Miloš Đorđević

The scientific community shows a great interest in the study of DNA damage induction, DNA damage repair and the biological effects on cells and cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far to study these mechanisms using Monte Carlo simulations. This study outlines a Geant4-DNA example application, named "molecularDNA", publicly released in the 11.1 version of Geant4 (December 2022). It was developed for novice Geant4 users and requires only a basic understanding of scripting languages to get started. The example currently proposes two different DNA-scale geometries of biological targets, namely "cylinders", and the "human cell". This public version is based on a previous prototype and includes new features such as: the adoption of a new approach for the modeling of the chemical stage (IRT-sync), the use of the Standard DNA Damage (SDD) format to describe radiation-induced DNA damage and upgraded computational tools to estimate DNA damage response. Simulation data in terms of single strand break (SSB) and double strand break (DSB) yields were produced using each of these geometries. The results were compared to the literature, to validate the example, producing less than 5 % difference in all cases.

<h2>Abstract</h2><h3>Purpose:</h3> Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a Geant4-DNA radiobiological application by incorporating a feature allowing for the prediction of DNA rejoining kinetics and corresponding cell surviving fraction along time after irradiation, for a Chinese hamster V79 cell line, which is one of the most popular and widely investigated cell lines in radiobiology. <h3>Methods:</h3> We implemented the Two-Lesion Kinetics (TLK) model, originally proposed by Stewart, which allows for simulations to calculate residual DNA damage and surviving fraction along time via the number of initial DNA damage and its complexity as inputs. <h3>Results:</h3> By optimizing the model parameters of the TLK model in accordance to the experimental data on V79, we were able to predict both DNA rejoining kinetics at low linear energy transfers (LET) and cell surviving fraction. <h3>Conclusion:</h3> This is the first study to demonstrate the implementation of both the cell surviving fraction and the DNA rejoining kinetics with the estimated initial DNA damage, in a realistic cell geometrical model simulated by full track structure MC simulations at DNA level and for various LET. These simulation and model make the link between mechanistic physical/chemical damage processes and these two specific biological endpoints.

Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application "molecularDNA", an example for users of Geant4-DNA, will soon be distributed through Geant4.

Purpose:This study aimed to develop a computational environment for the accurate simulation of human cancer cell irradiation using Geant4-DNA. New cell geometrical models were developed and irradiated by alpha particle beams to induce DNA damage. The proposed approach may help further investigation of the benefits of external alpha irradiation therapy.Methods:The Geant4-DNA Monte Carlo (MC) toolkit allows the simulation of cancer cell geometries that can be combined with accurate modelling of physical, physicochemical and chemical stages of liquid water irradiation, including radiolytic processes. Geant4-DNA is used to calculate direct and non-direct DNA damage yields, such as single and double strand breaks, produced by the deposition of energy or by the interaction of DNA with free radicals.Results:In this study, the “molecularDNA” example application of Geant4-DNA was used to quantify early DNA damage in human cancer cells upon irradiation with alpha particle beams, as a function of linear energy transfer (LET). The MC simulation results are compared to experimental data, as well as previously published simulation data. The simulation results agree well with the experimental data on DSB yields in the lower LET range, while the experimental data on DSB yields are lower than the results obtained with the “molecularDNA” example in the higher LET range.Conclusion:This study explored and demonstrated the possibilities of the Geant4-DNA toolkit together with the “molecularDNA” example to simulate the helium beam irradiation of cancer cell lines, to quantify the early DNA damage, or even the following DNA damage response.

The slewing platform is the fundamental part of the bucket wheel excavator (BWE) structure. The occurrence and propagation of cracks in the zones of the slewing platform mantle holes, may probably lead to BWE collapse. The goals of the study presented in the paper were to: (1) Diagnose the cause of cracks occurrence; (2) Define the reconstruction design of the mantle; (3) Verify the reconstructed structure by numerical–experimental analysis. The identification of the stress–strain state of the mantle is done by applying the finite element method. Experimental stress analysis of the reconstructed mantle's structure is executed two times in the BWE real working conditions, using methods of strain gauges. The maximum measured value of stress is about 10% lower in relation to the calculated value of stress for the studied load case. Speaking from the engineering standpoint, the mentioned deviation is quite acceptable, particularly having in mind the stochastic character of the excavation process. Besides experimental investigations, the validity of the presented reconstruction also unquestionably confirms the mentioned failure-free exploitation, while the BWE excavated more than 2.6 × 106 t of coal after the reconstruction.

