Leszek Grzanka

TOTEM has measured the differential cross-section for elastic proton-proton scattering at the LHC energy of analysing data from a short run with dedicated large-β* optics. A single exponential fit with a slope B=(20.1±0.2stat±0.3syst) GeV−2 describes the range of the four-momentum transfer squared |t| from 0.02 to 0.33 GeV2. After the extrapolation to |t|=0, a total elastic scattering cross-section of (24.8±0.2stat±1.2syst) mb was obtained. Applying the optical theorem and using the luminosity measurement from CMS, a total proton-proton cross-section of (98.3±0.2stat±2.8syst) mb was deduced which is in good agreement with the expectation from the overall fit of previously measured data over a large range of center-of-mass energies. From the total and elastic pp cross-section measurements, an inelastic pp cross-section of was inferred.

At the LHC energy of , under various beam and background conditions, luminosities, and Roman Pot positions, TOTEM has measured the differential cross-section for proton-proton elastic scattering as a function of the four-momentum transfer squared t. The results of the different analyses are in excellent agreement demonstrating no sizeable dependence on the beam conditions. Due to the very close approach of the Roman Pot detectors to the beam center (≈5σbeam) in a dedicated run with β* = 90 m, |t|-values down to 5·10−3 GeV2 were reached. The exponential slope of the differential elastic cross-section in this newly explored |t|-region remained unchanged and thus an exponential fit with only one constant B = (19.9 ± 0.3) GeV−2 over the large |t|-range from 0.005 to 0.2 GeV2 describes the differential distribution well. The high precision of the measurement and the large fit range lead to an error on the slope parameter B which is remarkably small compared to previous experiments. It allows a precise extrapolation over the non-visible cross-section (only 9%) to t = 0. With the luminosity from CMS, the elastic cross-section was determined to be (25.4 ± 1.1) mb, and using in addition the optical theorem, the total pp cross-section was derived to be (98.6 ± 2.2) mb. For model comparisons the t-distributions are tabulated including the large |t|-range of the previous measurement (TOTEM Collaboration (Antchev G. et al), EPL, 95 (2011) 41001).

The TOTEM collaboration has measured the proton-proton total cross section at √s=8 TeV using a luminosity-independent method. In LHC fills with dedicated beam optics, the Roman pots have been inserted very close to the beam allowing the detection of ~90% of the nuclear elastic scattering events. Simultaneously the inelastic scattering rate has been measured by the T1 and T2 telescopes. By applying the optical theorem, the total proton-proton cross section of (101.7±2.9) mb has been determined, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: σ(el)=(27.1±1.4) mb; σ(inel)=(74.7±1.7) mb.

The TOTEM experiment at the LHC has performed the first luminosity-independent determination of the total proton-proton cross-section at . This technique is based on the optical theorem and requires simultaneous measurements of the inelastic rate – accomplished with the forward charged-particle telescopes T1 and T2 in the range 3.1 < |η| < 6.5 – and of the elastic rate by detecting the outcoming protons with Roman Pot detectors. The data presented here were collected in a dedicated run in 2011 with special beam optics (β* = 90 m) and Roman Pots approaching the beam close enough to register elastic events with squared four-momentum transfers |t| as low as 5·10−3 GeV2. The luminosity-independent results for the elastic, inelastic and total cross-sections are σel = (25.1 ± 1.1) mb, σinel = (72.9 ± 1.5) mb and σtot = (98.0 ± 2.5) mb, respectively. At the same time this method yields the integrated luminosity, in agreement with measurements by CMS. TOTEM has also determined the total cross-section in two complementary ways, both using the CMS luminosity measurement as an input. The first method sums the elastic and inelastic cross-sections and thus does not depend on the ρ parameter. The second applies the optical theorem to the elastic-scattering measurements only and therefore is free of the T1 and T2 measurement uncertainties. The methods, having very different systematic dependences, give results in excellent agreement. Moreover, the ρ-independent measurement makes a first estimate for the ρ parameter at possible: |ρ| = 0.145 ± 0.091.

The TOTEM experiment has made a precise measurement of the elastic proton–proton differential cross-section at the centre-of-mass energy s=8TeV based on a high-statistics data sample obtained with the β⁎=90m optics. Both the statistical and systematic uncertainties remain below 1%, except for the t-independent contribution from the overall normalisation. This unprecedented precision allows to exclude a purely exponential differential cross-section in the range of four-momentum transfer squared 0.027<|t|<0.2GeV2 with a significance greater than 7σ. Two extended parametrisations, with quadratic and cubic polynomials in the exponent, are shown to be well compatible with the data. Using them for the differential cross-section extrapolation to t=0, and further applying the optical theorem, yields total cross-section estimates of (101.5±2.1)mb and (101.9±2.1)mb, respectively, in agreement with previous TOTEM measurements.

Proton-proton elastic scattering has been measured by the TOTEM experiment at the CERN Large Hadron Collider at in dedicated runs with the Roman Pot detectors placed as close as seven times the transverse beam size (σbeam) from the outgoing beams. After careful study of the accelerator optics and the detector alignment, |t|, the square of four-momentum transferred in the elastic scattering process, has been determined with an uncertainty of . In this letter, first results of the differential cross-section are presented covering a |t|-range from 0.36 to 2.5 GeV2. The differential cross-section in the range 0.36 < |t| < 0.47 GeV2 is described by an exponential with a slope parameter B = (23.6 ± 0.5stat ± 0.4syst) GeV−2, followed by a significant diffractive minimum at |t| = (0.53 ± 0.01stat ± 0.01syst) GeV2. For |t|-values larger than ∼1.5 GeV2, the cross-section exhibits a power law behaviour with an exponent of −7.8 ± 0.3stat ± 0.1syst. When compared to predictions based on the different available models, the data show a strong discriminative power despite the small t-range covered.

