P. Avery

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Using the CLEO II detector, we have measured the differential cross sections for exclusive two-photon production of light pseudoscalar mesons ${\ensuremath{\pi}}^{0},$ \ensuremath{\eta}, and ${\ensuremath{\eta}}^{\ensuremath{'}}.$ From our measurements we have obtained the form factors associated with the electromagnetic transitions ${\ensuremath{\gamma}}^{*}\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\gamma}}\mathrm{meson}.$ We have measured these form factors in the momentum transfer ranges from 1.5 to 9, 20, and $30{\mathrm{GeV}}^{2}$ for ${\ensuremath{\pi}}^{0},$ \ensuremath{\eta}, and ${\ensuremath{\eta}}^{\ensuremath{'}},$ respectively, and have made comparisons to various theoretical predictions.

Using data collected with the CLEO detector operating at the CESR e+e- collider at sqrt[s]=3.97-4.26 GeV, we investigate 15 charmonium decay modes of the psi(4040), psi(4160), and Y(4260) resonances. We confirm, at 11 sigma significance, the BABAR Y(4260)-->pi+pi- J/psi discovery, make the first observation of Y(4260)--> pi(0)pi(0) J/psi (5.1 sigma), and find the first evidence for Y(4260)-->K+K- J/psi(3.7 sigma). We measure e+e- cross sections at sqrt[s]=4.26 GeV as sigma(pi+pi- J/psi)=58(+12)(-10)+/-4 pb, sigma(pi(0)pi(0) J/psi)=23(+12)(-8)+/-1 pb, and sigma(K+K- J/psi)=9(+9)(-5)+/-1 pb, in which the uncertainties are statistical and systematic, respectively. Upper limits are placed on other decay rates from all three resonances.

We report the first evidence of charmless semileptonic decays of B mesons. In the momentum interval 2.4–2.6 GeV/c where the background from b→clν is negligible, the average of the measured b→ueν and b→uμν partial branching ratios is ΔBub(2.4,2.6) =(1.8±0.4±0.3)×10−4. Inclusion of data from the interval 2.2–2.4 GeV/c, where the lepton yield is dominated by b→clν, gives ΔBub(2.2,2.6) =(3.3±0.8±0.8)×10−4. ‖Vub/Vcb‖ depends on the theoretical model of b→ulν decay and is approximately 0.1.Received 8 November 1989DOI:https://doi.org/10.1103/PhysRevLett.64.16©1990 American Physical Society

Abstract Immunophenotypes in lymphoproliferative diseases (LPD) are prognostically significant, yet causative factors for these conditions, and specifically those associated with heritable risk, remain elusive. The full spectrum of LPD seen in humans occurs in dogs, but the incidence and lifetime risk of naturally occurring LPD differs among dog breeds. Taking advantage of the limited genetic heterogeneity that exists within dog breeds, we tested the hypothesis that the prevalence of LPD immunophenotypes would differ among different breeds. The sample population included 1,263 dogs representing 87 breeds. Immunophenotype was determined by the presence of clonal rearrangements of immunoglobulin heavy chain or T-cell receptor γ chain. The probability of observing the number of B-cell or T-cell tumors in a particular breed or breed group was compared with three reference populations. Significance was computed using χ2 test, and logistic regression was used to confirm binomial predictions. The data show that, among 87 breeds tested, 15 showed significant differences from the prevalence of LPD immunophenotypes seen across the dog population as a whole. More significantly, elevated risk for T-cell LPD seems to have arisen ancestrally and is retained in related breed groups, whereas increased risk for B-cell disease may stem from different risk factors, or combinations of risk factors, arising during the process of breed derivation and selection. The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD.

Background Canine T‐cell lymphoma ( TCL ) is clinically and histologically heterogeneous with some forms, such as T‐zone lymphoma ( TZL ), having an indolent course. Immunophenotyping is an important tool in the classification of TCL in people, and can be equally useful in dogs. Hypothesis/Objectives We hypothesized that loss of expression of the CD 45 antigen is a specific diagnostic feature of TZL . Animals Twenty dogs with concurrent histology and immunophenotyping by flow cytometry were studied in depth. An additional 494 dogs diagnosed by immunophenotyping were used to characterize the population of dogs with this disease. Methods Lymph node biopsies from 35 dogs with TCL were classified by 2 pathologists using WHO criteria. Twenty lymph nodes were from dogs with CD 45− TCL and 15 were from CD 45+ TCL . The pathologists were blinded to the flow cytometry findings. Outcome information was sought for the 20 dogs with CD 45− lymphoma, and population characteristics of the additional 494 dogs were described. Results All 20 CD 45− cases were classified as TZL . The 15 CD 45+ cases were classified as aggressive TCL and are described in an accompanying paper. TZL cases had a median survival of 637 days. Examination of 494 additional dogs diagnosed with TZL by immunophenotyping demonstrated that 40% of cases are in Golden Retrievers, are diagnosed at a median age of 10 years, and the majority have lymphadenopathy and lymphocytosis. Conclusions TZL has unique immunophenotypic features that can be used for diagnosis.

We have studied exclusive, radiative B meson decays to charmless mesons in 9.7x10(6) B&Bmacr; decays accumulated with the CLEO detector. We measure B(B0-->K(*0)(892)gamma) = (4.55(+0.72)(-0. 68)+/-0.34)x10(-5) and B(B+-->K(*+)(892)gamma) = (3.76(+0.89)(-0. 83)+/-0.28)x10(-5). We have searched for CP asymmetry in B-->K(*)(892)gamma decays and measure A(CP) = +0.08+/-0.13+/-0.03. We report the first observation of B-->K(*)(2)(1430)gamma decays with a branching fraction of (1.66(+0.59)(-0.53)+/-0.13)x10(-5). No evidence for the decays B-->rhogamma and B0-->omegagamma is found and we limit B(B-->(rho/omega)gamma)/B(B-->K(*)(892)gamma)<0.32 at 90% C.L.

We have measured ${B}^{0}$B${\ifmmode\bar\else\textasciimacron\fi{}}^{0}$ mixing by observing like-sign dilepton events in \ensuremath{\Upsilon}(4S) decay. Assuming that the semileptonic branching fractions of the charged and neutral B mesons are equal and that the \ensuremath{\Upsilon}(4S) decays to ${B}^{+}$${B}^{\mathrm{\ensuremath{-}}}$ 55% of the time and to ${B}^{0}$B${\ifmmode\bar\else\textasciimacron\fi{}}^{0}$ 45% of the time, we measure the mixing parameter r to be 0.19\ifmmode\pm\else\textpm\fi{}0.06\ifmmode\pm\else\textpm\fi{}0.06, where the first error is statistical and the second is systematic.

We use data collected with the CLEO II detector to perform a high-statistics measurement of the resonant substructure in ${D}^{0}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{0}$ decays. We find that the Dalitz plot is well represented by a combination of seven quasi-two-body decay channels $[{K}^{*0}{\ensuremath{\pi}}^{0},{K}^{\ensuremath{-}}\ensuremath{\rho},{K}^{*\ensuremath{-}}{\ensuremath{\pi}}^{+},{K}_{0}{(1430)}^{\ensuremath{-}}{\ensuremath{\pi}}^{+},{K}_{0}{(1430)}^{0}{\ensuremath{\pi}}^{0},{K}^{\ensuremath{-}}{\ensuremath{\rho}}^{+}(1700),$ and ${K}^{*}{(1680)}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}],$ plus a small non-resonant component. We see no evidence of a scalar $\stackrel{\ensuremath{\rightarrow}}{\ensuremath{\kappa}}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ resonance in the mass range recently reported by other groups. Using the amplitudes and phases from this analysis, we calculate an integrated $\mathrm{CP}$ asymmetry of $\ensuremath{-}0.031\ifmmode\pm\else\textpm\fi{}0.086.$

We extract a relatively precise value for the decay constant of the ${D}^{+}$ meson by measuring $\mathcal{B}({D}^{+}\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}\ensuremath{\nu})=(4.40\ifmmode\pm\else\textpm\fi{}{0.66}_{\ensuremath{-}0.12}^{+0.09})\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$ using $281\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$ of data taken on the $\ensuremath{\psi}(3770)$ resonance with the CLEO-$c$ detector. We find ${f}_{{D}^{+}}=(222.6\ifmmode\pm\else\textpm\fi{}{16.7}_{\ensuremath{-}3.4}^{+2.8})\text{ }\text{ }\mathrm{MeV}$, and compare with current theoretical calculations. We also set a 90% confidence upper limit on $\mathcal{B}({D}^{+}\ensuremath{\rightarrow}{e}^{+}\ensuremath{\nu})&lt;2.4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ which constrains new physics models.

We have used the momentum spectrum of leptons produced in semileptonic $B$-meson decays to set a 90%-confidence-level upper limit on $\frac{\ensuremath{\Gamma}(b\ensuremath{\rightarrow}\mathrm{ul}\ensuremath{\nu})}{\ensuremath{\Gamma}(b\ensuremath{\rightarrow}\mathrm{cl}\ensuremath{\nu})}$ of 4%. We also measure the semileptonic branching fractions of the $B$ meson to be (12.0\ifmmode\pm\else\textpm\fi{}0.7\ifmmode\pm\else\textpm\fi{}0.5)% for electrons and (10.8\ifmmode\pm\else\textpm\fi{}0.6\ifmmode\pm\else\textpm\fi{}1.0)% for muons.

CLEO has studied B decays to πℓν, ρℓν, and ωℓν, where ℓ=eorμ, by incorporating the missing momentum into full B reconstruction. With the B0 and B+ modes combined according to isospin predictions for the relative partial widths, we obtain B(B0→π−ℓ+ν)=(1.8±0.4±0.3±0.2)×10−4 and B(B0→ρ−ℓ+ν)=(2.5±0.4+0.5−0.7±0.5)×10−4, where the errors are statistical, systematic, and the estimated model dependence. We also estimate |Vub|=(3.3±0.2+0.3−0.4±0.7)×10−3.Received 1 July 1996DOI:https://doi.org/10.1103/PhysRevLett.77.5000©1996 American Physical Society

The construction and performance of a large aperture magnetic detector designed for use at the Cornell Electon Storage Ring is descr bed.

Measurements of the ${e}^{+}{e}^{\ensuremath{-}}$ cross section above $B\overline{B}$ threshold are reported. Structures are observed which could be the $\ensuremath{\Upsilon}(5S)$ and $\ensuremath{\Upsilon}(6S)$ resonances. The masses and widths are given and compared with various potential-model predictions. Average charged multiplicities and inclusive lepton yields are also presented.

$B$-meson decays to final states consisting of a ${D}^{0}$ or ${D}^{*\ifmmode\pm\else\textpm\fi{}}$ and one or two charged pions have been observed. The charged-$B$ mass is 5270.8 \ifmmode\pm\else\textpm\fi{} 2.3 \ifmmode\pm\else\textpm\fi{} 2.0 MeV and the neutral-$B$ mass is 5274.2 \ifmmode\pm\else\textpm\fi{} 1.9 \ifmmode\pm\else\textpm\fi{} 2.0 MeV.

Class II major histocompatibility complex (MHC) is an independent predictor of outcome in human B-cell lymphoma. We assessed class II expression together with other markers for their impact on prognosis in canine B-cell lymphoma.Low class II MHC expression, large cell size, and expression of CD34 will predict a poorer outcome in canine B-cell lymphoma. Expression of CD5 and CD21 on tumor cells also may be associated with outcome.One hundred and sixty dogs with cytologically confirmed lymphoma.Patient signalment, treatment type, and flow cytometry characteristics were analyzed for their influence on outcome. A multivariable predictive model of survival was generated using 2/3 of the patients and validated on the remaining 1/3 of the dataset.Class II MHC expression had a negative association with mortality and relapse. Treatment type also influenced relapse and mortality, whereas cell size and patient age was only associated with mortality. CD34, CD21, and CD5 expression was not associated with disease outcome. The constructed model performed variably in predicting the validation group's outcome at the 6-month time point.Low levels of class II MHC expression on B-cell lymphoma predict a poor outcome, as in human B-cell lymphoma. This finding has implications for the use of dogs to model human lymphomas. Class II expression, cell size, treatment, and age can be combined to predict mortality with a high level of specificity.

Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades transcripts containing nonsense mutations, preventing the translation of truncated proteins. NMD also regulates the levels of many endogenous mRNAs. While the mechanism of NMD is gradually understood, its physiological role remains largely unknown. The core NMD genes upf1 and upf2 are essential in several organisms, which may reflect an important developmental role for NMD. Alternatively, the lethality of these mutants might arise from their function in NMD-independent processes. To analyze the developmental importance of NMD, we studied Drosophila mutants of the other core NMD gene, upf3. We compare the resulting upf3 phenotype with those defects observed in upf1 and upf2 loss-of-function mutants, as well as with flies expressing a mutant Upf2 protein unable to bind Upf3. Our results show that Upf3 is an NMD effector in the fly but, unlike Upf1 and Upf2, plays a peripheral role in the degradation of most NMD targets and is not required for development or viability. Furthermore, Upf1 and Upf2 loss-of-function inhibits cell growth and induces apoptosis through a Upf3-independent pathway. Accordingly, disruption of Upf2-Upf1 interaction causes death, while the Upf2-Upf3 complex is dispensable for viability. Our findings suggest that NMD is essential for cell growth and animal development, and that the lethality of upf1 and upf2 mutants is not due to disrupting their roles during NMD-independent processes, but to their function in the degradation of specific mRNAs by the NMD pathway. Furthermore, our results show that Upf3 is not always essential in NMD.

Background Canine T‐cell lymphoma ( TCL ) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD 4 TCL is reported to be the most common subtype of TCL . We assessed flow cytometric characteristics, histologic features when available, and clinical outcomes of CD 4+ TCL to determine if flow cytometry can be used to subclassify this group of lymphomas. Objective To test the hypothesis that canine CD4+ T‐cell lymphoma ( TCL ) is a homogeneous group of lymphomas with an aggressive clinical course. Animals Sixty‐seven dogs diagnosed with CD 4+ TCL by flow cytometry and treated at 1 of 3 oncology referral clinics. Methods Retrospective multivariable analysis of outcome in canine CD 4+ TCL including patient characteristics, treatment, and flow cytometric features. Results The majority of CD 4+ TCL were CD 45+, expressed low class II MHC , and exhibited an aggressive clinical course independent of treatment regimen (median survival, 159 days). Histologically, CD 4+ TCL were classified as lymphoblastic or peripheral T cell. Size of the neoplastic lymphocytes had a modest effect on both PFI and survival in this group. A small number of CD 4+ TCL were CD 45− and class II MHC high, and exhibited an apparently more indolent clinical course (median survival not yet reached). Conclusions and Clinical Importance Although the majority of CD 4+ TCL in dogs had uniform clinical and flow cytometric features and an aggressive clinical course, a subset had a unique immunophenotype that predicts significantly longer survival. This finding strengthens the utility of flow cytometry to aid in the stratification of canine lymphoma.

In e(+)e(-) collisions using the CLEO detector, we have studied the decay of the D0 to the final state K(0)(S)pi(+)pi(-) with the initial flavor of the D0 tagged by the decay D(*+)-->D0pi(+). We use the Dalitz technique to measure the resonant substructure in this final state and clearly observe ten different contributions by fitting for their amplitudes and relative phases. We observe a K(*)(892)(+)pi(-) component which arises from doubly Cabibbo suppressed decays or D0-D0; mixing.

Based on a sample corresponding to 4.3 million produced tau-pair events, we have studied hadronic dynamics in the decay tau- --> nu_tau pi- pi0 pi0 in data recorded by the CLEO II detector operating at the CESR e+e- collider. The decay is dominated by the process tau --> nu_tau a_1(1260), with the a_1 meson decaying to three pions predominantly via the lowest dimensional (mainly S-wave) a_1 --> rho pi Born amplitude. From fits to the Dalitz plot and angular observables, we find significant additional contributions from amplitudes for a_1 decay to sigma pi, f_0(1370) pi and f_2(1270) pi, as well as higher dimensional a_1 --> rho pi and rho' pi amplitudes. The squared sigma pi amplitude accounts for ~15% of the total tau- --> nu_tau pi- pi0 pi0 rate in the models considered. We have searched for additional contributions from tau --> nu_tau pi'(1300). We place 90% confidence level upper limits on the branching fraction for this channel of between 1.0*10^{-4} and 1.9*10^{-4}, depending on the pi' decay mode. The pi- pi0 pi0 mass spectrum is parametrized by a Breit-Wigner form with a mass-dependent width which is specified according to the results of the Dalitz plot fits plus a coupling to an a_1 --> K* K amplitude. From a chi^2 fit, we extract the pole mass and width of the a_1, as well as the magnitude of the K* K coupling. We have also investigated the impact of a possible contribution from the a_1'(1700) meson on this spectrum. Finally, exploiting the parity-violating angular asymmetry in a_1 --> 3pi decay, we determine the signed value of the tau neutrino helicity to be h_{\nu_\tau} = -1.02 +- 0.13(stat.) +- 0.03(syst.+model), confirming the left-handedness of the tau neutrino.

Using 13.7 fb^{-1} of data recorded by the CLEO detector at CESR, we investigate the spectrum of charmed baryons which decay into Lambda_c^+ pi^- pi^+ and are more massive than the Lambda_{c1} baryons. We find evidence for two new states: one is broad and has an invariant mass roughly 480 MeV above that of the Lambda_c^+; the other is narrow with an invariant mass of 596 +- 1 +- 2 MeV above the Lambda_c^+ mass. These results are preliminary.

We have searched for two-body charmless hadronic decays of $B$ mesons. Final states include $ππ$, $K π$, and $KK$ with both charged and neutral kaons and pions; $πρ$, $K ρ$, and $K^*π$; and $Kϕ$, $ K^*ϕ$, and $ϕϕ$. The data used in this analysis consist of 2.6~million $B\bar{B}$~pairs produced at the $Υ(4S)$ taken with the CLEO-II detector at the Cornell Electron Storage Ring (CESR). We measure the branching fraction of the sum of $B^0 \rightarrow π^+π^-$ and $B^0 \rightarrow K^+π^-$ to be $(1.8^{+0.6+0.2}_{-0.5-0.3}\pm0.2) \times 10^{-5}$. In addition, we place upper limits on individual branching fractions in the range from $10^{-4}$ to $10^{-6}$.

We study the exclusive semileptonic B meson decays ${\mathit{B}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}0}$${\mathit{l}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{} and B${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{0}$\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}+}$${\mathit{l}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{} using data collected with the CLEO II detector at the Cornell Electron-positron Storage Ring (CESR). We present measurements of the branching fractions scrB(B${\mathrm{\ifmmode\bar\else\textasciimacron\fi{}}}^{0}$\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}+}$${\mathit{l}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{})= (0.5/${\mathit{f}}_{00}$)[4.49\ifmmode\pm\else\textpm\fi{}0.32(stat.)\ifmmode\pm\else\textpm\fi{}0.39 (syst.)]% and scrB(${\mathit{B}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}0}$${\mathit{l}}^{\mathrm{\ensuremath{-}}}$(\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{})= (0.5/${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$)[5.13\ifmmode\pm\else\textpm\fi{}0.54 (stat) \ifmmode\pm\else\textpm\fi{}0.64 (syst)]%, where ${\mathit{f}}_{00}$ and ${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$ are the neutral and charged B meson production fractions at the \ensuremath{\Upsilon}(4S) resonance, respectively. Assuming isospin invariance and taking the ratio of charged to neutral B meson lifetimes measured at higher energy machines, we determine the ratio ${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$/${\mathit{f}}_{00}$=1.04\ifmmode\pm\else\textpm\fi{}0.13 (stat) \ifmmode\pm\else\textpm\fi{}0.12 (syst) \ifmmode\pm\else\textpm\fi{}0.10 (lifetime); further assuming ${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$+${\mathit{f}}_{00}$=1 we also determine the partial width \ensuremath{\Gamma}(B\ifmmode\bar\else\textasciimacron\fi{}\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}}$l\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{})=[29.9\ifmmode\pm\else\textpm\fi{}1.9 (stat) \ifmmode\pm\else\textpm\fi{}2.7 (syst.) \ifmmode\pm\else\textpm\fi{}2.0 (lifetime)] ${\mathrm{ns}}^{\mathrm{\ensuremath{-}}1}$ (independent of ${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$/${\mathit{f}}_{00}$).From this partial width we calculate B\ifmmode\bar\else\textasciimacron\fi{}\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}}$l\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{} branching fractions that do not depend on ${\mathit{f}}_{+\mathrm{\ensuremath{-}}}$/${\mathit{f}}_{00}$ or the individual B lifetimes, but only on the charged to neutral B lifetime ratio. The product of the CKM matrix element \ensuremath{\Vert}${\mathit{V}}_{\mathit{c}\mathit{b}}$\ensuremath{\Vert} times the normalization of the decay form factor at the point of no recoil of the ${\mathit{D}}^{\mathrm{*}}$ meson, scrF(y=1), is determined from a linear fit to the combined differential decay rate of the exclusive B\ifmmode\bar\else\textasciimacron\fi{}\ensuremath{\rightarrow}${\mathit{D}}^{\mathrm{*}}$l\ensuremath{\nu}\ifmmode\bar\else\textasciimacron\fi{} decays: \ensuremath{\Vert}${\mathit{V}}_{\mathit{c}\mathit{b}}$\ensuremath{\Vert}scrF(1)=0.0351\ifmmode\pm\else\textpm\fi{}0.0019 (stat) \ifmmode\pm\else\textpm\fi{}0.0018 (syst) \ifmmode\pm\else\textpm\fi{}0.0008 (lifetime). The value for \ensuremath{\Vert}${\mathit{V}}_{\mathit{c}\mathit{b}}$\ensuremath{\Vert} is extracted using theoretical calculations of the form factor normalization.

We have studied the "wrong-sign" process D0-->K+pi(-) to search for D0-&Dmacr;( 0) mixing. The data come from 9.0 fb(-1) of e(+)e(-) collisions at sqrt[s] approximately 10 GeV recorded with the CLEO II. V detector. We measure the relative rate of the wrong-sign process D0-->K+pi(-) to the Cabibbo-favored process &Dmacr;( 0)-->K+pi(-) to be R = (0.332(+0.063)(-0.065)+/-0.040)%. We study D0-->K+pi(-) as a function of decay time to distinguish direct doubly Cabibbo-suppressed decay from D0-&Dmacr;( 0) mixing. The amplitudes that describe D0-&Dmacr;( 0) mixing, x(') and y('), are consistent with zero. At the 95% C.L. and without assumptions concerning charge-parity ( CP) violating parameters, we find (1/2)x('2)<0.041% and -5.8%<y(')<1.0%.

The h(c)((1)P(1)) state of charmonium has been observed in the reaction psi(2S) --> pi(0)h(c) --> (gammagamma)(gammaeta(c)) using 3.08 x10(6) psi(2S) decays recorded in the CLEO detector. Data have been analyzed both for the inclusive reaction, where the decay products of the eta(c) are not identified, and for exclusive reactions, in which eta(c) decays are reconstructed in seven hadronic decay channels. We find M(h(c)) = 3524.4 +/- 0.6 +/- 0.4 MeV which corresponds to a hyperfine splitting DeltaM(hf)(1P) triple-bond <M((3)P(J)) - M((1)P(1)) = +1.0 +/- 0.6 +/- 0.4 MeV, and B(psi(2S) --> pi(0)h(c)) x B(h(c) --> gammaeta(c)) = (4.0 +/- 0.8 +/- 0.7) x 10(-4).