The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams.A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC "Hadrontherapy" Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study.Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above.This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.

We conducted a comprehensive investigation to examine the electron-phonon interaction in semiconductor crystals of Zn1-xCdxGeAs2, where x ranges from 0 to 1. For this objective, X-ray diffraction, far-infrared reflection, and Raman scattering studies were employed. The study of the acquired results, based on fitting processes, provides a more comprehensive understanding of the structural, vibrational, and electronic properties, as well as their relationship to one another. In addition to the two primary phases, namely ZnGeAs2 and CdGeAs2, four component phases were also identified: ZnAs2, CdAs2, GeAs, and GeAs2. An uneven distribution of charge carriers was observed, with the greatest density seen in close proximity to the GeAs formation. The examination of the far-infrared reflection spectrum of ZnGeAs2 (x = 0) demonstrated the presence of a plasmon-4 phonon interaction, whereas in CdGeAs2 (x = 1), a plasmon-3 phonon interaction was seen. All other samples have both of these interactions, according to their percentage in the composition. It was found through Raman measurements that the intensity of phonon modes increases, they shift in energy, or they split into two modes because of the action of free charge carriers and electron-phonon interaction. The tests and results showed that the material had different phases, an uneven charge distribution, and electron-phonon interactions, all of which are important features of thermoelectric materials.

Stacker ARs 2000 presents the final link in the system for continuous overburden removal in the open pit mine “Kostolac” – Serbia. Its superstructure leans on three crawlers of the same length, width and height. During the stacker's travel from the erection site to the open pit mine, three crawler chain links fractured, presenting an indication of the problems that were to occur during exploitation. In fact, after only 1000 working hours (about three months), 30 chain links sustained fractures resulting in direct and indirect costs due to the downtime that substantially diminished the effects of the overburden removal system. The goal of the study presented in the paper was to diagnose the cause of chain link breakdown occurrence. Working stresses in the chain link are defined by applying FEM. Experimental investigations define the chemical composition, the tensile properties, the impact toughness and the macro and microhardness. Metallographic examinations are conducted additionally. Based on the results of the numerical-experimental analysis, it can be concluded that chain link breakdown is predominantly caused by (a) substantial deviation of the mechanical properties of the material with respect to those prescribed by the standard and (b) the existence of macro and microcracks in the material structure.

The performance of electromagnetic calorimeter modules made of proton-irradiated PbWO4 crystals has been studied in beam tests. The modules, similar to those used in the Endcaps of the CMS electromagnetic calorimeter (ECAL), were formed from 5×5 matrices of PbWO4 crystals, which had previously been exposed to 24 GeV protons up to integrated fluences between 2.1× 1013 and 1.3× 1014 cm−2. These correspond to the predicted charged-hadron fluences in the ECAL Endcaps at pseudorapidity η = 2.6 after about 500 fb−1 and 3000 fb−1 respectively, corresponding to the end of the LHC and High Luminosity LHC operation periods. The irradiated crystals have a lower light transmission for wavelengths corresponding to the scintillation light, and a correspondingly reduced light output. A comparison with four crystals irradiated in situ in CMS showed no significant rate dependence of hadron-induced damage. A degradation of the energy resolution and a non-linear response to electron showers are observed in damaged crystals. Direct measurements of the light output from the crystals show the amplitude decreasing and pulse becoming faster as the fluence increases. The latter is interpreted, through comparison with simulation, as a side-effect of the degradation in light transmission. The experimental results obtained can be used to estimate the long term performance of the CMS ECAL.