The TOTEM experiment at the CERN LHC has measured elastic proton–proton scattering at the centre-of-mass energy $$\sqrt{s}=8\,$$ TeV and four-momentum transfers squared, |t|, from $$6\times 10^{-4}$$ to 0.2 GeV $$^{2}$$ . Near the lower end of the t-interval the differential cross-section is sensitive to the interference between the hadronic and the electromagnetic scattering amplitudes. This article presents the elastic cross-section measurement and the constraints it imposes on the functional forms of the modulus and phase of the hadronic elastic amplitude. The data exclude the traditional Simplified West and Yennie interference formula that requires a constant phase and a purely exponential modulus of the hadronic amplitude. For parametrisations of the hadronic modulus with second- or third-order polynomials in the exponent, the data are compatible with hadronic phase functions giving either central or peripheral behaviour in the impact parameter picture of elastic scattering. In both cases, the $$\rho $$ -parameter is found to be $$0.12 \pm 0.03$$ . The results for the total hadronic cross-section are $$\sigma _\mathrm{tot} = (102.9 \pm 2.3)$$ mb and $$(103.0 \pm 2.3)$$ mb for central and peripheral phase formulations, respectively. Both are consistent with previous TOTEM measurements.

The TOTEM collaboration has measured the proton–proton total cross section at $$\sqrt{s}=13~\hbox {TeV}$$ with a luminosity-independent method. Using dedicated $$\beta ^{*}=90~\hbox {m}$$ beam optics, the Roman Pots were inserted very close to the beam. The inelastic scattering rate has been measured by the T1 and T2 telescopes during the same LHC fill. After applying the optical theorem the total proton–proton cross section is $$\sigma _\mathrm{tot}=(110.6~\pm ~3.4$$ ) mb, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: $$\sigma _\mathrm{el}=(31.0~\pm ~1.7)~\hbox {mb}$$ and $$\sigma _\mathrm{inel}=(79.5~\pm ~1.8)~\hbox {mb}$$ .

Abstract The TOTEM experiment at the LHC has performed the first measurement at $$\sqrt{s} = 13\,\mathrm{TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn><mml:mspace /><mml:mi>TeV</mml:mi></mml:mrow></mml:math> of the $$\rho $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ρ</mml:mi></mml:math> parameter, the real to imaginary ratio of the nuclear elastic scattering amplitude at $$t=0$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>t</mml:mi><mml:mo>=</mml:mo><mml:mn>0</mml:mn></mml:mrow></mml:math> , obtaining the following results: $$\rho = 0.09 \pm 0.01$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>ρ</mml:mi><mml:mo>=</mml:mo><mml:mn>0.09</mml:mn><mml:mo>±</mml:mo><mml:mn>0.01</mml:mn></mml:mrow></mml:math> and $$\rho = 0.10 \pm 0.01$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>ρ</mml:mi><mml:mo>=</mml:mo><mml:mn>0.10</mml:mn><mml:mo>±</mml:mo><mml:mn>0.01</mml:mn></mml:mrow></mml:math> , depending on different physics assumptions and mathematical modelling. The unprecedented precision of the $$\rho $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ρ</mml:mi></mml:math> measurement, combined with the TOTEM total cross-section measurements in an energy range larger than $$10\,\mathrm{TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>10</mml:mn><mml:mspace /><mml:mi>TeV</mml:mi></mml:mrow></mml:math> (from 2.76 to $$13\,\mathrm{TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>13</mml:mn><mml:mspace /><mml:mi>TeV</mml:mi></mml:mrow></mml:math> ), has implied the exclusion of all the models classified and published by COMPETE. The $$\rho $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ρ</mml:mi></mml:math> results obtained by TOTEM are compatible with the predictions, from other theoretical models both in the Regge-like framework and in the QCD framework, of a crossing-odd colourless 3-gluon compound state exchange in the t -channel of the proton–proton elastic scattering. On the contrary, if shown that the crossing-odd 3-gluon compound state t -channel exchange is not of importance for the description of elastic scattering, the $$\rho $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ρ</mml:mi></mml:math> value determined by TOTEM would represent a first evidence of a slowing down of the total cross-section growth at higher energies. The very low-| t | reach allowed also to determine the absolute normalisation using the Coulomb amplitude for the first time at the LHC and obtain a new total proton–proton cross-section measurement $$\sigma _{\mathrm{tot}} = (110.3 \pm 3.5)\,\mathrm{mb}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mi>σ</mml:mi><mml:mi>tot</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mrow><mml:mo>(</mml:mo><mml:mn>110.3</mml:mn><mml:mo>±</mml:mo><mml:mn>3.5</mml:mn><mml:mo>)</mml:mo></mml:mrow><mml:mspace /><mml:mi>mb</mml:mi></mml:mrow></mml:math> , completely independent from the previous TOTEM determination. Combining the two TOTEM results yields $$\sigma _{\mathrm{tot}} = (110.5 \pm 2.4)\,\mathrm{mb}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mi>σ</mml:mi><mml:mi>tot</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mrow><mml:mo>(</mml:mo><mml:mn>110.5</mml:mn><mml:mo>±</mml:mo><mml:mn>2.4</mml:mn><mml:mo>)</mml:mo></mml:mrow><mml:mspace /><mml:mi>mb</mml:mi></mml:mrow></mml:math> .

