reduces the tendency of antibacterial resistance compared to conventional antibiotics. Their possible toxicity to human cells, however, limits their applicability. The combination of magnetically controlled drug delivery and supramolecular engineering can help to reduce the dosage of AMPs, control the delivery, and improve their cytocompatibility. Lasioglossin III (LL) is a natural AMP form bee venom that is highly antimicrobial. Here, superparamagnetic iron oxide nanoparticles (IONs) with a supramolecular ureido-pyrimidinone (UPy) coating were investigated as a drug carrier for LL for a controlled delivery to a specific target. Binding to IONs can improve the antimicrobial activity of the peptide. Different transmission electron microscopy (TEM) techniques showed that the particles have a crystalline iron oxide core with a UPy shell and UPy fibers. Cytocompatibility and internalization experiments were carried out with two different cell types, phagocytic and nonphagocytic cells. The drug carrier system showed good cytocompatibility (>70%) with human kidney cells (HK-2) and concentration-dependent toxicity to macrophagic cells (THP-1). The particles were internalized by both cell types, giving them the potential for effective delivery of AMPs into mammalian cells. By self-assembly, the UPy-coated nanoparticles can bind UPy-functionalized LL (UPy-LL) highly efficiently (99%), leading to a drug loading of 0.68 g g-1. The binding of UPy-LL on the supramolecular nanoparticle system increased its antimicrobial activity against E. coli (MIC 3.53 µM to 1.77 µM) and improved its cytocompatible dosage for HK-2 cells from 5.40 µM to 10.6 µM. The system showed higher cytotoxicity (5.4 µM) to the macrophages. The high drug loading, efficient binding, enhanced antimicrobial behavior, and reduced cytotoxicity makes ION@UPy-NH2 an interesting drug carrier for AMPs. The combination with superparamagnetic IONs allows potential magnetically controlled drug delivery and reduced drug amount of the system to address intracellular infections or improve cancer treatment.

Abstract Water‐soluble supramolecular polymers show great potential to develop dynamic biomaterials with tailored properties. Here, we elucidate the morphology, stability and dynamicity of supramolecular polymers derived from bisurea‐based monomers. An accessible synthetic approach from 2,4‐toluene diisocyanate (TDI) as the starting material is developed. TDI has two isocyanates that differ in intrinsic reactivity, which allows to obtain functional, desymmetrized monomers in a one‐step procedure. We explore how the hydrophobic/hydrophilic ratio affects the properties of the formed supramolecular polymers by increasing the number of methylene units from 10 to 12 keeping the hydrophilic hexa(ethylene glycol) constant. All bisurea‐based monomers form long, fibrous structures with 3–5 monomers in the cross‐section in water, indicating a proper hydrophobic\hydrophilic balance. The stability of the supramolecular polymers increases with an increasing amount of methylene units, whereas the dynamic nature of the monomers decreases. The introduction of one Cy3 dye affords modified supramolecular monomers, which co‐assemble with the unmodified monomers into fibrous structures. All systems show excellent water‐compatibility and no toxicity for different cell‐lines. Importantly, in cell culture media, the fibrous structures remain present, highlighting the stability of these supramolecular polymers in physiological conditions. The results obtained here motivate further investigation of these bisurea‐based building blocks as dynamic biomaterial.

This document summarises the talks and discussions happened during the VBSCan Mid-Term Scientific Meeting workshop. The VBSCan COST action is dedicated to the coordinated study of vector boson scattering (VBS) from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

The CMS muon barrel drift tubes system has been recently fully installed and commissioned in the experiment. The performance and the current status of the detector are briefly presented and discussed.

The event display and data quality monitoring visualisation systems are especially crucial for commissioning CMS in the imminent CMS physics run at the LHC. They have already proved invaluable for the CMS magnet test and cosmic challenge. We describe how these systems are used to navigate and filter the immense amounts of complex event data from the CMS detector and prepare clear and flexible views of the salient features to the shift crews and offline users. These allow shift staff and experts to navigate from a top-level general view to very specific monitoring elements in real time to help validate data quality and ascertain causes of problems. We describe how events may be accessed in the higher level trigger filter farm, at the CERN Tier-0 centre, and in offsite centres to help ensure good data quality at all points in the data processing workflow. Emphasis has been placed on deployment issues in order to ensure that experts and general users may use the visualization systems at CERN, in remote operations and monitoring centres offsite, and from their own desktops.

This document reports the first year of activity of the VBSCan COST Action network, as summarised by the talks and discussions happened during the VBSCan Thessaloniki 2018 workshop. The VBSCan COST action is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

The work presented in this thesis covers the description and the performance studies of the muon reconstruction and simulation algorithms which I developed. More specifically: the simulation of the drift tube cell, the muon reconstruction within the DT chamber, the track reconstruction and muon identification with the whole CMS tracking system, are extensively discussed. The final aim of the work here presented was to obtain a high resolution on the observables of the $Z \rightarrow\mu^{+}\mu^{-}$ process, because the presence of the $Z$ particle in the final state is one of the important signatures of the $pp \rightarrow\mu^{+}\mu^{-}jjjj$ vector boson scattering channel. The vector boson scattering processes holds the key to investigate the electroweak symmetry breaking without any assumption on the breaking mechanism. A study of the $pp \rightarrow\mu^{+}\mu^{-}jjjj$ channel has been performed in order to assess the possibility of probing the symmetry breaking mechanism through the $VV$ fusion process using the CMS detector, with no assumption on the mechanism which restores the unitarity.