Recent LHC results on the appearance of sub-leading flow modes in PbPb collisions at 2.76~TeV, related to initial-state fluctuations, are analyzed and interpreted within the HYDJET++ model. Using the newly introduced Principal Component Analysis (PCA) method applied to two-particle azimuthal correlations extracted from the model calculations, the leading and the sub-leading flow modes are studied as a function of the transverse momentum ($p_{T}$) over a wide centrality range. The leading modes of the elliptic ($v^{(1)}_{2}$) and triangular ($v^{(1)}_{3}$) flow calculated within the HYDJET++ model reproduce rather well the $v_{2}\{2\}$ and $v_{3}\{2\}$ coefficients experimentally measured using the two-particle correlations. Within the $p_{T} \le $~3~GeV/c range where hydrodynamics dominates, the sub-leading flow effects are greatest at the highest $p_{T}$ of around 3~GeV/c. The sub-leading elliptic flow mode ($v^{(2)}_{2}$), which corresponds to $n = 2$ harmonic, has a small non-zero value and slowly increases from central to peripheral collisions, while the sub-leading triangular flow mode ($v^{(2)}_{3}$), which corresponds to $n = 3$ harmonic, is even smaller and does not depend on centrality. For $n = $~2, the relative magnitude of the effect measured with respect to the leading flow mode shows a shallow minimum for semi-central collisions and increases for very central and for peripheral collisions. For $n = $~3 case, there is no centrality dependence. The sub-leading flow mode results obtained from the HYDJET++ model are in a rather good agreement with the experimental measurements of the CMS Collaboration.

Correlations between azimuthal anisotropy Fourier harmonics ${v}_{n}$ ($n=2,3,4$) are studied using the events from PbPb collisions at $\sqrt{{s}_{{}_{\mathrm{NN}}}}=2.76$ TeV generated by the $\text{HYDJET}++$ and multiphase transport (AMPT) models, and compared to the corresponding experimental results obtained by the ATLAS Collaboration. The Fourier harmonics ${v}_{n}$ are measured over a wide centrality range using the two-particle azimuthal correlation method. The slopes of the ${v}_{2}\text{\ensuremath{-}}{v}_{3}$ correlation from both models are in a good agreement with the ATLAS data. The $\text{HYDJET}++$ model predicts a stronger slope for the ${v}_{2}\text{\ensuremath{-}}{v}_{4}$ and ${v}_{3}\text{\ensuremath{-}}{v}_{4}$ correlations than the ones experimentally measured, while the results from the AMPT model are in a rather good agreement with the experimental results. In contrast to the $\text{HYDJET}++$ predictions, the AMPT model predicts a boomeranglike shape in the structure of the correlations as found in the experimental data.

With a special focus on the now widespread Internet of Things (IoT) technology, it offers a convenient solution for smart agriculture. This paper will introduce a smart greenhouse monitoring and control data logger system as part of a smart farm. The system is based on: a group of built-in sensors, a microcontroller with a peripheral interface (PIC) as a core and a server system and a wireless Internet using the Global System of Mobile Telecommunications (GSM) module with General Packet Radio Service (GPRS) as a communication protocol. It is possible to implement a smart agricultural service, in which the realized smart data logger system could be implemented, which enables automatic control of the greenhouse at the farm.

As one of the deadliest forms of skin cancers, malignant melanoma is the most common cause of death from this type of cancer. Malignant melanoma has a steadily increasing incidence and the medical treatment options are still quite limited. One of the possible options for malignant melanoma treatment is medication therapy. The present study is focused on the development of new compounds that can be possibly used for malignant melanoma treatment. A newly synthesized series of alkylaminoethyl derivatives of androstane 3-oximes expressed significant cytotoxic activity towards malignant melanoma cells. This was an excellent basis for the development of quantitative structure-activity relationship (QSAR) models for the prediction of cytotoxic activity of not yet synthesized compounds. Also, on the basis of the cytotoxic activity data the molecular docking and molecular dynamics analysis were carried out. This local QSAR modeling, which is based on a limited set of structurally similar compounds, resulted in one univariate linear regression model, four multiple linear regression models and five support vector machines models. All of the models were confirmed to be statistically reliable with quite good prediction ability. The results of comparative molecular docking and molecular dynamics analysis indicated a high binding potential of novel compounds in regards to cisplatin as well-known chemotherapy drug. The established QSAR models and the results of molecular docking and molecular dynamics can be considered to be the guidelines for the design of new compounds worth synthesizing as potential lead compounds for malignant melanoma treatment.