Linear Energy Transfer (LET) is widely used to express the radiation quality of ion beams, when characterizing the biological effectiveness. However, averaged LET may be defined in multiple ways, and the chosen definition may impact the resulting reported value. We review averaged LET definitions found in the literature, and quantify which impact using these various definitions have for different reference setups. We recorded the averaged LET definitions used in 354 publications quantifying the relative biological effectiveness (RBE) of hadronic beams, and investigated how these various definitions impact the reported averaged LET using a Monte Carlo particle transport code. We find that the kind of averaged LET being applied is, generally, poorly defined. Some definitions of averaged LET may influence the reported averaged LET values up to an order of magnitude. For publications involving protons, most applied dose averaged LET when reporting RBE. The absence of what target medium is used and what secondary particles are included further contributes to an ill-defined averaged LET. We also found evidence of inconsistent usage of averaged LET definitions when deriving LET-based RBE models. To conclude, due to commonly ill-defined averaged LET and to the inherent problems of LET-based RBE models, averaged LET may only be used as a coarse indicator of radiation quality. We propose a more rigorous way of reporting LET values, and suggest that ideally the entire particle fluence spectra should be recorded and provided for future RBE studies, from which any type of averaged LET (or other quantities) may be inferred.

The TOTEM experiment at the LHC has measured the inelastic proton-proton cross-section at in a β* = 90 m run with low inelastic pile-up. The measurement was based on events with at least one charged particle in the T2 telescope acceptance of 5.3 < |η| < 6.5 in pseudorapidity. Combined with data from the T1 telescope, covering 3.1 < |η| < 4.7, the cross-section for inelastic events with at least one |η| ⩽ 6.5 final-state particle was determined to be (70.5 ± 2.9) mb. This cross-section includes all central diffractive events of which maximally 0.25 mb is estimated to escape the detection of the telescopes. Based on models for low mass diffraction, the total inelastic cross-section was deduced to be (73.7 ± 3.4) mb. An upper limit of 6.31 mb at 95% confidence level on the cross-section for events with diffractive masses below 3.4 GeV was obtained from the difference between the overall inelastic cross-section obtained by TOTEM using elastic scattering and the cross-section for inelastic events with at least one |η| ⩽ 6.5 final-state particle.

The aim of the present study was to examine the RBE for early damage in an in vivo mouse model, and the effect of the increased linear energy transfer (LET) towards the distal edge of the spread-out Bragg peak (SOBP).The lower part of the right hind limb of CDF1 mice was irradiated with single fractions of either 6 MV photons, 240 kV photons or scanning beam protons and graded doses were applied. For the proton irradiation, the leg was either placed in the middle of a 30-mm SOBP, or to assess the effect in different positions, irradiated in 4 mm intervals from the middle of the SOBP to behind the distal dose fall-off. Irradiations were performed with the same dose plan at all positions, corresponding to a dose of 31.25 Gy in the middle of the SOBP. Endpoint of the study was early skin damage of the foot, assessed by a mouse foot skin scoring system.The MDD50 values with 95% confidence intervals were 36.1 (34.2-38.1) Gy for protons in the middle of the SOBP for score 3.5. For 6 MV photons, it was 35.9 (34.5-37.5) Gy and 32.6 (30.7-34.7) Gy for 240 kV photons for score 3.5. The corresponding RBE was 1.00 (0.94-1.05), relative to 6 MV photons and 0.9 (0.85-0.97) relative to 240 kV photons. In the mice group positioned at the SOBP distal dose fall-off, 25% of the mice developed early skin damage compared with 0-8% in other groups. LETd,z = 1 was 8.4 keV/μm at the distal dose fall-off and the physical dose delivered was 7% lower than in the central SOBP position, where LETd,z =1 was 3.3 keV/μm.Although there is a need to expand the current study to be able to calculate an exact enhancement ratio, an enhanced biological effect in vivo for early skin damage in the distal edge was demonstrated.