Using the CLEO II detector and a sample of 955 000 Υ(4S) decays we have confirmed charmless semileptonic decays of B mesons. In the momentum interval 2.3–2.6 GeV/c we observe an excess of 107±15±11 leptons, which we attribute to b→ulν. This result yields a model-dependent range of values for ‖Vub/Vcb‖ that is lower than has been obtained in previous studies. For the inclusive spectator model of Altarelli et al. we find ‖Vub/Vcb‖=0.076±0.008. Models that describe b→ulν with a limited set of exclusive final states give ‖Vub/Vcb‖=0.06-0.10.Received 7 September 1993DOI:https://doi.org/10.1103/PhysRevLett.71.4111©1993 American Physical Society

We report on the observation of the ηc′(2S01), the radial excitation of the ηc(1S01) ground state of charmonium, in the two-photon fusion reaction γγ→ηc′→KS0K±π∓ in 13.6 fb−1 of CLEO II/II.V data and 13.1 fb−1 of CLEO III data. We obtain M(ηc′)=3642.9±3.1(stat)±1.5(syst) MeV and M(ηc)=2981.8±1.3(stat)±1.5(syst) MeV. The corresponding values of hyperfine splittings between S01 and S13 states are ΔMhf(1S)=115.1±2.0 MeV and ΔMhf(2S)=43.1±3.4 MeV. Assuming that the ηc and ηc′ have equal branching fractions to KSKπ, we obtain Γγγ(ηc′)=1.3±0.6 keV.Received 23 December 2003DOI:https://doi.org/10.1103/PhysRevLett.92.142001©2004 American Physical Society

We present final measurements of 13 charmless hadronic B decay modes from the CLEO experiment. The decay modes include the ten ππ, Kπ, and KK final states and new limits on dibaryonic final states, p¯p, p¯Λ, and Λ¯Λ, as well as a new determination of the ratio B(→BDK)/B(→BDπ). The results are based on the full CLEO II and CLEO III data samples totalling 15.3fb−1 at the Υ(4S), and supercede previously published results.Received 13 February 2003Corrected 6 June 2007DOI:https://doi.org/10.1103/PhysRevD.68.052002©2003 American Physical Society

Using $55.8\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$ of ${e}^{+}{e}^{\ensuremath{-}}$ collisions recorded at the $\ensuremath{\psi}(3770)$ resonance with the CLEO-c detector at CESR, we determine absolute hadronic branching fractions of charged and neutral $D$ mesons using a double tag technique. Among measurements for three ${D}^{0}$ and six ${D}^{+}$ modes, we obtain reference branching fractions $\mathcal{B}({D}^{0}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+})=(3.91\ifmmode\pm\else\textpm\fi{}0.08\ifmmode\pm\else\textpm\fi{}0.09)%$ and $\mathcal{B}({D}^{+}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{+})=(9.5\ifmmode\pm\else\textpm\fi{}0.2\ifmmode\pm\else\textpm\fi{}0.3)%$, where the uncertainties are statistical and systematic, respectively. Final state radiation is included in these branching fractions by allowing for additional, unobserved, photons in the final state. Using a determination of the integrated luminosity, we also extract the cross sections $\ensuremath{\sigma}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{D}^{0}{\overline{D}}^{0})=(3.60\ifmmode\pm\else\textpm\fi{}{0.07}_{\ensuremath{-}0.05}^{+0.07})\text{ }\text{ }\mathrm{nb}$ and $\ensuremath{\sigma}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{D}^{+}{D}^{\ensuremath{-}})=(2.79\ifmmode\pm\else\textpm\fi{}{0.07}_{\ensuremath{-}0.04}^{+0.10})\text{ }\text{ }\mathrm{nb}$.

Canine lymphoproliferative disease often presents with lymphocytosis and is immunophenotypically diverse.Immunophenotype predicts prognosis in canine lymphoproliferative disorders involving circulating lymphocytosis.Dogs that had peripheral blood evaluation performed by flow cytometry by the Clinical Immunology Service at Colorado State University between 2003 and 2005.Outcome data regarding treatment and survival were sought on patients with lymphocytosis comprising a single lymphocyte subset. Ninety-six patients that met the inclusion criteria had sufficient follow-up information to be included in the study.Four main phenotypic classifications were found: CD8+ T-cell, CD21+ B-cell, CD4-8-5+ (aberrant T-cell phenotype), and CD34+ (undifferentiated progenitor). Expression of CD34 predicted poor outcome with median survival of 16 days (P < .0001) compared with other phenotypes. Within the CD8+ phenotype, dogs presenting with a lymphocytosis >30,000 lymphocytes/muL had significantly shorter median survival (131 days) than those presenting with <30,000 lymphocytes/muL (1098 days, P < .0008). Within the T-cell leukemias, there was no difference in outcome between dogs with CD4-8-5+ leukemia and dogs with the CD8+ T-cell phenotype nor was the loss of expression of the pan-leukocyte marker CD45 associated with decreased survival time. A CD21+ lymphocytosis composed of large cells was associated with shorter survival time (129 days) than those with smaller circulating cells (median survival not reached, P < .01).Immunophenotyping provides an objective method for determining prognosis in lymphoproliferative disorders characterized by lymphocytosis.

Evidence is presented for a narrow meson resonance of mass 1970\ifmmode\pm\else\textpm\fi{}5\ifmmode\pm\else\textpm\fi{}5 MeV produced in continuum ${e}^{+}{e}^{\ensuremath{-}}$ annihilations at $\sqrt{s}$ of 10.5 GeV, and decaying into a $\ensuremath{\phi}$ and a charged $\ensuremath{\pi}$.

We report results on the differential and total cross sections for inclusive production of the charmed particles ${D}^{\mathrm{*}+}$, ${D}^{\mathrm{*}0}$, ${D}^{0}$, ${D}^{+}$, ${D}_{s}$, and ${\mathrm{\ensuremath{\Lambda}}}_{\mathit{c}}$ in ${\mathit{e}}^{+}$${\mathit{e}}^{\mathrm{\ensuremath{-}}}$ annihilations at \ensuremath{\surd}s=10.55 GeV. Widely used quark fragmentation models are discussed and compared with the measured charmed-particle momentum distributions. This comparison, as well as that with measurements at other center-of-mass energies, shows the need to take QCD corrections into account and their importance for a correct interpretation of the model parameters. The observed rate of ${D}^{0}$ and ${D}^{+}$ production is compared to the expected total charm production cross section. We measure the probability of a charmed meson being produced as a vector meson and the ${D}^{\mathrm{*}+}$ decay branching fraction into ${D}^{0}$${\ensuremath{\pi}}^{+}$.

We report measurements of single-particle inclusive spectra and two-particle correlations in decays of the \ensuremath{\Upsilon}(1S) resonance and in nonresonant annihilations of electrons and positrons at center-of-mass energy 10.49 GeV, just below BB\ifmmode\bar\else\textasciimacron\fi{} threshold. These data were obtained using the CLEO detector at the Cornell Electron Storage Ring (CESR) and provide information on the production of \ensuremath{\pi}, K, \ensuremath{\rho}, ${K}^{\mathrm{*}}$, \ensuremath{\varphi}, p, \ensuremath{\Lambda}, and \ensuremath{\Xi} in quark and gluon jets. The average multiplicity of hadrons per event for upsilon decays (compared with continuum annihilations) is 11.4 (10.5) pions, 2.4 (2.2) kaons, 0.6 (0.5) ${\ensuremath{\rho}}^{0}$, 1.2 (0.8) ${K}^{\mathrm{*}}$, 0.6 (0.4) protons and antiprotons, 0.15 (0.08) \ensuremath{\varphi}, 0.19 (0.07) \ensuremath{\Lambda} and \ensuremath{\Lambda}\ifmmode\bar\else\textasciimacron\fi{}, and 0.016 (0.005) ${\ensuremath{\Xi}}^{\mathrm{\ensuremath{-}}}$ and \ensuremath{\Xi}\ifmmode\bar\else\textasciimacron\fi{} $^{+}$. We have also seen evidence for \ensuremath{\eta} and ${f}^{0}$ production. The most significant differences between upsilon and continuum final states are (1) the inclusive energy spectra fall off more rapidly with increasing particle energy in upsilon decays, (2) the production of heavier particles, especially baryons, is not as strongly suppressed in upsilon decays, and (3) baryon and antibaryon are more likely to be correlated at long range in upsilon decay than in continuum events.

We have used the measured yield of leptons near the end point of the momentum spectrum from semileptonic B decay to obtain an upper limit on \ensuremath{\Gamma}(b\ensuremath{\rightarrow}ul\ensuremath{\nu})/\ensuremath{\Gamma}(b\ensuremath{\rightarrow}cl\ensuremath{\nu}) and a corresponding limit on \ensuremath{\Vert}${V}_{\mathrm{ub}}$\ensuremath{\Vert}/\ensuremath{\Vert}${V}_{\mathrm{cb}}$\ensuremath{\Vert}.

In a sample of $6.6\ifmmode\times\else\texttimes\fi{}{10}^{6}$ produced $B$ mesons we have observed decays $B\ensuremath{\rightarrow}{\ensuremath{\eta}}^{\ensuremath{'}}K$, with branching fractions $B({B}^{+}\ensuremath{\rightarrow}{\ensuremath{\eta}}^{\ensuremath{'}}{K}^{+})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}({6.5}_{\ensuremath{-}1.4}^{+1.5}\ifmmode\pm\else\textpm\fi{}0.9)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$ and $B({B}^{0}\ensuremath{\rightarrow}{\ensuremath{\eta}}^{\ensuremath{'}}{K}^{0})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}({4.7}_{\ensuremath{-}2.0}^{+2.7}\ifmmode\pm\else\textpm\fi{}0.9)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5}$. We have searched with comparable sensitivity for 17 related decays to final states containing an $\ensuremath{\eta}$ or ${\ensuremath{\eta}}^{\ensuremath{'}}$ meson accompanied by a single particle or low-lying resonance. Our upper limits for these constrain theoretical interpretations of the $B\ensuremath{\rightarrow}{\ensuremath{\eta}}^{\ensuremath{'}}K$ signal.

We have used the CLEO II detector and $2.06{\mathrm{fb}}^{\ensuremath{-}1}$ of $\ensuremath{\Upsilon}(4S)$ data to measure the $B$-meson semileptonic branching fraction. The $B\ensuremath{\rightarrow}\mathrm{Xe}\ensuremath{\nu}$ momentum spectrum was obtained over nearly the full momentum range by using charge and kinematic correlations in events with a high-momentum lepton tag and an additional electron. We find $B(B\ensuremath{\rightarrow}\mathrm{Xe}\ensuremath{\nu})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}(10.49\ifmmode\pm\else\textpm\fi{}0.17\ifmmode\pm\else\textpm\fi{}0.43)%$, with overall systematic uncertainties less than those of untagged single-lepton measurements. We use this result to calculate the magnitude of the Cabibbo-Kobayashi-Maskawa matrix element ${V}_{\mathrm{cb}}$ and to set an upper limit on the fraction of $\ensuremath{\Upsilon}(4S)$ decays to final states other than $B\overline{B}$.

We have measured the first and second moments of the hadronic mass-squared distribution in B -> X_c l nu, for P(lepton) > 1.5 GeV/c. We find <M_X^2 - M_D[Bar]^2> = 0.251 +- 0.066 GeV^2, < (M_X^2 -<M_X^2>)^2 > = 0.576 +- 0.170 GeV^4, where M_D[Bar] is the spin-averaged D meson mass. From that first moment and the first moment of the photon energy spectrum in b -> s gamma, we find the HQET parameter lambda_1 (MS[Bar], to order 1/M^3 and beta_0 alpha_s^2) to be -0.24 +- 0.11 GeV^2. Using these first moments and the B semileptonic width, and assuming parton-hadron duality, we obtain |V_cb| = 0.0404 +- 0.0013.