More than a decade has passed since the start of the operation of the Large Hadron Collider at CERN and the discovery of the Higgs boson by the ATLAS and CMS Collaborations.The so far observed Higgs boson decay modes cover around 90% of the total Higgs boson width.The rare and yet unobserved Higgs boson decay channels could potentially be affected by the new physics, beyond the Standard Model.It is then crucial to search for these experimentally challenging decay modes in order to have a more complete characterisation of the Higgs boson physics sector.This was enabled with LHC Run 2 data having both increase in the Higgs production rate, with increased energy, and also the increase in the recorded luminosity.Both ATLAS and CMS have refined and advanced their analysis techniques, contributing further to increase in Higgs analyses sensitivity.

The CMS experiment at CERN uses a two-level triggering system that is composed of the Level-1 (L1), instrumented by custom-designed electronics with an output rate of 100 kHz, and the High Level Trigger (HLT), a streamlined version of the offline software reconstruction running on a computer farm, with around 1.5 kHz of physics rate stored for further analysis. New trigger algorithms and also new features, as well as an optimized trigger menu at the HLT, are essential in order to be able to successfully record events at higher data loads due to increasing luminosity and pileup at the LHC in Run 3 which has just started. Many measurements and searches will profit from the updates implemented in the CMS trigger. The highlights of Run 2 CMS trigger results will be presented in this proceedings, together with improvements for Run 3.

The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-defined human cell geometries and it can be used to calculate the early direct and non-direct DNA damage such as single (SSB) and double strand breaks (DSB) as well as DNA fragment distribution. The application is user friendly and can be used following simple macro commands. The results of the Monte Carlo simulation are compared to experimental data of DSB yields, as well as with previously published simulation data.

Given the well-established potential of chalcones in modulating the response of cancer cells to therapeutic interventions, coupled with the growing imperative to enhance their biological attributes, the objective of this study was to synthesize a methoxy-substituted chalcone (OCH3) and assess its capacity to amplify the inhibitory effects of radiation in melanoma cells known for their resistance to radiotherapy. The A375 melanoma cells were subjected to a clinically relevant dose of 2 Gy gamma irradiation. OCH3 was employed either as a standalone treatment or in conjunction with irradiation. The obtained results unveiled the substantial radiosensitizing potential of OCH3 within this specific cell line. Our subsequent investigations will be designed to investigate the underlying mechanisms that contribute to the radiosensitizing properties of OCH3. Moreover, we intend to evaluate the efficacy of OCH3 against other types of radioresistant cancer cells. The presented data not only illuminates the enhanced therapeutic possibilities offered by OCH3 but also highlights its potential as a valuable agent in addressing a wider array of challenging malignancies.

Abstract The CMS experiment at CERN uses a two-stage triggering system composed of the Level-1 (L1), instrumented with custom-designed hardware boards with an output rate of 100 kHz, and the High Level Trigger (HLT), streamlined version of the offline software reconstruction that runs on the computing farm, allowing to store around 1.5 kHz of rate. New trigger algorithms and new features, as well as optimized trigger menus at both L1 and HLT are mandatory in order to be able to successfully record the events at higher data loads due to increasing luminosity and pileup at the LHC in Run 3. Many measurements and searches will profit from the updates implemented in the CMS trigger. The highlights of Run 2 CMS trigger results will be presented, together with the improvements for Run 3.

The most recent results of a Higgs boson production and properties from the CMS Collaboration using the LHC Run 1 and Run 2 data are reported. These include analyses of a Higgs boson decaying to a pair of photons, four leptons via Z boson pair decays and the associated production of a Higgs boson with top quark pair, predicted by the Standard Model (SM). The studies of a Higgs boson decays to a pair of bottom quarks, a pair of tau leptons and a charm quark pair are also presented. The Higgs boson production via vector boson fusion (VBF) and decaying to invisible particles is reported here as well. The analysis of a Higgs boson decay to a pair of muons is also presented. The study of a Higgs boson pair production at 13 TeV is performed as well and projections of a Higgs boson self couplings together with the couplings to other particles at the HL-LHC are made.

A group of Early-Career Researchers (ECRs) has been given a mandate from the European Committee for Future Accelerators (ECFA) to debate the topics of the current European Strategy Update (ESU) for Particle Physics and to summarise the outcome in a brief document [1]. A full-day debate with 180 delegates was held at CERN, followed by a survey collecting quantitative input. During the debate, the ECRs discussed future colliders in terms of the physics prospects, their implications for accelerator and detector technology as well as computing and software. The discussion was organised into several topic areas. From these areas two common themes were particularly highlighted by the ECRs: sociological and human aspects; and issues of the environmental impact and sustainability of our research.