Abstract The TOTEM collaboration has measured the elastic proton-proton differential cross section $$\mathrm{d}\sigma /\mathrm{d}t$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>d</mml:mi><mml:mi>σ</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:math> at $$\sqrt{s}=13$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:mrow></mml:math> TeV LHC energy using dedicated $$\beta ^{*}=90$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>β</mml:mi><mml:mrow><mml:mrow /><mml:mo>∗</mml:mo></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>90</mml:mn></mml:mrow></mml:math> m beam optics. The Roman Pot detectors were inserted to 10 $$\sigma $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>σ</mml:mi></mml:math> distance from the LHC beam, which allowed the measurement of the range [0.04 GeV $$^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mn>2</mml:mn></mml:msup></mml:math> ; 4 GeV $$^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mn>2</mml:mn></mml:msup></mml:math> $$]$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mo>]</mml:mo></mml:math> in four-momentum transfer squared | t |. The efficient data acquisition allowed to collect about 10 $$^{9}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mn>9</mml:mn></mml:msup></mml:math> elastic events to precisely measure the differential cross-section including the diffractive minimum (dip), the subsequent maximum (bump) and the large-| t | tail. The average nuclear slope has been found to be $$B=(20.40 \pm 0.002^{\mathrm{stat}} \pm 0.01^{\mathrm{syst}})~$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>B</mml:mi><mml:mo>=</mml:mo><mml:mo>(</mml:mo><mml:mn>20.40</mml:mn><mml:mo>±</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:msup><mml:mn>002</mml:mn><mml:mi>stat</mml:mi></mml:msup><mml:mo>±</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:msup><mml:mn>01</mml:mn><mml:mi>syst</mml:mi></mml:msup><mml:mo>)</mml:mo><mml:mspace /></mml:mrow></mml:math> GeV $$^{-2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mrow><mml:mo>-</mml:mo><mml:mn>2</mml:mn></mml:mrow></mml:msup></mml:math> in the | t |-range 0.04–0.2 GeV $$^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mn>2</mml:mn></mml:msup></mml:math> . The dip position is $$|t_{\mathrm{dip}}|=(0.47 \pm 0.004^{\mathrm{stat}} \pm 0.01^{\mathrm{syst}})~$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mrow><mml:mo>|</mml:mo></mml:mrow><mml:msub><mml:mi>t</mml:mi><mml:mi>dip</mml:mi></mml:msub><mml:mrow><mml:mo>|</mml:mo><mml:mo>=</mml:mo></mml:mrow><mml:mrow><mml:mo>(</mml:mo><mml:mn>0.47</mml:mn><mml:mo>±</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:msup><mml:mn>004</mml:mn><mml:mi>stat</mml:mi></mml:msup><mml:mo>±</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:msup><mml:mn>01</mml:mn><mml:mi>syst</mml:mi></mml:msup><mml:mo>)</mml:mo></mml:mrow><mml:mspace /></mml:mrow></mml:math> GeV $$^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mrow /><mml:mn>2</mml:mn></mml:msup></mml:math> . The differential cross section ratio at the bump vs. at the dip $$R=1.77\pm 0.01^{\mathrm{stat}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>R</mml:mi><mml:mo>=</mml:mo><mml:mn>1.77</mml:mn><mml:mo>±</mml:mo><mml:mn>0</mml:mn><mml:mo>.</mml:mo><mml:msup><mml:mn>01</mml:mn><mml:mi>stat</mml:mi></mml:msup></mml:mrow></mml:math> has been measured with high precision. The series of TOTEM elastic pp measurements show that the dip is a permanent feature of the pp differential cross-section at the TeV scale.

Abstract The proton–proton elastic differential cross section $${\mathrm{d}}\sigma /{\mathrm{d}}t$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>d</mml:mi><mml:mi>σ</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:math> has been measured by the TOTEM experiment at $$\sqrt{s}=2.76\hbox { TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>2.76</mml:mn><mml:mspace /><mml:mtext>TeV</mml:mtext></mml:mrow></mml:math> energy with $$\beta ^{*}=11\hbox { m}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mi>β</mml:mi><mml:mrow><mml:mrow /><mml:mo>∗</mml:mo></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>11</mml:mn><mml:mspace /><mml:mtext>m</mml:mtext></mml:mrow></mml:math> beam optics. The Roman Pots were inserted to 13 times the transverse beam size from the beam, which allowed to measure the differential cross-section of elastic scattering in a range of the squared four-momentum transfer (| t |) from 0.36 to $$0.74\hbox { GeV}^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>0.74</mml:mn><mml:mspace /><mml:msup><mml:mtext>GeV</mml:mtext><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math> . The differential cross-section can be described with an exponential in the | t |-range between 0.36 and $$0.54\hbox { GeV}^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>0.54</mml:mn><mml:mspace /><mml:msup><mml:mtext>GeV</mml:mtext><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math> , followed by a diffractive minimum (dip) at $$|t_{\mathrm{dip}}|=(0.61\pm 0.03)\hbox { GeV}^{2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mrow><mml:mo>|</mml:mo></mml:mrow><mml:msub><mml:mi>t</mml:mi><mml:mi>dip</mml:mi></mml:msub><mml:mrow><mml:mo>|</mml:mo><mml:mo>=</mml:mo><mml:mrow><mml:mo>(</mml:mo><mml:mn>0.61</mml:mn><mml:mo>±</mml:mo><mml:mn>0.03</mml:mn><mml:mo>)</mml:mo></mml:mrow><mml:mspace /></mml:mrow><mml:msup><mml:mtext>GeV</mml:mtext><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math> and a subsequent maximum (bump). The ratio of the $${\mathrm{d}}\sigma /{\mathrm{d}}t$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>d</mml:mi><mml:mi>σ</mml:mi><mml:mo>/</mml:mo><mml:mi>d</mml:mi><mml:mi>t</mml:mi></mml:mrow></mml:math> at the bump and at the dip is $$1.7\pm 0.2$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>1.7</mml:mn><mml:mo>±</mml:mo><mml:mn>0.2</mml:mn></mml:mrow></mml:math> . When compared to the proton–antiproton measurement of the D0 experiment at $$\sqrt{s} = 1.96\hbox { TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>1.96</mml:mn><mml:mspace /><mml:mtext>TeV</mml:mtext></mml:mrow></mml:math> , a significant difference can be observed. Under the condition that the effects due to the energy difference between TOTEM and D0 can be neglected, the result provides evidence for the exchange of a colourless C-odd three-gluon compound state in the t -channel of the proton–proton and proton–antiproton elastic scattering.