We have measured the B0B¯0 mixing probability, χd, using a sample of 965 000 BB¯ pairs from Υ(4S) decays. Counting dilepton events, we find χd=0.157±0.016±0.018−0.021+0.028. Using tagged B0 events, we find χd=0.149±0.023±0.019±0.010. The first (second) error is statistical (systematic). The third error reflects a ±15% uncertainty in the assumption, made in both cases, that charged and neutral B pairs contribute equally to dilepton events. We also obtain a limit on the CP impurity in the Bd0 system, ‖Re(εB0)‖<0.045 at 90% C.L.Received 29 April 1993DOI:https://doi.org/10.1103/PhysRevLett.71.1680©1993 American Physical Society

We report on determinations of $|{V}_{\mathrm{ub}}|$ resulting from studies of the branching fraction and ${q}^{2}$ distributions in exclusive semileptonic B decays that proceed via the $\stackrel{\ensuremath{\rightarrow}}{b}u$ transition. Our data set consists of the $9.7\ifmmode\times\else\texttimes\fi{}{10}^{6}$ $B\overline{B}$ meson pairs collected at the $\ensuremath{\Upsilon}(4S)$ resonance with the CLEO II detector. We measure $\mathcal{B}{(B}^{0}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\mathcal{l}}^{+}\ensuremath{\nu})=(1.33\ifmmode\pm\else\textpm\fi{}0.18\ifmmode\pm\else\textpm\fi{}0.11\ifmmode\pm\else\textpm\fi{}0.01\ifmmode\pm\else\textpm\fi{}0.07)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$ and $\mathcal{B}{(B}^{0}\ensuremath{\rightarrow}{\ensuremath{\rho}}^{\ensuremath{-}}{\mathcal{l}}^{+}\ensuremath{\nu})=(2.17\ifmmode\pm\else\textpm\fi{}{0.34}_{\ensuremath{-}0.54}^{+0.47}\ifmmode\pm\else\textpm\fi{}0.41\ifmmode\pm\else\textpm\fi{}0.01)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4},$ where the errors are statistical, experimental systematic, systematic due to residual form-factor uncertainties in the signal, and systematic due to residual form-factor uncertainties in the cross-feed modes, respectively. We also find $\mathcal{B}{(B}^{+}\ensuremath{\rightarrow}\ensuremath{\eta}{\mathcal{l}}^{+}\ensuremath{\nu})=(0.84\ifmmode\pm\else\textpm\fi{}0.31\ifmmode\pm\else\textpm\fi{}0.16\ifmmode\pm\else\textpm\fi{}0.09)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4},$ consistent with what is expected from the $\stackrel{\ensuremath{\rightarrow}}{B}\ensuremath{\pi}\mathcal{l}\ensuremath{\nu}$ mode and quark model symmetries. We extract $|{V}_{\mathrm{ub}}|$ using light-cone sum rules for $0&lt;~{q}^{2}&lt;16{\mathrm{GeV}}^{2}$ and lattice QCD for $16{\mathrm{GeV}}^{2}&lt;~{q}^{2}&lt;{q}_{\mathrm{max}}^{2}.$ Combining both intervals yields $|{V}_{\mathrm{ub}}|=(3.24\ifmmode\pm\else\textpm\fi{}0.22\ifmmode\pm\else\textpm\fi{}{0.13}_{\ensuremath{-}0.39}^{+0.55}\ifmmode\pm\else\textpm\fi{}0.09)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}$ for $\ensuremath{\pi}\mathcal{l}\ensuremath{\nu},$ and $|{V}_{\mathrm{ub}}|=(3.00\ifmmode\pm\else\textpm\fi{}{0.21}_{\ensuremath{-}0.35\ensuremath{-}0.38}^{+0.29+0.49}\ifmmode\pm\else\textpm\fi{}0.28)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}$ for $\ensuremath{\rho}\mathcal{l}\ensuremath{\nu},$ where the errors are statistical, experimental systematic, theoretical, and \ensuremath{\rho}l\ensuremath{\nu} form-factor shape, respectively. Our combined value from both decay modes is $|{V}_{\mathrm{ub}}|=(3.17\ifmmode\pm\else\textpm\fi{}{0.17}_{\ensuremath{-}0.17\ensuremath{-}0.39}^{+0.16+0.53}\ifmmode\pm\else\textpm\fi{}0.03)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}.$

We report a new measurement of the CKM parameter V_ub made with a sample of 9.7 million B B-bar events collected with the CLEO II detector. Using Heavy Quark theory, we combine the observed yield of leptons from semileptonic B decay in the end-point momentum interval 2.2-2.6 GeV/c with recent CLEO II data on B --> X_s gamma to find |V_ub| = (4.08 +/- 0.34 +/- 0.44 +/- 0.16 +/- 0.24) x 10^-3, where the first two uncertainties are experimental and the last two are from theory.

We observe signals for the decays ψ(3770)→XJ/ψ from data acquired with the CLEO detector operating at the CESR e+e− collider with √s=3773 MeV. We measure the following branching fractions B(ψ(3770)→XJ/ψ) and significances: (189±20±20)×10−5 (11.6σ) for X=π+π−, (80±25±16)×10−5 (3.4σ) for X=π0π0, and (87±33±22)×10−5 (3.5σ) for X=η, where the errors are statistical and systematic, respectively. The radiative return process e+e−→γψ(2S) populates the same event sample and is used to measure Γee[ψ(2S)]=(2.54±0.03±0.11) keV.Received 9 August 2005DOI:https://doi.org/10.1103/PhysRevLett.96.082004©2006 American Physical Society

We report new measurements of the branching fractions B(B−→D0l−¯ν), B(¯B0→D+l−¯ν), and B(B−→D*0l−¯ν). Combining these results with our previous measurement of B(¯B0→D*+l−¯ν), we find that the ratio of semileptonic widths for final states with a vector meson and pseudoscalar meson is (2.6+1.1+1.0−0.6−0.8) and the ratio of charged- to neutral-B-meson lifetimes is (0.89±0.19±0.13)(f00f+−) where (f00f+−) is the ratio of neutral- to charged-B-meson production at the Υ(4S). From the ¯B→Dl−¯ν branching fraction, we calculate |Vcb|=0.040±0.006±0.006, where the first error is statistical and the second is systematic and dominated by the uncertainty in the B-meson lifetime.Received 1 August 1990DOI:https://doi.org/10.1103/PhysRevD.43.651©1991 American Physical Society

Limits are set on ${B}^{0}$B${\ifmmode\bar\else\textasciimacron\fi{}}^{0}$ mixing by use of dilepton events from \ensuremath{\Upsilon}(4S) decay. On the assumption that the charged- and neutral-B semileptonic branching ratios are equal and that 41% of the B mesons from the \ensuremath{\Upsilon}(4S) are neutral, a 90%-confidence-level upper limit of 24% is set on ${B}^{0}$B${\ifmmode\bar\else\textasciimacron\fi{}}^{0}$ mixing. Limits are also given for the ratio of the lifetimes of neutral and charged B mesons. The 90%-confidence-level limits are 2.05.

Using data obtained with the CLEO III detector, running at the Cornell Electron Storage Ring (CESR), we report on a new study of exclusive radiative $\ensuremath{\Upsilon}(1\mathrm{S})$ decays into the final states $\ensuremath{\gamma}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$, $\ensuremath{\gamma}{K}^{+}{K}^{\ensuremath{-}}$, and $\ensuremath{\gamma}p\overline{p}$. We present branching ratio measurements for the decay modes $\ensuremath{\Upsilon}(1\mathrm{S})\ensuremath{\rightarrow}\ensuremath{\gamma}{f}_{2}(1270)$, $\ensuremath{\Upsilon}(1\mathrm{S})\ensuremath{\rightarrow}\ensuremath{\gamma}{f}_{2}^{\ensuremath{'}}(1525)$, and $\ensuremath{\Upsilon}(1\mathrm{S})\ensuremath{\rightarrow}\ensuremath{\gamma}{K}^{+}{K}^{\ensuremath{-}}$; helicity production ratios for ${f}_{2}(1270)$ and ${f}_{2}^{\ensuremath{'}}(1525)$; upper limits for the decay $\ensuremath{\Upsilon}(1\mathrm{S})\ensuremath{\rightarrow}\ensuremath{\gamma}{f}_{J}(2200)$, with ${f}_{J}(2220)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$, ${K}^{+}{K}^{\ensuremath{-}}$, $p\overline{p}$; and an upper limit for the decay $\ensuremath{\Upsilon}(1\mathrm{S})\ensuremath{\rightarrow}\ensuremath{\gamma}X(1860)$, with $X(1860)\ensuremath{\rightarrow}\ensuremath{\gamma}p\overline{p}$.

This article describes the Open Science Grid, a large distributed computational infrastructure in the United States which supports many different high-throughput scientific applications, and partners (federates) with other infrastructures nationally and internationally to form multi-domain integrated distributed systems for science. The Open Science Grid consortium not only provides services and software to an increasingly diverse set of scientific communities, but also fosters a collaborative team of practitioners and researchers who use, support and advance the state of the art in large-scale distributed computing. The scale of the infrastructure can be expressed by the daily throughput of around seven hundred thousand jobs, just under a million hours of computing, a million file transfers, and half a petabyte of data movement. In this paper we introduce and reflect on some of the OSG capabilities, usage and activities.

The importance of the $H\ensuremath{\rightarrow}ZZ\ensuremath{\rightarrow}4\ensuremath{\ell}$ ``golden'' channel was shown by its major role in the discovery, by the ATLAS and CMS collaborations, of a Higgs-like boson with mass near 125 GeV. We analyze the discrimination power of the matrix element method both for separating the signal from the irreducible $ZZ$ background and for distinguishing various spin and parity hypotheses describing a signal in this channel. We show that the proper treatment of interference effects associated with permutations of identical leptons in the $4e$ and $4\ensuremath{\mu}$ final states plays an important role in achieving the best sensitivity in measuring the properties of the newly discovered boson. We provide a code, mekd, that calculates kinematic discriminants based on the full leading-order matrix elements and which will aid experimentalists and phenomenologists in their continuing studies of the $H\ensuremath{\rightarrow}ZZ\ensuremath{\rightarrow}4\ensuremath{\ell}$ channel.

Abstract A 5‐year‐old male neutered Bernese Mountain Dog was presented for cutaneous plasmacytoma, which was treated by surgical excision. Four months later, the dog developed multiple skin masses, hyphema, pericardial and mild bicavitary effusions, myocardial masses, and marked plasmacytosis in the peripheral blood. Circulating plasma cells expressed CD 34 and MHC class II by flow cytometry. Immunocytochemistry demonstrated that these cells were strongly positive for multiple myeloma oncogene 1/interferon regulatory factor 4 ( MUM ‐1) and weakly to moderately positive for Pax5. The dog was hypoglobulinemic but had a monoclonal IgA gammopathy detected by serum immunofixation electrophoresis. The PCR analysis of antigen receptor gene rearrangements ( PARR ) by fragment analysis using GeneScan methodology revealed that plasmacytoid cells in the original cutaneous plasmacytoma and peripheral blood had an identical immunoglobulin heavy chain gene (IgH) rearrangement, indicating that both populations were derived from the same neoplastic clone. Canine cutaneous plasmacytoma rarely progresses to a malignant form and plasma cell leukemia is rarely diagnosed in the dog. This report describes a case of cutaneous plasmacytoma progressing to plasma cell leukemia with a rapid and aggressive clinical course. This report also highlights the utility of flow cytometry, immunocytochemistry, immunofixation electrophoresis, and PARR by fragment analysis using GeneScan methodology in the diagnosis of this hematopoietic neoplasm.