The most recent diboson production and electroweak physics results from CMS are presented. This overview is focused on the precise measurement of WW, WZ, ZZ and γγ production, as well as W or Z production in association with a photon. These results are interpreted in terms of constraints on anomalous triple gauge couplings, while the study of WWγ and WZγ production is used to set limits on anomalous quartic gauge couplings. Selection of the latest electroweak results is also presented. Presented at LaThuile 2015 XXIXth Rencontres de Physique de la Vallee dAoste IL NUOVO CIMENTO Vol. ?, N. ? ? Studies of vector boson production at CMS Milos Dordevic on behalf of the CMS Collaboration European Organization for Nuclear Research (CERN), Geneva, Switzerland Summary. — The most recent diboson production and electroweak physics results from CMS are presented. This overview is focused on the precise measurement of WW, WZ, ZZ and γγ production, as well as W or Z production in association with a photon. These results are interpreted in terms of constraints on anomalous triple gauge couplings, while the study of WWγ and WZγ production is used to set limits on anomalous quartic gauge couplings. Selection of the latest electroweak results is also presented. PACS 14.70.Fm – W bosons. PACS 14.70.Hp – Z bosons. PACS 14.70.Bh – Photons. 1. – Introduction The measurement of the diboson production and studies of the electroweak processes represent a fundamental test of the Standard Model (SM). The self-interaction between the vector bosons is precisely predicted by the SM and results from the non-Abelian nature of the SU(2)xU(1). Any difference of the measured cross section from the SM prediction, or a deviation in the kinematic distribution of the diboson pair, would indicate a presence of new physics. Therefore, such studies are an excellent probe for the possible existence of the anomalous triple and quartic gauge couplings, aTGC and aQGC. Moreover, diboson and electroweak processes are often irreducible background for Higgs boson studies and various beyond SM searches. The CMS experiment at CERN [1] has recorded data from the proton-proton collisions, delivered by the Large Hadron Collider (LHC) in 2011 and 2012 at center-of-mass energies of 7 and 8 TeV, that allowed the CMS Collaboration to measure the diboson production cross sections and study the electroweak physics at the energy scale never probed before. 2. – Measurement of ZZ production The inclusive and differential cross section of the ZZ production in the four lepton final state were measured using 19.6 fb−1 of data recorded at the energy of 8 TeV [2]. c © Societa Italiana di Fisica 1 2 MILOS DORDEVIC ON BEHALF OF THE CMS COLLABORATION The mutually exclusive sets of 4e, 4μ, 2e2μ and llττ were first studied individually and then combined using a simultaneous fit, to obtain the measured cross section of σdata = 7.7±0.5(stat.) −0.4(syst.)±0.4(th.)±0.2(lum.)pb, found to be in a good agreement with the SM prediction of 7.7±0.6pb. Both Z bosons are required to be produced within the mass window of 60 to 120 GeV. The differential cross section normalised to the fiducial cross section is shown in fig. 1. A good agreement with respect to the NLO theory prediction from MCFM 6.0 [3] was found. The measurement of the ZZ production cross section was also performed in the final state with two leptons (electrons or muons) and two neutrinos, at both 7 and 8 TeV, using 4.9 fb−1 and 19.6 fb−1, respectively [4]. This channel profits from the six times larger branching ratio than the four lepton, but is largely contaminated from the backgrounds, in particular from the Drell-Yan (DY) process. The crucial part here is the reconstruction of the missing transverse energy (MET), where the reduced-MET variable [5, 6, 7] was applied, shown to be effective in suppressing the instrumentally induced MET of the DY process. The cross section was extracted using a profile likelihood fit to the reduced MET and measured to be σdata = 5.0 +1.5 −1.4(stat.) +1.3 −1.0(syst.) ± 0.2(lumi)pb and σdata = 6.8 +0.8 −0.8(stat.) +1.8 −1.4(syst.)± 0.3(lumi)pb at 7 and 8 TeV, respectively. Results are in a good agreement with the SM prediction at NLO. The reduced MET distribution is shown in fig. 1, after the final event selection. (GeV) ZZ m 100 200 300 400 500 600 700 800 ) (1 /G eV )