The first double diffractive cross-section measurement in the very forward region has been carried out by the TOTEM experiment at the LHC with center-of-mass energy of sqrt(s)=7 TeV. By utilizing the very forward TOTEM tracking detectors T1 and T2, which extend up to |eta|=6.5, a clean sample of double diffractive pp events was extracted. From these events, we measured the cross-section sigma_DD =(116 +- 25) mub for events where both diffractive systems have 4.7 <|eta|_min < 6.5 .

Clinical data suggest that the relative biological effectiveness (RBE) in proton therapy (PT) varies with linear energy transfer (LET). However, LET calculations are neither standardized nor available in clinical routine. Here, the status of LET calculations among European PT institutions and their comparability are assessed.Eight European PT institutions used suitable treatment planning systems with their center-specific beam model to create treatment plans in a water phantom covering different field arrangements and fulfilling commonly agreed dose objectives. They employed their locally established LET simulation environments and procedures to determine the corresponding LET distributions. Dose distributions D1.1 and DRBE assuming constant and variable RBE, respectively, and LET were compared among the institutions. Inter-center variability was assessed based on dose- and LET-volume-histogram parameters.Treatment plans from six institutions fulfilled all clinical goals and were eligible for common analysis. D1.1 distributions in the target volume were comparable among PT institutions. However, corresponding LET values varied substantially between institutions for all field arrangements, primarily due to differences in LET averaging technique and considered secondary particle spectra. Consequently, DRBE using non-harmonized LET calculations increased inter-center dose variations substantially compared to D1.1 and significantly in mean dose to the target volume of perpendicular and opposing field arrangements (p < 0.05). Harmonizing LET reporting (dose-averaging, all protons, LET to water or to unit density tissue) reduced the inter-center variability in LET to the order of 10-15% within and outside the target volume for all beam arrangements. Consequentially, inter-institutional variability in DRBE decreased to that observed for D1.1.Harmonizing the reported LET among PT centers is feasible and allows for consistent multi-centric analysis and reporting of tumor control and toxicity in view of a variable RBE. It may serve as basis for harmonized variable RBE dose prescription in PT.

In the Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Science in Krakow (IFJ PAN), Poland, in cooperation with the Department of Ophthalmology and Ophthalmic Oncology of the Collegium Medicum, Jagiellonian University and the Centre of Oncology of the Maria Skłodowska-Curie Memorial Institute Krakow Branch, is running the project of designing and operating a proton ocular radiotherapy facility in which the 60 MeV proton beam accelerated in the AIC-144 isochronous cyclotron of IFJ PAN is applied. The facility will be able to satisfy national needs of ocular melanoma therapy in Poland (about 100 cases per year).

The TOTEM experiment has measured the charged-particle pseudorapidity density dNch/dη in pp collisions at for 5.3<|η|<6.4 in events with at least one charged particle with transverse momentum above 40 MeV/c in this pseudorapidity range. This extends the analogous measurement performed by the other LHC experiments to the previously unexplored forward η region. The measurement refers to more than 99% of non-diffractive processes and to single and double diffractive processes with diffractive masses above ∼3.4 GeV/c2, corresponding to about 95% of the total inelastic cross-section. The dNch/dη has been found to decrease with |η|, from 3.84 ± 0.01(stat) ± 0.37(syst) at |η|=5.375 to 2.38±0.01(stat)±0.21(syst) at |η|=6.375. Several MC generators have been compared to data; none of them has been found to fully describe the measurement.

We present an open-source code library for amorphous track modelling which is suppose to faciliate the application and numerical comparability as well as serve as a frame-work for the implementation of new models. We show an example of using the library indicating the choice of submodels has a significant impact on the modelling outcome.

Proton-proton elastic scattering has been measured by the TOTEM experiment at the CERN Large Hadron Collider at √s = 7 TeV in special runs with the Roman Pot detectors placed as close to the outgoing beam as seven times the transverse beam size. The differential cross-section measurements are reported in the |t|-range of 0.36 to 2.5 GeV2. Extending the range of data to low t values from 0.02 to 0.33 GeV2, and utilizing the luminosity measurements of CMS, the total proton-proton cross section at √s = 7 TeV is measured to be (98.3 ±0.2stat ±2.8syst) mb.

The TOTEM Experiment is designed to measure the total proton-proton cross-section with the luminosity-independent method and to study elastic and diffractive pp scattering at the LHC. To achieve optimum forward coverage for charged particles emitted by the pp collisions in the interaction point IP5, two tracking telescopes, T1 and T2, are installed on each side of the IP in the pseudorapidity region 3.1 < = |eta | < = 6.5, and special movable beam-pipe insertions - called Roman Pots (RP) - are placed at distances of +- 147 m and +- 220 m from IP5. This article describes in detail the working of the TOTEM detector to produce physics results in the first three years of operation and data taking at the LHC.