Abstract Protein electrophoresis and immunotyping can be a useful adjunct to the standard biochemical techniques for characterizing serum and urine proteins. This paper reviews currently available and commonly used methods for diagnostic protein electrophoresis, including both agarose gel and capillary zone electrophoretic techniques and total protein assessments. Immunofixation and immunosubtraction methods for identification of immunoglobulin location and class are also presented. Practical application of quality assurance and quality control strategies in compliance with American Society of Veterinary Clinical Pathology (ASVCP) best practices are discussed. Commonly encountered serum and urine electrophoretic diagnostic patterns, including electrophoretically normal, acute‐phase protein responses, polyclonal gammopathies, restricted polyclonal/oligoclonal gammopathies, paraproteinemias (monoclonal or biclonal gammopathies), and Bence‐Jones proteinurias are also reviewed using relevant case material. Cases in which immunofixation electrophoresis are particularly useful are highlighted, and methodologies to more accurately quantify serum monoclonal proteins (M‐proteins), monitoring tests commonly used in human medicine, are discussed.

We have used the CLEO-II detector at the Cornell Electron Storage Ringe (CESR) to study the inclusive production of charmonium mesons in a sample of 2.15 million BB¯ events. We find inclusive branching fractions of (1.12±0.04±0.06)% for B→J/ψX, (0.34±0.04±0.03)% for B→ψ′X, and (0.40±0.06±0.04)% for B→χc1X. We also find some evidence for the inclusive production of χc2, and set an upper limit for the branching fraction of the inclusive decay B→ηcX of 0.9% at 90% confidence level. Momentum spectra for inclusive J/ψ, ψ′, and χc1 production are presented. These measurements are compared to theoretical calculations.Received 13 December 1994DOI:https://doi.org/10.1103/PhysRevD.52.2661©1995 American Physical Society

We present the first evidence for the production of $\ensuremath{\Upsilon}(1D)$ states in the four-photon cascade, $\ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\chi}}_{b}(2P),$ ${\ensuremath{\chi}}_{b}(2P)\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\Upsilon}(1D),$ $\ensuremath{\Upsilon}(1D)\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\chi}}_{b}(1P),$ ${\ensuremath{\chi}}_{b}(1P)\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\Upsilon}(1S),$ followed by the $\ensuremath{\Upsilon}(1S)$ annihilation into ${e}^{+}{e}^{\ensuremath{-}}$ or ${\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}.$ The signal has a significance of 10.2 standard deviations. The measured product branching ratio for these five decays, $(2.5\ifmmode\pm\else\textpm\fi{}0.5\ifmmode\pm\else\textpm\fi{}0.5)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}5},$ is consistent with the theoretical estimates. The data are dominated by the production of one $\ensuremath{\Upsilon}(1D)$ state consistent with the $J=2$ assignment. Its mass is determined to be $(10161.1\ifmmode\pm\else\textpm\fi{}0.6\ifmmode\pm\else\textpm\fi{}1.6)$ MeV, which is consistent with the predictions from potential models and lattice QCD calculations. We also searched for $\ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}\ensuremath{\gamma}{\ensuremath{\chi}}_{b}(2P),$ ${\ensuremath{\chi}}_{b}(2P)\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\Upsilon}(1D),$ followed by either $\ensuremath{\Upsilon}(1D)\ensuremath{\rightarrow}\ensuremath{\eta}\ensuremath{\Upsilon}(1S)$ or $\ensuremath{\Upsilon}(1D)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\Upsilon}(1S).$ We find no evidence for such decays and set upper limits on the product branching ratios.

We have studied two-body charmless hadronic decays of B mesons into the final states $\pi\pi$, $K \pi$, and $KK$. Using 3.3 million $B\bar{B}$ pairs collected with the CLEO-II detector, we have made the first observation of the decays $B^0\to K^+\pi^-$, $B^+\to K^0\pi^+$, and the sum of $B^+ \to \pi^+\pi^0$ and $B^+ \to K^+\pi^0$ decays (an average over charge-conjugate states is always implied). We place upper limits on branching fractions for the remaining decay modes.

We have studied hadronic decays of B mesons. We report measurements of exclusive branching ratios of several charm decay modes of B mesons to final states with a D or D∗ and one to three charged pions or a charged ρ and to final states with a ψ or ψ′, a kaon, and up to two charged pions. We have also measured inclusive branching ratios for B decays to D and D∗ and the spectra of these particles in B decays. The total charm content in B decay is found to be (101±12)%. The branching ratios and spectra are compared to form-factor models. We extract the parameters a1 and a2 of the model of Bauer, Stech, and Wirbel and the DS decay constant. The masses of the ¯B0 and B− mesons are measured. The mass difference between ¯B0 and B− is found to be -0.4±0.6±0.5 MeV/c2.Received 29 July 1991DOI:https://doi.org/10.1103/PhysRevD.45.21©1992 American Physical Society

Using the CLEO detector at the Cornell Electron-positron Storage Ring, we have measured the scaled momentum spectra, $d\ensuremath{\sigma}/d{x}_{p}$, and the inclusive production cross sections of the charm mesons ${D}^{+}$, ${D}^{0}$, ${D}^{\ensuremath{\star}+}$, and ${D}^{\ensuremath{\star}0}$ in ${e}^{+}{e}^{\ensuremath{-}}$ annihilation at about 10.5 GeV center of mass energy, excluding the decay products of $B$ mesons. The statistical accuracy and momentum resolution are superior to previous measurements at this energy.

We describe a search for psi(3770) decay to two-body non-DDbar final states in e+e- data produced by the CESR collider and analyzed with the CLEO-c detector. Vector-pseudoscalar production of Rho0Pi0, Rho+Pi-, OmegaPi0, PhiPi0, RhoEta, OmegaEta, PhiEta, RhoEtaPrime, OmegaEtaPrime, PhiEtaPrime, Kstar0 K0bar, and Kstar+K- is studied along with that of BOnePi (BOne0Pi0 and BOne+Pi-) and Pi+Pi-Pi0. A statistically significant signal is found for PhiEta, at an excess cross section of (2.4 +- 0.6) pb [Gamma_{PhiEta} (psi(3770)) =(74 +- 16)Mev], and a suggestive suppression of Pi+Pi-Pi0 and RhoPi. We conclude with form factor determinations for OmegaPi0, RhoEta, and RhoEtaPrime.

Using a sample of integrated luminosity 1.68 fb−1 collected with the CLEO-II detector at the Cornell Electron Storage Ring, we measure the branching ratios for the dominant exclusive semileptonic decays D → Klν and D → K∗lν, using charged and neutral D mesons. We also make a precise measurement of the vector form factor for the decay D0 → K−l+ν, using a sample of 2700 events.

Using data recorded by the CLEO-II detector at Cornell Electron Storage Ring (CESR), we report the first observation of a narrow state decaying into Ξ+cπ−. The state has mass difference M(Ξ+cπ−)−M(Ξ+c) of 178.2 ± 0.5 ± 1.0 MeV/c2, and a width of <5.5 MeV/c2 (90% confidence level limit). The most likely explanation of this new state is that it is the Ξ*0c, the JP=32+ spin excitation of the Ξ0c charmed baryon.Received 15 August 1995DOI:https://doi.org/10.1103/PhysRevLett.75.4364©1995 American Physical Society

We have investigated $D^{+}\pi^{-}$ and $D^{*+}\pi^{-}$ final states and observed the two established $L=1$ charmed mesons, the $D_1(2420)^0$ with mass $2421^{+1+2}_{-2-2}$ MeV/c$^{2}$ and width $20^{+6+3}_{-5-3}$ MeV/c$^{2}$ and the $D_2^*(2460)^0$ with mass $2465 \pm 3 \pm 3$ MeV/c$^{2}$ and width $28^{+8+6}_{-7-6}$ MeV/c$^{2}$. Properties of these final states, including their decay angular distributions and spin-parity assignments, have been studied. We identify these two mesons as the $j_{light}=3/2$ doublet predicted by HQET. We also obtain constraints on {\footnotesize $\Gamma_S/(\Gamma_S + \Gamma_D)$} as a function of the cosine of the relative phase of the two amplitudes in the $D_1(2420)^0$ decay.

We report results on inclusive production of the charmed baryon ${{\ensuremath{\Lambda}}_{c}}^{+}$ from ${e}^{+}{e}^{\ensuremath{-}}$ annihilations at $\sqrt{s}=10.5$ GeV. Measurements are presented of the inclusive cross section times branching fraction for the continuum production of ${{\ensuremath{\Lambda}}_{c}}^{+}$ as observed in six different decay modes, and of a new, improved value of the ${{\ensuremath{\Lambda}}_{c}}^{+}$ mass. The inclusive cross section times the branching fraction into $p{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ is measured to be 10.0\ifmmode\pm\else\textpm\fi{}1.5\ifmmode\pm\else\textpm\fi{}1.5 pb summed over all ${x}_{p}$. The branching fractions of ${{\ensuremath{\Lambda}}_{c}}^{+}$ into $p{\overline{K}}^{0}$, $p{\overline{K}}^{0}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$, $\ensuremath{\Lambda}{\ensuremath{\pi}}^{+}$, $\ensuremath{\Lambda}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$, and ${\ensuremath{\Xi}}^{\ensuremath{-}}{K}^{+}{\ensuremath{\pi}}^{+}$ relative to that into $p{K}^{\ensuremath{-}}{\ensuremath{\pi}}^{+}$ are measured to be 0.44\ifmmode\pm\else\textpm\fi{}0.07\ifmmode\pm\else\textpm\fi{}0.05, 0.43\ifmmode\pm\else\textpm\fi{}0.12\ifmmode\pm\else\textpm\fi{}0.04, 0.18\ifmmode\pm\else\textpm\fi{}0.03\ifmmode\pm\else\textpm\fi{}0.03, 0.65\ifmmode\pm\else\textpm\fi{}0.11\ifmmode\pm\else\textpm\fi{}0.12, and 0.15\ifmmode\pm\else\textpm\fi{}0.04\ifmmode\pm\else\textpm\fi{}0.03, respectively. The ${{\ensuremath{\Lambda}}_{c}}^{+}$ mass is measured to be 2284.7\ifmmode\pm\else\textpm\fi{}0.6\ifmmode\pm\else\textpm\fi{}0.7 MeV/${\mathit{c}}^{2}$. The measured momentum distributions for continuum production of ${{\ensuremath{\Lambda}}_{c}}^{+}$ are compared to analytical fragmentation functions and to other measurements.

Using the CLEO detector at the Cornell Electron Storage Ring, we have found evidence for L=1 charmed mesons in e+e− annihilations. We observe a D**0 state at mass 2461±3±1 MeV/c2 and width 20−12−10+9+9 MeV/c2 decaying to D+π−. We also see an enhancement in the m(D*+π−)−m(D*+) mass-difference spectrum and by examining D*+ decay-angle dependence, we see structure consistent with two states decaying to D*+π−. We observe a lower-mass state, at mass (2428±3±2) MeV/c2 and width (23−6−4+8+10) MeV/c2, assuming that the higher-mass component is from the decay D**0(2461)→D*+π−. We present arguments for the spin-parity assignments of these states. We also report observation of candidate L=1 cs¯ state decaying to D*+Ks0.Received 24 August 1989DOI:https://doi.org/10.1103/PhysRevD.41.774©1990 American Physical Society

We have searched for flavor-changing neutral-current weak decays of the $b$ quark and find ${R}_{B}(b\ensuremath{\rightarrow}{l}^{+}{l}^{\ensuremath{-}}X)&lt;0.31%$ at 90% confidence level. This limit excludes models with the $b$ quark in a left-handed isosinglet. We also place limits on the ratio of the ${B}^{\ifmmode\pm\else\textpm\fi{}}$ and ${B}^{0}$ semileptonic branching fractions and on ${B}^{0}{\stackrel{-}{B}}^{0}$ mixing.