Recent results of Standard Model physics using 7 and 8 TeV data recorded by the CMS detector are reviewed. This overview includes studies of vector boson production, results on V+jets production with light and heavy flavours, multiboson measurements and anomalous couplings searches and also the latest results on jet production and properties. The most recent 13 TeV results are presented as well. The outlined results are compared to the prediction of the Standard Model. Presented at ICPPA2015 International Conference on Particle Physics and Astrophysics Recent Standard Model measurements at CMS M Dordevic on behalf of the CMS Collaboration1, CERN, Route de Meyrin 385, CH-1211 Geneva 23, Switzerland E-mail: milos.dordevic@cern.ch Abstract. Recent results of Standard Model physics using 7 and 8 TeV data recorded by the CMS detector are reviewed. This overview includes studies of vector boson production, results on V+jets production with light and heavy flavours, multiboson measurements and anomalous couplings searches and also the latest results on jet production and properties. The most recent 13 TeV results are presented as well. The outlined results are compared to the prediction of the Standard Model. Recent results of Standard Model physics using 7 and 8 TeV data recorded by the CMS detector are reviewed. This overview includes studies of vector boson production, results on V+jets production with light and heavy flavours, multiboson measurements and anomalous couplings searches and also the latest results on jet production and properties. The most recent 13 TeV results are presented as well. The outlined results are compared to the prediction of the Standard Model.

Recent results of Standard Model physics using 7 and 8 TeV data recorded by the CMS detector are reviewed. This overview includes studies of vector boson production, results on V+jets production with light and heavy flavours, multiboson measurements and anomalous couplings searches and also the latest results on jet production and properties. The most recent 13 TeV results are presented as well. The outlined results are compared to the prediction of the Standard Model.

The highlights of the most recent CMS results with 13 TeV data will be presented in this overview. The Standard Model precision measurements, including the top quark production, will be shown first. This will be followed by the presentation of Higgs boson studies with the early 13 TeV data. Then the focus will shift to searches for physics beyond the Standard Model, including the searches for several Supersymmetric scenarios, using different analysis techniques. The talk will conclude with searches for the exotic resonances, with an emphasis on studies of the high-mass diphoton production.

Bez obzira na krivicno pravo koje jasno propisuje kazne za krivicna djela koja lica pocine, te zakon o izvrsenju krivicnih sankcija, koji striktno ukazuje na mjeru i nacin izdržavanja izrecene zatvorske kazne osuđena lica koja se nalaze na izdržavanju kazne imaju svoja pravila i svoj nacin određivanja kazne za pojedina lica. Zatvorska zajednica je specificna subkultura koja kroz svoja nepisana zatvorska pravila (zatvorenicki kodeks) izrice pojedincima, koja su za njih pocinila nemoralna djela (polno nasilje nad djetetom, silovanje, ..) kao i lica koja su nekada bili pripadnici MUP, dodatnu kaznu. Iako su svi, koji se nalaze na izdržavanju kazne u nekoj od kazneno-popravnih ustanova izloženi brojnim deprivacijama, sloboda i određni položaj unutar ove specificne zajednice se kupuje ili stice kroz dokazivanje u neformalnoj grupi. Neformalni sistem je uvijek nasuprot onom formalnom i kao takav narusava funkcionisanje ustanove, te otežava odvijanje i samog procesa resocijalizacije. Upravo i cilj ovog rada jeste da ukažemo na karakteristike neformalnog zatvorskog sistema, te objasnimo kako i na koji nacin se sami zatvorenici stavljaju u položaj «sudije» i određuju pojedincima kaznu unutar svoje zatvorenicke zajednice.

A selection of the most recent results of Higgs boson production and properties from the CMS Collaboration using the LHC Run 2 data is reported.The studies presented include analyses of Higgs boson decaying to two photons, four leptons via Z boson pair and associated production with top quark pair, predicted within the Standard Model (SM) of particle physics.Outlined searches for physics beyond the SM are the inverted top coupling search using Higgs boson produced with single top quark, then charged Higgs boson decaying to tau and neutrino and MSSM Higgs boson decaying to tau pairs.Prospects for future searches for the SM Higgs boson at the High Luminosity LHC and upgraded CMS detector are reported at the end.