This paper describes the design and the performance of the timing detector developed by the TOTEM Collaboration for the Roman Pots (RPs) to measure the Time-Of-Flight (TOF) of the protons produced in central diffractive interactions at the LHC . The measurement of the TOF of the protons allows the determination of the longitudinal position of the proton interaction vertex and its association with one of the vertices reconstructed by the CMS detectors. The TOF detector is based on single crystal Chemical Vapor Deposition (scCVD) diamond plates and is designed to measure the protons TOF with about 50 ps time precision. This upgrade to the TOTEM apparatus will be used in the LHC run 2 and will tag the central diffractive events up to an interaction pileup of about 1. A dedicated fast and low noise electronics for the signal amplification has been developed. The digitization of the diamond signal is performed by sampling the waveform. After introducing the physics studies that will most profit from the addition of these new detectors, we discuss in detail the optimization and the performance of the first TOF detector installed in the LHC in November 2015.

<h2>Abstract</h2> Joseph the MoUSE — Mouse Ultrasonic Sound Explorer (MoUSE) software aims to address the issue of manual analysis of recordings from experiments on rodents by introducing automatic techniques for ultrasonic vocalization (USV) detection. It combines deep learning (DL) methods with classical pattern recognition and computer graphics algorithms. During development, we used a dataset that consisted of recordings from real-world experiments in the open field. Recordings like these pose obstacles to automatic USV detection, one of which is the noise produced by mice in the experimental area or in nearby cages. Therefore, additionally, we conducted research and implemented de-noising methods along with detection algorithms. The project includes Python packages with algorithms for sound noise removal and USV detection, and provides a user-friendly graphical interface.

Introduction: Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy transfer (LET) along the proton track increases the relative biological effectiveness (RBE) near the distal edge of the Spread-out Bragg peak (SOBP). The severity of normal tissue side effects following photon beam radiotherapy vary considerably between patients.Aim: The dual study aim was to identify gene expression patterns specific to radiation type and proton beam position, and to assess whether individual radiation sensitivity influences gene expression levels in fibroblast cultures irradiated in vitro.Methods: The study includes 30 primary fibroblast cell cultures from patients previously classified as either radiosensitive or radioresistant. Cells were irradiated at three different positions in the proton beam profile: entrance, mid-SOBP and at the SOBP distal edge. Dose was delivered in three fractions × 3.5 Gy(RBE) (RBE 1.1). Cobalt-60 (Co-60) irradiation was used as reference. Real-time qPCR was performed to determine gene expression levels for 17 genes associated with inflammation response, fibrosis and angiogenesis.Results: Differences in median gene expression levels were observed for multiple genes such as IL6, IL8 and CXCL12. Median IL6 expression was 30%, 24% and 47% lower in entrance, mid-SOBP and SOBP distal edge groups than in Co-60 irradiated cells. No genes were found to be oppositely regulated by different radiation qualities. Radiosensitive patient samples had the strongest regulation of gene expression; irrespective of radiation type.Conclusions: Our findings indicate that the increased LET at the SOBP distal edge position did not generally lead to increased transcriptive response in primary fibroblast cultures. Inflammatory factors were generally less extensively upregulated by proton irradiation compared with Co-60 photon irradiation. These effects may possibly influence the development of normal tissue damage in patients treated with proton beam therapy.

The pseudorapidity density of charged particles dN $$_{ ch }$$ /d $$\eta $$ is measured by the TOTEM experiment in proton–proton collisions at $$\sqrt{s} = 8$$ TeV within the range $$3.9<\eta <4.7$$ and $$-6.95<\eta <-6.9$$ . Data were collected in a low intensity LHC run with collisions occurring at a distance of 11.25 m from the nominal interaction point. The data sample is expected to include 96–97 % of the inelastic proton–proton interactions. The measurement reported here considers charged particles with $$p_T>0$$ MeV/c, produced in inelastic interactions with at least one charged particle in $$-7<\eta <-6$$ or $$3.7<\eta <4.8$$ . The dN $$_{ ch }$$ /d $$\eta $$ has been found to decrease with $$|\eta |$$ , from 5.11 $$\pm $$ 0.73 at $$\eta =3.95$$ to 1.81 $$\pm $$ 0.56 at $$\eta =-$$ 6.925. Several Monte Carlo generators are compared to the data and are found to be within the systematic uncertainty of the measurement.

(2020). Proton scanning and X-ray beam irradiation induce distinct regulation of inflammatory cytokines in a preclinical mouse model. International Journal of Radiation Biology: Vol. 96, No. 10, pp. 1238-1244.

Modern radiotherapy (RT) techniques, such as proton therapy, require more and more sophisticated dosimetry methods and materials. One of the newly developed technologies is based on flexible sheets made of a polymer, with the embedded optically stimulated luminescence (OSL) material in the form of powder (LiMgPO4, LMP) and a self-developed optical imaging setup. The detector properties were evaluated to study its potential application in the proton treatment plan verification for eyeball cancer. The data showed a well-known effect of lower luminescent efficiency of the LMP material response to proton energy. The efficiency parameter depends on a given material and radiation quality parameters. Therefore, the detailed knowledge of material efficiency is crucial in establishing a calibration method for detectors exposed to mixed radiation fields. Thus, in the present study, the prototype of the LMP-based silicone foil material was tested with monoenergetic uniform proton beams of various initial kinetic energies constituting the so-called spread-out Bragg peak (SOBP). The irradiation geometry was also modelled using the Monte Carlo particle transport codes. Several beam quality parameters, including dose and the kinetic energy spectrum, were scored. Finally, the obtained results were used to correct the relative luminescence efficiency response of the LMP foils for monoenergetic and spread-out proton beams.