We have set upper limits for rare exclusive decays of B mesons arising from higher order processes in the standard model of electroweak interactions. Such decays may occur via “penguin diagrams” in B decay. We also set an upper limit on a lepton-number-violating decay mode of the neutral B meson.

The charged multiplicity has been measured at the $\ensuremath{\Upsilon}(4S)$ and a value of 5.75\ifmmode\pm\else\textpm\fi{}0.1\ifmmode\pm\else\textpm\fi{}0.2 has been obtained for the mean charged multiplicity in $B$-meson decay. Combining this result with the measurement of prompt leptons from $B$ decay, the values 4.1\ifmmode\pm\else\textpm\fi{}0.35\ifmmode\pm\else\textpm\fi{}0.2 and 6.3\ifmmode\pm\else\textpm\fi{}0.2\ifmmode\pm\else\textpm\fi{}0.2 are found for the semileptonic and nonleptonic charged multiplicities, respectively. If $b\ensuremath{\rightarrow}c$ dominance is assumed for the weak decay of the $B$ meson, then the semileptonic multiplicity is consistent with the recoil mass determined from the lepton momentum spectrum.

Using a sample of 484 000 B mesons collected with the CLEO detector at the Cornell Electron Storage Ring, we have measured B(B\ifmmode\bar\else\textasciimacron\fi{} $^{0}\mathrm{D}^{\mathrm{*}+}$${\mathrm{l}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\nu}) and found that the polarization of the ${D}^{\mathrm{*}+}$ is small. These results are compared with models of semileptonic B decay.

A detailed investigation of the decay $\ensuremath{\Upsilon}(2S)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\Upsilon}(1S)$ has been made from 128 000 $\ensuremath{\Upsilon}(2S)$ decays observed in the CLEO detector at the Cornell Electron Storage Ring (CESR). We find this branching ratio to be (19.1\ifmmode\pm\else\textpm\fi{}1.2\ifmmode\pm\else\textpm\fi{}0.6)%. The properties of the $\ensuremath{\pi}\ensuremath{\pi}$ system have been studied using 491 exclusive events of the type $\ensuremath{\Upsilon}(2S)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\Upsilon}(1S)$, $\ensuremath{\Upsilon}(1S)\ensuremath{\rightarrow}{e}^{+}{e}^{\ensuremath{-}} or {\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$. Assuming $e\ensuremath{-}\ensuremath{\mu}$ universality we find $B(\ensuremath{\Upsilon}(1S)\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}})=(2.84\ifmmode\pm\else\textpm\fi{}0.18\ifmmode\pm\else\textpm\fi{}0.20)$%. A search for $\ensuremath{\Upsilon}(2S)\ensuremath{\rightarrow}\ensuremath{\eta}\ensuremath{\Upsilon}(1S)$ yields an upper limit of 1% at the 90% confidence level for this branching ratio. We have also searched for $[\ensuremath{\Upsilon}(2S) or \ensuremath{\Upsilon}(3S)]\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\Upsilon}(1S)$, $\ensuremath{\Upsilon}(1S)\ensuremath{\rightarrow}\mathrm{noninteracting}\mathrm{particles}$.

We report on a search for the photoproduction of ${D}^{0}({\overline{D}}^{0})$ mesons in events which have zero total visible strangeness. We observe an enhancement of 94\ifmmode\pm\else\textpm\fi{}19 events in the ${K}^{\ifmmode\pm\else\textpm\fi{}}{\ensuremath{\pi}}^{\ensuremath{\mp}}$ decay mode, corresponding to a cross section of \ensuremath{\sim}720 nb assuming a branching ratio of 0.018.

Abstract Background Differentiation between neoplastic and reactive lymphocytic proliferations can be challenging in cats. PCR for antigen receptor rearrangements (PARR) testing is a useful diagnostic tool to assess clonality of a lymphoid population. Previous feline PARR studies evaluated clonality of complete immunoglobulin heavy chain V‐D‐J (IGH‐VDJ) and T‐cell receptor gamma (TRG) gene rearrangements. Objectives We aimed to evaluate the sensitivity and specificity of feline PARR primers targeting complete IGH‐VDJ and TRG rearrangements, as well as incomplete IGH‐DJ, kappa deleting element (Kde), and immunoglobulin lambda light chain (IGL) gene rearrangements in defined feline neoplasms and nonneoplastic controls. Methods Fluorescently labeled PCR primers were designed to amplify complete IGH‐VDJ, incomplete IGH‐DJ, Kde, IGL, and TRG gene rearrangements in two multiplexed PCR reactions, and PCR products were analyzed by fragment analysis. Fresh tissue samples from 12 flow cytometrically confirmed B‐cell lymphomas, 26 cytologically confirmed gastric and renal lymphomas of presumed B‐cell origin, 30 flow cytometrically confirmed T‐cell leukemias, and 11 negative control cats were tested. Results Using four immunoglobulin primer sets (IGH‐VDJ, IGH‐DJ, Kde, and IGL), clonal immunoglobulin rearrangements were detected in 87% (33/38) of the presumed B‐cell neoplasms. The IGH‐VDJ reaction alone only detected clonality in 50% (19/38) of these cases. TRG rearrangements were clonal in 97% (29/30) of the T‐cell leukemia cases. All negative control samples had polyclonal immunoglobulin and TRG rearrangements. Conclusions The PARR assay developed in this study is useful for assessing clonality in feline lymphoid neoplasms. Clonality assessment of incomplete IGH‐DJ, Kde, and IGL rearrangements helped identify clonal B‐cell neoplasms not detected with complete IGH‐VDJ PARR alone.

Using a sample of 3.3×106 Υ(4S)→B¯B events collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR), we measure B(→Bρlν), |Vub|, and the partial rate (ΔΓ) in three bins of q2≡(pB−pρ)2. We find B(B0→ρ−l+ν)=(2.69±0.41+0.35−0.40±0.50)×10−4, |Vub|=(3.23±0.24+0.23−0.26±0.58)×10−3, ΔΓ(0<q2<7GeV2/c4)=(7.6±3.0+0.9−1.2±3.0)×10−2ns−1, ΔΓ(7<q2<14GeV2/c4)=(4.8±2.9+0.7−0.8±0.7)×10−2ns−1, and ΔΓ(14<q2<21GeV2/c4)=(7.1±2.1+0.9−1.1±0.6)×10−2ns−1. Here, l=e or μ, but not both, and the errors are statistical, systematic, and theoretical. The method is sensitive primarily to →Bρlν decays with leptons in the energy range above 2.3 GeV. Averaging with the previously published CLEO results for →Bρlν, we obtain B(B0→ρ−l+ν)=(2.57±0.29+0.33−0.46±0.41)×10−4 and |Vub|=(3.25±0.14+0.21−0.29±0.55)×10−3. Received 24 May 1999DOI:https://doi.org/10.1103/PhysRevD.61.052001©2000 American Physical Society

We have studied two-body charmless hadronic decays of B mesons into the final states straight phiK and phiK(*). Using 9.7 million B&Bmacr; pairs collected with the CLEO II detector, we observe the decays B- --> phiK- and B0--> phiK(*0) with the following branching fractions: B(B--->phiK-) = (5.5(+2.1)(-1.8)+/-0.6)x10(-6) and B(B0--> phiK(*0)) = (11.5(+4.5+1.8)(-3.7-1.7))x10(-6). We also see evidence for the decays B0-->phiK0 and B---> phiK(*-). However, since the statistical significance is not overwhelming for these modes, we determine upper limits of <12.3x10(-6) and <22.5x10(-6) ( 90% confidence level), respectively.

We describe several measurements using the decays D 0 → K + K -and π + π -.We find the ratio of partial widths, Γ D 0 → K + K -/Γ D 0 → π + π -, to be 2.96 ± 0.16 ± 0.15, where the first error is statistical and the second is systematic.We observe no evidence for direct CP violation, obtaining A CP (KK) = (0.0 ± 2.2 ± 0.8)% and A CP (ππ) = (1.9 ± 3.2 ± 0.8)%.In the limit of no CP violation we measure the mixing parameter y CP = -0.012± 0.025 ± 0.

The decay ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}\ensuremath{\eta}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ has been observed with the CLEO II detector. The $\ensuremath{\eta}$ meson is reconstructed using two decay channels, $\ensuremath{\eta}\ensuremath{\rightarrow}\ensuremath{\gamma}\ensuremath{\gamma}$ and ${\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{0}$. The measured branching fraction is $B({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{K}^{\ensuremath{-}}\ensuremath{\eta}{\ensuremath{\nu}}_{\ensuremath{\tau}})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}(2.6\ifmmode\pm\else\textpm\fi{}0.5\ifmmode\pm\else\textpm\fi{}0.4)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$, somewhat higher than theoretical estimates. An improved upper limit for the second-class-current decay ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\eta}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ is set, $B({\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}\ensuremath{\eta}{\ensuremath{\nu}}_{\ensuremath{\tau}})&lt;1.4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$ at 95% C.L., consistent with theoretical expectations.

We have measured the CP asymmetry A(CP) identical with[gamma(b-->sgamma)-gammab-->sgamma)]/[gamma(b-->sgamma)+gamma(b-->sgamma)] to be A(CP) = (-0.079+/-0.108+/-0.022) (1.0+/-0.030), implying that, at 90% confidence level, A(CP) lies between -0.27 and +0.10. These limits rule out some extreme non-standard-model predictions, but are consistent with most, as well as with the standard model.

We consider the decay of \ensuremath{\Upsilon}(1S) particles produced at CESR into a photon which is observed by the CLEO detector plus particles which are not seen. These could be real particles which fall outside of our acceptance, or particles which are noninteracting. We report the results of our search fo the process \ensuremath{\Upsilon}(1S)\ensuremath{\rightarrow}\ensuremath{\gamma}+``unseen'' for photon energies &gt;1 GeV, obtaining limits for the case where ``unseen'' is either a single particle or a particle-antiparticle pair. Our upper limits represent the highest sensitivity measurements for such decays to date.

The Grid2003 Project has deployed a multivirtual organization, application-driven grid laboratory (Grid3) that has sustained for several months the production-level services required by physics experiments of the Large Hadron Collider at CERN (ATLAS and CMS), the Sloan Digital Sky Survey project, the gravitational wave search experiment LIGO, the BTeV experiment at Fermilab, as well as applications in molecular structure analysis and genome analysis, and computer science research projects in such areas as job and data scheduling. The deployed infrastructure has been operating since November 2003 with 27 sites, a peak of 2800 processors, work loads from 10 different applications exceeding 1300 simultaneous jobs, and data transfers among sites of greater than 2 TB/day. We describe the principles that have guided the development of this unique infrastructure and the practical experiences that have resulted from its creation and use. We discuss application requirements for grid services deployment and configuration, monitoring infrastructure, application performance, metrics, and operational experiences. We also summarize lessons learned.

We have studied the inclusive photon spectra in Upsilon(2S) and Υ(3S) decays using a large statistics data sample obtained with the CLEO III detector. We present the most precise measurements of electric dipole (E1) photon transition rates and photon energies for Upsilon(2S)-&gt;gamma chi_bJ(1P) and Upsilon(3S)-&gt;gamma chi_bJ(2P) J=0,1,2. We measure the rate for a rare E1 transition Upsilon(3S)-&gt;gamma chi_b0(1P) for the first time. We also set upper limits on the rates for the hindered magnetic dipole (M1) transitions to the eta_b(1S) and eta_b(2S) states.