In preparation for collecting proton-proton collisions from the LHC at a center-of-mass energy of 13 TeV and rate of 40MHz with increasing instantaneous luminosity, the CMS collaboration prepared an array of triggers utilizing jets and missing transverse energy for searches for new physics at the energy frontier as well as for SM precision measurements. The CMS trigger system must be able to sift through the collision events in order to extract events of interest at a rate of 1kHz, applying sophisticated algorithms adapted for fast and effective operation. Particularly important is the calibration of the trigger objects, as corrections to the measured energy may be substantial. Equally important is the development of improved reconstruction algorithms to mitigate negative effects due to high numbers of overlapping proton-proton collisions and increased levels of beam-related effects. Work by the CMS collaboration on upgrading the high-level trigger for jets and missing transverse energy for the upgraded LHC operation will be presented, along with the improved performance of these triggers.

An overview of recent results on electroweak precision measurements from the CMS Collaboration is presented. Studies of the weak boson differential transverse momentum spectra, Z boson angular coefficients, forward-backward asymmetry of Drell-Yan lepton pairs and charge asymmetry of W boson production are made in comparison to the state-of-the-art Monte Carlo generators and theoretical predictions. The results show a good agreement with the Standard Model. As a proof of principle for future W mass measurements, a W-like analysis of the Z boson mass is performed.

Mössbauer spectra of human liver ferritin and its pharmaceutical analogues Ferrum Lek and Maltofer® measured at various temperatures within the range of 295–83 K were fitted using five quadrupole doublets related to different 57Fe microenvironments in various layers/regions of the ferrihydrite and akaganéite iron cores. The observed anomalous temperature dependences of some Mössbauer parameters were considered as a result of low temperature structural rearrangements in different layers/regions in the iron core.

First results of a search for the Standard Model Higgs boson produced in association with a top quark-antiquark pair (ttH) in proton-proton collisions at a center of mass energy of 13 TeV is presented. The decays of Higgs boson into two photons, bottom quark-antiquark pair and multileptons via WW, ZZ and tautau pairs are analysed separately and then combined. The results are presented in terms of the best-fit signal strength relative to the Standard Model prediction and the observed and expected upper limits at the 95% confidence level are extracted.

An overview of recent results on electroweak precision measurements from the CMS Collaboration is presented. Studies of the weak boson differential transverse momentum spectra, Z boson angular coefficients, forward-backward asymmetry of Drell-Yan lepton pairs and charge asymmetry of W boson production are made in comparison to the state-of-the-art Monte Carlo generators and theoretical predictions. The results show a good agreement with the Standard Model. As a proof of principle for future W mass measurements, a W-like analysis of the Z boson mass is performed.

The scientific community shows a great interest in the study of DNA damage induction, DNA damage repair and the biological effects on cells and cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far to study these mechanisms using Monte Carlo simulations. This study outlines a Geant4-DNA example application, named "molecularDNA", publicly released in the 11.1 version of Geant4 (December 2022). It was developed for novice Geant4 users and requires only a basic understanding of scripting languages to get started. The example currently proposes two different DNA-scale geometries of biological targets, namely "cylinders", and the "human cell". This public version is based on a previous prototype and includes new features such as: the adoption of a new approach for the modeling of the chemical stage (IRT-sync), the use of the Standard DNA Damage (SDD) format to describe radiation-induced DNA damage and upgraded computational tools to estimate DNA damage response. Simulation data in terms of single strand break (SSB) and double strand break (DSB) yields were produced using each of these geometries. The results were compared to the literature, to validate the example, producing less than 5 % difference in all cases.

Analiza umetnickog dela kao govora u govoru i kompleksa vrednosti pocinje procesom prevođenja kriticarevog saznanja u razumevanje teksta. Otvoricemo problem svesti o delu pisca i junaka kao jednu dimenziju dela na primeru dve pripovetke Đure Jaksica. Da bi se prosirilo i produbilo interesovanje za jednog pisca proslosti, nužno je kriticko osavremenjavanje. Jedna noc i Komadic svajcarskog sira su stilski primeri vrednosti nasega pisca.