Measurements from particle timing detectors are often affected by the time walk effect caused by statistical fluctuations in the charge deposited by passing particles. The constant fraction discriminator (CFD) algorithm is frequently used to mitigate this effect both in test setups and in running experiments, such as the CMS-PPS system at the CERN’s LHC. The CFD is simple and effective but does not leverage all voltage samples in a time series. Its performance could be enhanced with deep neural networks, which are commonly used for time series analysis, including computing the particle arrival time. We evaluated various neural network architectures using data acquired at the test beam facility in the DESY-II synchrotron, where a precise MCP (MicroChannel Plate) detector was installed in addition to PPS diamond timing detectors. MCP measurements were used as a reference to train the networks and compare the results with the standard CFD method. Ultimately, we improved the timing precision by 8% to 23%, depending on the detector's readout channel. The best results were obtained using a UNet-based model, which outperformed classical convolutional networks and the multilayer perceptron.

Precise knowledge of the beam optics at the LHC is crucial to fulfil the physics goals of the TOTEM experiment, where the kinematics of the scattered protons is reconstructed with the near-beam telescopes -- so-called Roman Pots (RP). Before being detected, the protons' trajectories are influenced by the magnetic fields of the accelerator lattice. Thus precise understanding of the proton transport is of key importance for the experiment. A novel method of optics evaluation is proposed which exploits kinematical distributions of elastically scattered protons observed in the RPs. Theoretical predictions, as well as Monte Carlo studies, show that the residual uncertainty of this optics estimation method is smaller than 0.25 percent.

The linear energy transfer (LET) is commonly used as a parameter which describes the quality of the radiation applied in radiation therapy with fast ions. In particular in proton therapy, most models which predict the radiobiological properties of the applied beam, are fitted to the dose-averaged LET, LETd. The related parameter called the fluence- or track-averaged LET, LETt, is less frequently used. Both LETt and in particular LETd depends profoundly on the encountered secondary particle spectrum. For proton beams including all secondary particles, LETd may reach more than 3 keV/um in the entry channel of the proton field. However, typically the charged particle spectrum is only averaged over the primary and secondary protons, which is in the order of 0.5 keV/um for the same region. This is equal to assuming that the secondary particle spectrum from heavier ions is irrelevant for the resulting radiobiology, which is an assertion in the need of closer investigation. Models which rely on LETd should also be clear on what type of LETd is used, which is not always the case. Within this work, we have extended the Monte Carlo particle transport code SHIELD-HIT12A to provide dose- and track-average LET-maps for ion radiation therapy treatment plans.

Abstract The TOTEM collaboration at the CERN LHC has measured the differential cross-section of elastic proton–proton scattering at $$\sqrt{s} = 8\,\mathrm{TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>8</mml:mn> <mml:mspace /> <mml:mi>TeV</mml:mi> </mml:mrow> </mml:math> in the squared four-momentum transfer range $$0.2\,\mathrm{GeV^{2}}&lt; |t| &lt; 1.9\,\mathrm{GeV^{2}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>0.2</mml:mn> <mml:mspace /> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> <mml:mo>&lt;</mml:mo> <mml:mrow> <mml:mo>|</mml:mo> <mml:mi>t</mml:mi> <mml:mo>|</mml:mo> </mml:mrow> <mml:mo>&lt;</mml:mo> <mml:mn>1.9</mml:mn> <mml:mspace /> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> . This interval includes the structure with a diffractive minimum (“dip”) and a secondary maximum (“bump”) that has also been observed at all other LHC energies, where measurements were made. A detailed characterisation of this structure for $$\sqrt{s} = 8\,\mathrm{TeV}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> <mml:mo>=</mml:mo> <mml:mn>8</mml:mn> <mml:mspace /> <mml:mi>TeV</mml:mi> </mml:mrow> </mml:math> yields the positions, $$|t|_{\mathrm{dip}} = (0.521 \pm 0.007)\,\mathrm{GeV^2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mrow> <mml:mo>|</mml:mo> <mml:mi>t</mml:mi> <mml:mo>|</mml:mo> </mml:mrow> <mml:mi>dip</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>0.521</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.007</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace /> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> and $$|t|_{\mathrm{bump}} = (0.695 \pm 0.026)\,\mathrm{GeV^2}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mrow> <mml:mo>|</mml:mo> <mml:mi>t</mml:mi> <mml:mo>|</mml:mo> </mml:mrow> <mml:mi>bump</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>0.695</mml:mn> <mml:mo>±</mml:mo> <mml:mn>0.026</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace /> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:math> , as well as the cross-section values, $$\left. {\mathrm{d}\sigma /\mathrm{d}t}\right| _{\mathrm{dip}} = (15.1 \pm 2.5)\,\mathrm{{\mu b/GeV^2}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mfenced> <mml:mrow> <mml:mi>d</mml:mi> <mml:mi>σ</mml:mi> <mml:mo>/</mml:mo> <mml:mi>d</mml:mi> <mml:mi>t</mml:mi> </mml:mrow> </mml:mfenced> <mml:mi>dip</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>15.1</mml:mn> <mml:mo>±</mml:mo> <mml:mn>2.5</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace /> <mml:mrow> <mml:mi>μ</mml:mi> <mml:mi>b</mml:mi> <mml:mo>/</mml:mo> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:mrow> </mml:math> and $$\left. {\mathrm{d}\sigma /\mathrm{d}t}\right| _{\mathrm{bump}} = (29.7 \pm 1.8)\,\mathrm{{\mu b/GeV^2}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mfenced> <mml:mrow> <mml:mi>d</mml:mi> <mml:mi>σ</mml:mi> <mml:mo>/</mml:mo> <mml:mi>d</mml:mi> <mml:mi>t</mml:mi> </mml:mrow> </mml:mfenced> <mml:mi>bump</mml:mi> </mml:msub> <mml:mo>=</mml:mo> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>29.7</mml:mn> <mml:mo>±</mml:mo> <mml:mn>1.8</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mspace /> <mml:mrow> <mml:mi>μ</mml:mi> <mml:mi>b</mml:mi> <mml:mo>/</mml:mo> <mml:msup> <mml:mi>GeV</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:mrow> </mml:mrow> </mml:math> , for the dip and the bump, respectively.