We have investigated the transitions \ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}${\ensuremath{\pi}}^{+}$${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\Upsilon}(1S) and \ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}${\ensuremath{\pi}}^{+}$${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\Upsilon}(2S) and the cascade process \ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}\ensuremath{\Upsilon}(2S)+X, \ensuremath{\Upsilon}(2S)\ensuremath{\rightarrow}${\ensuremath{\pi}}^{+}$${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\Upsilon}(1S), both in the exclusive decay mode where the daughter \ensuremath{\Upsilon} state decays into two leptons, and in the inclusive decay mode where the daughter \ensuremath{\Upsilon} state decays hadronically. Results are presented on branching fractions and the properties of the ${\ensuremath{\pi}}^{+}$${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$ system. Possible evidence for the transition \ensuremath{\Upsilon}(3S)\ensuremath{\rightarrow}${\ensuremath{\pi}}^{+}$${\ensuremath{\pi}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\Upsilon}${(1}^{1}$${P}_{1}$) is presented.

The decay ${\mathrm{\ensuremath{\tau}}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\rightarrow}${\ensuremath{\nu}}_{\mathrm{\ensuremath{\tau}}}$${\mathrm{\ensuremath{\pi}}}^{\mathrm{\ensuremath{-}}}$${\mathrm{\ensuremath{\pi}}}^{0}$\ensuremath{\eta} has been observed for the first time using the CLEO-II detector at the Cornell Electron Storage Ring. The measured branching ratio (0.17\ifmmode\pm\else\textpm\fi{}0.02\ifmmode\pm\else\textpm\fi{}0.02)%, agrees with the CVC (conserved vector current) prediction based on ${\mathit{e}}^{+}$${\mathit{e}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\rightarrow}${\mathrm{\ensuremath{\pi}}}^{+}$${\mathrm{\ensuremath{\pi}}}^{\mathrm{\ensuremath{-}}}$\ensuremath{\eta} data. Upper limits on the branching ratios for other \ensuremath{\tau} decays to final states including \ensuremath{\eta} mesons are improved by an order of magnitude compared to previous measurements.

We have studied the inclusive photon spectrum in psi(2S) decays using the CLEO III detector. We present the most precise measurements of electric dipole (E1) photon transition rates for psi(2S)--> gamma chicJ(1P) (J=0,1,2). We also confirm the hindered magnetic dipole (M1) transition, psi(2S)-->gamma etac(1S). However, the direct M1 transition psi(2S)-->gamma etac(2S) observed by the Crystal Ball as a narrow peak at a photon energy of 91 MeV is not found in our data.

The authors provide a review of current knowledge of lymphocytosis in nonneoplastic conditions. They conclude that the list of major differentials for persistent nonneoplastic lymphocyte expansion in dogs and cats is short and that most of these conditions are relatively uncommon. Persistent lymphocytosis of small, mature, or reactive lymphocytes is most commonly the result of chronic lymphocytic leukemia or lymphoma. The first step in distinguishing nonneoplastic from neoplastic lymphocytosis is immunophenotyping by flow cytometry to determine the phenotypic diversity of the circulating cells. Clonality testing using the polymerase chain reaction for antigen receptor rearrangements assay is a useful second step in cases in which the phenotype data are equivocal. Once the diagnosis of malignancy has been established, the immunophenotype also provides prognostic information in dogs.

We investigate the decays D(0)-->pi(-)l(+)nu and D(0)-->K(-)l(+)nu, where l is e or mu, using approximately 7 fb(-1) of data collected with the CLEO III detector. We find R(0) identical with B(D(0)-->pi(-)e(+)nu)/B(D(0)-->K(-)e(+)nu)=0.082+/-0.006+/-0.005. Fits to the kinematic distributions of the data provide parameters describing the form factor of each mode. Combining the form factor results and R(0) gives |f(pi)(+)(0)|(2)|V(cd)|(2)/|f(K)(+)(0)|(2)|V(cs)|(2)=0.038(+0.006+0.005)(-0.007-0.003).

We have measured upper limits on branching fractions for rare exclusive decays of B mesons arising from one-loop diagrams in the standard model of electroweak interactions. We also obtain an upper limit for the lepton-number-violating decay B0→μ±e∓.

Various exclusive and inclusive decays of $B$ mesons have been studied using data taken with the CLEO detector at the Cornell Electron Storage Ring. The exclusive modes examined are mostly decays into two hadrons. The branching ratio for a $B$ meson to decay into a charmed meson and a charged pion is found to be about 2%. Upper limits are quoted for other final states $\ensuremath{\psi}{K}^{\ensuremath{-}}$, ${\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}$, ${\ensuremath{\rho}}^{0}{\ensuremath{\pi}}^{\ensuremath{-}}$, ${\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$, ${e}^{+}{e}^{\ensuremath{-}}$, and ${\ensuremath{\mu}}^{\ifmmode\pm\else\textpm\fi{}}{e}^{\ensuremath{\mp}}$. We also give an upper limit on inclusive $\ensuremath{\psi}$ production and improved charged multiplicity measurements.

Using CLEO data, we study the production of the antideuteron, ¯d, in Υ(nS) resonance decays and the nearby continuum. The branching ratios obtained are Bdir(Υ(1S)→¯dX)=(3.36±0.23±0.25)×10−5, B(Υ(1S)→¯dX)=(2.86±0.19±0.21)×10−5, and B(Υ(2S)→¯dX)=(3.37±0.50±0.25)×10−5, where the "dir" superscript indicates that decays produced via reannihilation of the b¯b pair to a γ∗ are removed from both the signal and the normalizing number of Υ(1S) decays in order to isolate direct decays of the Υ(1S) to ggg, ggγ. Upper limits at 90% C.L. are given for B(Υ(4S)→¯dX)<1.3×10−5, and continuum production σ(e+e−→¯dX)<0.031 pb. The Υ(2S) data is also used to extract a limit on χbJ→¯dX. The results indicate enhanced deuteron production in ggg, ggγ hadronization compared to γ∗→q¯q. Baryon number compensation is also investigated with the large Υ(1S)→¯dX sample.Received 10 December 2006DOI:https://doi.org/10.1103/PhysRevD.75.012009©2007 American Physical Society

Cytology is commonly used to diagnose lymphoma and leukemia. Frequently, a diagnosis of lymphoproliferative disease can be obtained via cytology, and some of the common subtypes of canine lymphoma and leukemia can have characteristic cytologic features. Flow cytometry is a critical tool in the objective diagnosis and further characterization of lymphoma and leukemia. Features of the immunophenotype, such as expression of certain cell surface proteins or cell size, can provide important prognostic information. This review describes the cytologic features, flow cytometry immunophenotype, and immunophenotypic prognostic information for 6 major types of canine lymphoma and leukemia.

Using data recorded by the CLEO II detector at CESR, we report evidence for two new charmed baryons, one decaying into $\Xi_c^+\pi^+\pi^-$ via an intermediate $\Xi_c^{*0}$, and its isospin partner decaying into $\Xi_c^0\pi^+\pi^-$ via an intermediate $\Xi_c^{*+}$. We measure the mass differences of the two states to be $M(\Xi_c^+\pi^+\pi^-)-M(\Xi_c^+)=$ $348.6\pm0.6\pm1.0$ MeV, and $M(\Xi_c^0\pi^+\pi^-)-M(\Xi_c^0)=$ $347.2\pm0.7\pm2.0$ MeV. We interpret these new states as the $J^P = {3 \over{2}}^- $ $\Xi_{c1}$ particles, the charmed-strange analogues of the $\Lambda_{c1}^+(2625)$.

Using a sample of 3.3 million B-meson decays collected with the CLEO detector at the Cornell Electron Storage Ring, we have studied $B^- \to D^0 \ell\nu$ and $\bar{B}^0 \to D^+ \ell\nu$ decays, where $\ell$ can be either an electron or muon. We distinguish $B \to D \ell\nu$ from other B semileptonic decays by examining the net momentum and energy of the particles recoiling against the D-lepton pairs. We find the decay rate $\Gamma(B \to D\ell\nu)$ = (14.1 +- 1.0 +- 1.2) ns-1 and derive branching fractions for $B^- \to D^0 \ell\nu$ and $\bar{B^0} \to D^+ \ell\nu$ of (2.32 +- 0.17 +- 0.20)% and 2.20 +- 0.16 +- 0.19)% respectively, where the uncertainties are statistical and systematic. We also investigate the $B \to D \ell\nu$ form factor and the implication of the result for $|V_{cb}|$.

Although lymphoma and leukemia usually can be diagnosed by routine cytology and histology, some cases present a diagnostic challenge for pathologists and clinicians. Often the dilemma lies in determining whether a population of lymphocytes is reactive or neoplastic. We review currently available methods for analyzing lymphocyte populations by immunophenotyping and by identifying clonally rearranged immunoglobulin and T-cell receptor genes and discuss how these tests can be used to clarify such diagnostic dilemmas. We also describe the detection of chromosomal abnormalities and methods on the horizon, such as gene expression profiling, to identify diagnostically useful oncogenes. Finally, we review the emerging concept of transitional neoplastic states, in which reactive lymphocytes transform to neoplastic lymphocytes in the presence of continued antigenic stimulation, such as that caused by infection with Helicobacter pylori. The existence of transitional neoplastic states underscores the need for an array of molecular diagnostic tools that would improve our ability to characterize lymphocyte populations in human and animal patients and enhance early detection of neoplastic lymphocytes such that eradication of the infectious or inflammatory stimulus could lead to cure.

Using the CLEO detector at the Cornell Electron Storage Ring, we observe B-meson decays to Λc+ and report on improved measurements of inclusive branching fractions and momentum spectra of other baryons. For the inclusive decay B¯→Λc+X with Λc+→pK−π+, we find that the product branching fraction B(B¯→Λc+X)B(Λc+→pK−π+)=(0.273±0.051±0.039)%. Our measured inclusive branching fractions to noncharmed baryons are B(B→pX)=(8.0±0.5±0.3)%, B(B→ΛX)=(3.8±0.4±0.6)%, and B(B→Ξ−X)=(0.27±0.05±0.04)%. From these rates and studies of baryon-lepton and baryon-antibaryon correlations in B decays, we have estimated the branching fraction B(B¯→Λc+X) to be (6.4±0.8±0.8)%. Combining these results, we calculate B(Λc+→pK−π+) to be (4.3±1.0±0.8)%.Received 15 April 1991DOI:https://doi.org/10.1103/PhysRevD.45.752©1992 American Physical Society

We have studied the color-suppressed hadronic decays of neutral B mesons into the final states ${D}^{(*)0}{\ensuremath{\pi}}^{0}$. Using $9.67\ifmmode\times\else\texttimes\fi{}{10}^{6}$ $B\overline{B}$ pairs collected with the CLEO detector, we observe the decays ${\overline{B}}^{0}\ensuremath{\rightarrow}{D}^{0}{\ensuremath{\pi}}^{0}$ and ${\overline{B}}^{0}\ensuremath{\rightarrow}{D}^{*0}{\ensuremath{\pi}}^{0}$ with the branching fractions $B({\overline{B}}^{0}\ensuremath{\rightarrow}{D}^{0}{\ensuremath{\pi}}^{0})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}({2.74}_{\ensuremath{-}0.32}^{+0.36}\ifmmode\pm\else\textpm\fi{}0.55)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$ and $B({\overline{B}}^{0}\ensuremath{\rightarrow}{D}^{*0}{\ensuremath{\pi}}^{0})\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}({2.20}_{\ensuremath{-}0.52}^{+0.59}\ifmmode\pm\else\textpm\fi{}0.79)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$. The first error is statistical and the second systematic. The statistical significance of the ${D}^{0}{\ensuremath{\pi}}^{0}$ signal is $12.1\ensuremath{\sigma}$ ( $5.9\ensuremath{\sigma}$ for ${D}^{*0}{\ensuremath{\pi}}^{0}$). Utilizing the ${\overline{B}}^{0}\ensuremath{\rightarrow}{D}^{(*)0}{\ensuremath{\pi}}^{0}$ branching fractions we determine the strong phases ${\ensuremath{\delta}}_{I,D(*)}$ between isospin $1/2$ and $3/2$ amplitudes in the $D\ensuremath{\pi}$ and ${D}^{*}\ensuremath{\pi}$ final states to be $\mathrm{cos}{\ensuremath{\delta}}_{I,D}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.89\ifmmode\pm\else\textpm\fi{}0.08$ and $\mathrm{cos}{\ensuremath{\delta}}_{I,D*}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}0.89\ifmmode\pm\else\textpm\fi{}0.08$, respectively.