The event reconstruction at the Compact Muon Solenoid (CMS) experiment at the CERN Large Hadron Collider (LHC) is predominantly based on the Particle Flow algorithm. This algorithm for a global event description uses the information from all subdetector systems, unlike the previous, traditional approaches that were focused on the localized information in each subdetector. These traditional methods use the raw information (tracks, hits), while the Particle Flow algorithm completely reconstructs the event by identifying and reconstructing the comprehensive list of final-state particles (photons, electrons, muons, charged and neutral hadrons), resulting in superior reconstruction of jets, missing transverse energy, tau leptons, electrons and muons. This approach also allows for efficient identification and mitigation of the pileup effect. The concept and performance of the Particle Flow algorithm, together with the prospects for its development in the context of the upgraded CMS detector, are presented in this overview.

Jets are the experimental signatures of energetic quarks and gluons produced in high energy processes and they need to be calibrated in order to have the correct energy scale. A detailed understanding of both the energy scale and the transverse momentum resolution of jets at the CMS experiment is of crucial importance for many physics analyses. In this talk, we present the measurements of the CMS jet energy scale and resolution using the data sample collected in proton-proton collisions at a center-of-mass energy of 13 TeV.

The LHC results on the sub-leading flow modes in PbPb collisions at 2.76 TeV, related to initial-state fluctuations, are analyzed and interpreted within the HYDJET++ model. Using the newly introduced Principal Component Analysis (PCA) method applied to two-particle azimuthal correlations extracted from the model calculations, the leading and the sub-leading flow modes are studied as a function of the transverse momentum (pT ) over a wide centrality range. The leading modes of the elliptic (v (1) 2 ) and triangular (v 3 (1) 3) flow calculated within the HYDJET++ model reproduce rather well the v 2 {2} and v 3 {2} coeffcients experimentally measured using the two-particle correlations. Within the pT ≤3 GeV/c range where hydrodynamics dominates, the sub-leading flow effects are greatest at the highest pT of around 3 GeV/c. The sub-leading elliptic flow mode (v 2 (2) ), which corresponds to n=2 harmonic, has a small non-zero value and slowly increases from central to peripheral collisions, while the sub-leading triangular flow mode (v 3 (2) ), which corresponds to n =3 harmonic, is even smaller and does not depend on centrality. For n =2, the relative magnitude of the effect measured with respect to the leading flow mode shows a shallow minimum for semi-central collisions and increases for very central and for peripheral collisions. For n =3 case, there is no centrality dependence. The subleading flow mode results obtained from the HYDJET++ model are in a rather good agreement with the experimental measurements of the CMS Collaboration.

Addition of different amounts of Cu and Ag to Au alloys, as well as some new elements (Zn and Cd), gives alloys of the different colour spectrum (from red to yellow) and different technological and metallurgical characteristics.The trend today is the implementation of new alloys not containing Ag, and including new elements, such as Ga and In.Differences in two Au alloys exist: the first alloy contains Ni and Pd, and the second alloy is without them.The values of electrical conductivity and hardness are different, due to the reduction, which was shown using PCA (r=0.985 and the strong positive correlation between hardness and electrical conductivity).Performed tests confirm that those multiphase multi component gold alloys can find their application not only in jewellery making but also in the world of modern electrical engineering.The performed statistical analysis shows strong positive and negative correlations of properties of investigated Au alloys, and it provides significant savings in the design and efficiency of metallurgical processes.

The performance of jet and missing transverse energy (MET) reconstruction at the CMS experiment in LHC Run 2 data will be shown.The efficiencies of the reconstruction at the High Level Trigger will be discussed first, followed by the performance of the pileup mitigation techniques used in the jet and MET selection.The jet energy scale corrections used at the CMS experiment will be described, as well as the MET cleaning and reconstruction performance.The conclusions will be outlined with respect to the performance of jet and MET objects, with prospects for future studies.

A selection of the most recent results from the CMS Collaboration at CERN is presented in this overview.The CMS detector status and performance in the LHC Run 2 are outlined.The results of Standard Model physics studies, the studies of the Higgs boson production and properties, as well as a selection of the results of beyond Standard Model searches and an observation of a new excited beauty baryon are presented and discussed.All the results outlined in this overview are found to be in a good agreement with the Standard Model of particle physics.The activities of the CMS Collaboration during the Long Shutdown 2, status and plans for the incoming LHC Run 3, as well as preparation for the HL-LHC are also presented.