This document summarises the talks and discussions happened during the VBSCan Mid-Term Scientific Meeting workshop. The VBSCan COST action is dedicated to the coordinated study of vector boson scattering (VBS) from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

The origin of the Dark Matter (DM) is a puzzle that particle physics is trying to understand.Physics at the collider has a unique potentential to produce the DM candidate in laboratory.In this contribution we present the latest results of the searches for DM at the ATLAS and CMS experiments, using √ s = 7 TeV and √ s = 8 TeV data.Emphasis is given to the arguments addressed in the discussion session, in particular on the models used to interpret the experimental results.

The production of massive vector boson pairs is a key process for the understanding of the non-abelian gauge structure of the standard model and for the comprehension of the electroweak symmetry breaking mechanism. The study of the production of vector boson pairs with the presence of two jets in the event allows measuring the electroweak production of vector bosons in association with jets, in particular made up through vector boson scattering (VBS) processes. In this contribution, we presented the recent results of the production of dibosons in association with two jets at $\sqrt{s}$ = 13 TeV.

The muon reconstruction starts at the level of the individual detectors. The results are track segments in the Drift Tube (DT) and in the Cathode Strip Chamber (CSC), and 3D points in the Resistive Plate Chamber (RPC). The information coming from each muon sub-detector are combined using the Kalman filter technique and the tracks within the muon system are built. This is the basis of the Level-2 of the muon trigger. The last step is the propagation of these tracks to the silicon tracker. In that stage the information of the muon spectrometer and of the tracker system are combined, giving the final muon track used by the third level of the muon trigger.

The inner portion of the CMS microstrip Tracker consists of 3540 silicon detector modules; its construction has been under full responsibility of seven INFN (Istituto Nazionale di Fisica Nucleare) and University laboratories in Italy. In this note procedures and strategies, which were developed and perfected to qualify the Tracker Inner Barrel and Inner Disks modules for installation, are described. In particular the tests required to select highly reliable detector modules are illustrated and a summary of the results from the full Inner Tracker module test is presented. 1) INFN sez. di Catania and Universita di Catania, Italy 2) INFN sez. di Perugia and Universita di Perugia, Italy 3) INFN sez. di Pisa and Scuola Normale Superiore di Pisa, Italy 4) INFN sez. di Pisa and Universita di Pisa, Italy 5) INFN sez. di Pisa, Italy 6) INFN sez. di Torino and Universita di Torino, Italy 7) INFN sez. di Torino, Italy 8) INFN sez. di Firenze, Italy 9) INFN sez. di Bari and Dipartimento Interateneo di Fisica di Bari, Italy 10) INFN sez. di Bari, Italy 11) INFN sez. di Padova, Italy 12) INFN sez. di Firenze and Universita di Firenze, Italy 13) INFN sez. di Padova and Universita di Padova, Italy 14) INFN sez. di Perugia, Italy a) On leave from ISS, Bucharest, Romania b) On leave from IFIN-HH, Bucharest, Romania c) Corresponding Author

This document summarises the talks and discussions happened during the VBSCan Split17 workshop, the first general meeting of the VBSCan COST Action network. This collaboration is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

Precision measurements of multiboson production are a validation of the Standard Model.These multiboson processes are a background to Higgs boson measurements and searches for Beyond the Standard Model physics.In this contribution, we presented recent measurements of multiboson final states performed in CMS, involving W, Z and photon combinations.Inclusive and differential cross sections were compared to different theoretical predictions.Phase space regions that provide sensitivity to anomalous triple or quartic gauge couplings were also shown.These coupling strengths are directly related to the broken electroweak symmetry and deviations from the SM are a clear signal of new physics.

The production of massive vector boson pairs is a key process for the understanding of the non-abelian gauge structure of the standard model and for the comprehension of the electroweak symmetry breaking mechanism. The study of the production of vector boson pairs with the presence of two jets in the event allows measuring the electroweak production of vector bosons in association with jets, in particular made up through vector boson scattering processes. In this contribution, we presented the recent results from the study of the production of dibosons in association with two jets at $\sqrt{s}$ = 13 TeV.

This document reports the first year of activity of the VBSCan COST Action network, as summarised by the talks and discussions happened during the VBSCan Thessaloniki 2018 workshop. The VBSCan COST action is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

This document reports the first year of activity of the VBSCan COST Action network, as summarised by the talks and discussions happened during the VBSCan Thessaloniki 2018 workshop. The VBSCan COST action is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

This document reports the first year of activity of the VBSCan COST Action network, as summarised by the talks and discussions happened during the VBSCan Thessaloniki 2018 workshop. The VBSCan COST action is aiming at a consistent and coordinated study of vector-boson scattering from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

There are many possibilities for new physics beyond the Standard Model that feature non-standard Higgs sectors. These may introduce new sources of CP violation, and there may be mixing between multiple Higgs bosons or other new scalar bosons. Alternatively, the Higgs may be a composite state, or there may even be no Higgs at all. These non-standard Higgs scenarios have important implications for collider physics as well as for cosmology, and understanding their phenomenology is essential for a full comprehension of electroweak symmetry breaking. This report discusses the most relevant theories which go beyond the Standard Model and its minimal, CP-conserving supersymmetric extension: two-Higgs-doublet models and minimal supersymmetric models with CP violation, supersymmetric models with an extra singlet, models with extra gauge groups or Higgs triplets, Little Higgs models, models in extra dimensions, and models with technicolour or other new strong dynamics. For each of these scenarios, this report presents an introduction to the phenomenology, followed by contributions on more detailed theoretical aspects and studies of possible experimental signatures at the LHC and other colliders.