The Grid2003 Project has deployed a multivirtual organization, application-driven grid laboratory ("Grid3") that has sustained for several months the production-level services required by physics experiments of the Large Hadron Collider at CERN (ATLAS and CMS), the Sloan Digital Sky Survey project, the gravitational wave search experiment LIGO, the BTeV experiment at Fermilab, as well as applications in molecular structure analysis and genome analysis, and computer science research projects in such areas as job and data scheduling. The deployed infrastructure has been operating since November 2003 with 27 sites, a peak of 2800 processors, work loads from 10 different applications exceeding 1300 simultaneous jobs, and data transfers among sites of greater than 2 TB/day. We describe the principles that have guided the development of this unique infrastructure and the practical experiences that have resulted from its creation and use. We discuss application requirements for grid services deployment and configuration, monitoring infrastructure, application performance, metrics, and operational experiences. We also summarize lessons learned.

From electron-positron collision data collected with the CLEO detector operating at Cornell Electron Storage Ring near sqrt[s]=10.6 GeV, improved measurements of the branching fractions for tau decays into three explicitly identified hadrons and a neutrino are presented as B(tau(-)-->pi(-)pi(+)pi(-)nu(tau))=(9.13+/-0.05+/-0.46)%, B(tau(-)-->K-pi(+)pi(-)nu(tau))=(3.84+/-0.14+/-0.38) x 10(-3), B(tau(-)-->K-K+pi(-)nu(tau))=(1.55+/-0.06+/-0.09) x 10(-3), and B(tau(-)-->K-K+K-nu(tau))<3.7 x 10(-5) at 90% C.L., where the uncertainties are statistical and systematic, respectively.

We report a measurement of \ensuremath{\Lambda} polarization in the two-body decay ${\mathrm{\ensuremath{\Lambda}}}_{\mathit{c}}^{+}$\ensuremath{\rightarrow}\ensuremath{\Lambda}${\mathrm{\ensuremath{\pi}}}^{+}$, in nonresonant ${\mathit{e}}^{+}$${\mathit{e}}^{\mathrm{\ensuremath{-}}}$ interactions from data taken with the CLEO detector. Using these data we have determined the parity-violating asymmetry decay parameter ${\mathrm{\ensuremath{\alpha}}}_{\mathrm{\ensuremath{\Lambda}}\mathit{c}}$ to be -1.${0}_{\mathrm{\ensuremath{-}}0.0}^{+0.4}$. We see no evidence for significant ${\mathrm{\ensuremath{\Lambda}}}_{\mathit{c}}^{+}$ polarization.

Using CLEO data collected from CESR e+e− collisions at the ψ(2S) resonance and nearby continuum at √s=3.67 GeV, we report the first significantly nonzero measurements of light vector-pseudoscalar hadron pair production (including ρπ, ωπ, ρη, and K*0¯¯¯¯¯K0) and the π+π−π0 final state, both from ψ(2S) decays and direct e+e− annihilation.Received 14 July 2004DOI:https://doi.org/10.1103/PhysRevLett.94.012005©2005 American Physical Society

We present a measurement of the composition of B meson inclusive semileptonic decays using 9.4 ${\mathrm{fb}}^{\mathrm{\ensuremath{-}}1}$ of ${e}^{+}{e}^{\ensuremath{-}}$ data taken with the CLEO detector at the $\ensuremath{\Upsilon}(4S)$ resonance. In addition to measuring the charged lepton kinematics, the neutrino four-vector is inferred using the hermiticity of the detector. We perform a maximum likelihood fit over the full three-dimensional differential decay distribution for the fractional contributions from the $\stackrel{\ensuremath{\rightarrow}}{B}{X}_{c}\mathcal{l}\ensuremath{\nu}$ processes with ${X}_{c}=D,$ ${D}^{*},$ ${D}^{**},$ and nonresonant ${X}_{c},$ and the process $\stackrel{\ensuremath{\rightarrow}}{B}{X}_{u}\mathcal{l}\ensuremath{\nu}.$ From the fit results we extract the first and second moments of the ${M}_{X}^{2}$ and ${q}^{2}$ distributions with minimum lepton-energy requirements of 1.0 GeV and 1.5 GeV. We find $〈{M}_{X}^{2}\ensuremath{-}{M}_{D}^{2}〉=(0.456\ifmmode\pm\else\textpm\fi{}0.014\ifmmode\pm\else\textpm\fi{}0.045\ifmmode\pm\else\textpm\fi{}0.109){\mathrm{GeV}}^{2}{/c}^{4}$ with a minimum lepton energy of 1.0 GeV and $〈{M}_{X}^{2}\ensuremath{-}{M}_{D}^{2}〉=(0.293\ifmmode\pm\else\textpm\fi{}0.012\ifmmode\pm\else\textpm\fi{}0.033\ifmmode\pm\else\textpm\fi{}0.048){\mathrm{GeV}}^{2}{/c}^{4}$ with minimum lepton energy of 1.5 GeV. The uncertainties are from statistics, detector systematic effects, and model dependence, respectively. As a test of the HQET and OPE calculations, the results for the ${M}_{X}^{2}$ moment as a function of the minimum lepton energy requirement are compared to the predictions.

From e+e− collision data acquired with the CLEO detector at the Cornell Electron Storage Ring, we observe the non-D¯¯¯D decay ψ(3770)→γχc1 with a statistical significance of 6.6 standard deviations, using the two-photon cascades to J/ψ and J/ψ→ℓ+ℓ−. We determine σ(e+e−→ψ(3770))×B(ψ(3770)→γχc1)=(18.0±3.3±2.5) pb and branching fraction B(ψ(3770)→γχc1)=(2.8±0.5±0.4)×10−3. We set 90% C.L. upper limits for the transition to χc2 (χc0): σ×B<5.7 pb (<282 pb) and B<0.9×10−3 (<44×10−3). We also determine Γ(ψ(3770)→γχc1)/Γ(ψ(3770)→π+π−J/ψ)=1.5±0.3±0.3 (>1.0 at 90% C.L.), which bears upon the interpretation of X(3872).Received 21 September 2005DOI:https://doi.org/10.1103/PhysRevLett.96.182002©2006 American Physical Society

We report the results of a new search for flavor-changing neutral-current decays of the b quark and present a 90%-confidence-level upper limit for the branching fraction for B\ensuremath{\rightarrow}${l}^{+}$${l}^{\mathrm{\ensuremath{-}}}$X of 1.2\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}3}$.

We have observed a signal for the decay ${D}^{0}\ensuremath{\rightarrow}\ensuremath{\varphi}{\overline{K}}^{0}$. We find that a broad threshold enhancement in the ${K}^{+}{K}^{\ensuremath{-}}$ mass spectrum in the decay ${D}^{0}\ensuremath{\rightarrow}{K}^{+}{K}^{\ensuremath{-}}{\overline{K}}^{0}$ is the main source of background to the ${D}^{0}\ensuremath{\rightarrow}\ensuremath{\varphi}{\overline{K}}^{0}$ signal. Accounting for this background, we obtain the branching fraction $B({D}^{0}\ensuremath{\rightarrow}\ensuremath{\varphi}{\overline{K}}^{0})=(1.18\ifmmode\pm\else\textpm\fi{}0.40\ifmmode\pm\else\textpm\fi{}0.17)%$.

We report on the observation of exclusive decays of B mesons to modes containing a D or ${D}^{\mathrm{*}+}$ and one or two charged pions. From kinematic reconstruction we determine the masses of the neutral and charged B mesons to be 5280.6\ifmmode\pm\else\textpm\fi{}0.8\ifmmode\pm\else\textpm\fi{}2.0 and 5278.6\ifmmode\pm\else\textpm\fi{}0.8\ifmmode\pm\else\textpm\fi{}2.0 MeV, respectively. The mass difference is 2.0\ifmmode\pm\else\textpm\fi{}1.1\ifmmode\pm\else\textpm\fi{}0.3 MeV. Branching ratios for these modes are given. From the charged-particle momentum spectrum in \ensuremath{\Upsilon}(4S) decay, we find the average branching fraction for B-meson decay into a D or ${D}^{\mathrm{*}}$ plus a charged pion to be (0.81\ifmmode\pm\else\textpm\fi{}0.16)%. We find no signal for exclusive decays which would arise from the b\ensuremath{\rightarrow}u transition and set upper limits for several such modes.

A measurement is presented of the inclusive production of charged D* and neutral D mesons from nonresonant e+e− annihilation in the energy region near the ϒ(4S) resonance. The momentum distribution shows a large contribution at high momenta as expected for heavy quark production. Comparison of the spectrum with several phenomenological models is made. The relative yields of the D* and D mesons indicate that the charm cross section is dominated by the D* contribution.Received 21 July 1983DOI:https://doi.org/10.1103/PhysRevLett.51.1139©1983 American Physical Society

Interleukin-12 (IL-12), a proinflammatory cytokine, shows anticancer properties. Systemically administered IL-12 causes dose-dependent toxicity. To achieve localized intratumoral gene expression, an adenoviral gene therapy vector with IL-12 controlled by a heat-inducible promoter (heat shock promoter 70B) was developed and tested in a phase I clinical trial in cats with spontaneously arising soft tissue sarcoma. A feasibility study was done in 16 cats with soft tissue sarcoma using murine IL-12 and/or enhanced green fluorescent protein adenoviral vectors under cytomegalovirus or heat shock promoter 70 control. Subsequently, we conducted a phase I clinical trial using an adenoviral feline IL-12 construct in 13 cats with soft tissue sarcoma. The soft tissue sarcomas were irradiated (48 Gy/16 fractions) followed by intratumoral injection of adenovirus. Twenty-four hours postinjection, tumors were heated (41 degrees C, 60 min). Tumor expression of feline IL-12 and IFN-gamma was determined. Cats were monitored for systemic toxicity. For the murine IL-12 construct, an association was noted between viral dose and murine IL-12 levels within tumor, whereas serum levels were minimal. Mild toxicity was noted at 10(11) plaque-forming units (pfu). With the feline IL-12 construct, high levels of feline IL-12 mRNA were detected in tumor biopsies with low or absent IFN-gamma mRNA following gene therapy. Hematologic and hepatic toxicities were noted at the highest viral doses and were associated with detection of IFN-gamma mRNA in tumor. It is possible to localize gene expression and limit systemic toxicity of IL-12 using the hyperthermia-induced gene therapy approach. The maximum tolerated dose of the feline IL-12 adenoviral vector was 10(10) pfu/tumor as dose-limiting toxicities were noted at the 4 x 10(10) pfu dose.

We describe new measurements of the inclusive and exclusive branching fractions for ψ(2S) transitions to J/ψ using e+e− collision data collected with the CLEO detector operating at CESR. All branching fractions and ratios of branching fractions reported here represent either the most precise measurements to date or the first direct measurements. Indirectly and in combination with other CLEO measurements, we determine B(χcJ→γJ/ψ) and B[ψ(2S)→light hadrons].Received 16 March 2005DOI:https://doi.org/10.1103/PhysRevLett.94.232002©2005 American Physical Society