Abstract The TOTEM experiment, small in size compared to the others at the LHC, is dedicated to the measurement of the total proton–proton cross-sections with a luminosity-independent method and to the study of elastic and diffractive scattering at the LHC. To achieve optimum forward coverage for charged particles emitted by the pp collisions in the IP5 interaction point, two tracking telescopes, T1 and T2, will be installed on each side in the pseudo-rapidity region between 3.1 and 6.5, and Roman Pot stations will be placed at distances of 147 and 220 m from IP5. The telescope closest to the interaction point (T1, centred at z=9 m) consists of Cathode Strip Chambers (CSC), while the second one (T2, centred at 13.5 m), makes use of Gas Electron Multipliers (GEM). The proton detectors in the Roman Pots are silicon devices designed by TOTEM with the specific objective of reducing down to a few tens of microns the insensitive area at the edge. High efficiency as close as possible to the physical detector boundary is an essential feature. It maximizes the experimental acceptance for protons scattered elastically or interactively at polar angles down to a few micro-radians at IP5. To measure protons at the lowest possible emission angles, special beam optics have been conceived to optimize proton detection in terms of acceptance and resolution. The read-out of all TOTEM subsystems is based on the custom-developed digital VFAT chip with trigger capability.

The aim of the study was to determine the relative biological effectiveness (RBE) of a 60-MeV proton radiotherapy beam at the Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN) in Kraków, the first one to operate in Poland. RBE was assessed at the surviving fractions (SFs) of 0.01, 0.1, and 0.37, for normal human fibroblasts from three cancer patients. The cells were irradiated near the Bragg peak of the pristine beam and at three depths within a 28.4-mm spread-out Bragg peak (SOBP). Reference radiation was provided by 6-MV X-rays. The mean RBE value at SF = 0.01 for fibroblasts irradiated near the Bragg peak of pristine beam ranged between 1.06 and 1.15. The mean RBE values at SF = 0.01 for these cells exposed at depths of 2, 15, and 27 mm of the SOBP ranged between 0.95-1.00, 0.97-1.02, and 1.05-1.11, respectively. A trend was observed for RBE values to increase with survival level and with depth in the SOBP: at SF = 0.37 and at the depth of 27 mm, RBE values attained their maximum (1.19-1.24). The RBE values estimated at SF = 0.01 using normal human fibroblasts for the 60-MeV proton radiotherapy beam at the IFJ PAN in Kraków are close to values of 1.0 and 1.1, used in clinical practice.

The cellular track structure theory (TST), introduced by Katz in 1968, applies the concept of action cross section as the probability of targets in the radiation detector being activated to elicit the observed endpoint (e.g. cell killing). The ion beam radiation field is specified by the charge Z, speed β (or energy), fluence and linear energy transfer (LET) of the ion, rather than by its total absorbed dose or dose-averaged LET. The detector is represented by radiosensitive elements of size a0 and radiosensitivity D0, its gamma-ray response being represented by c-hit or multi-target expressions rather than by the linear-quadratic formula. Key to TST is the Dδ(r) formula describing the radial distribution of delta-ray dose (RDD) around the ion path. This formula, when folded with the dose response of the detector and radially integrated, yields the 'point target' action cross section value, σPT. The averaged value of the cross section, σ, is obtained by radially integrating the a0-averaged RDD. In the 'track width' regime which may occur at the distal end of the ion's path, the value of σ may considerably exceed its geometrical value, [Formula: see text]. Several scaling principles are applied in TST, resulting in its simple analytic formulation. Multi-target detectors, such as cells, are represented in TST by m, D0, σ0 (the 'saturation value' of the cross section which replaces a0) and κ (a 'detector saturation index'), as the fourth model parameter. With increasing LET of the ion, the two-component formulation of TST allows for successive transition from shouldered survival curves at low LET values to exponential ones at radiobiological effectiveness (RBE) maximum, followed by 'thindown' at the end of the ion track. For a given cell line, having best-fitted the four model parameters (m, D0, σ0 and κ) to an available data set of measured survival curves, TST is able to quantitatively predict cell survival and RBE for this cell line after any other ion irradiation.

Abstract Several models of Radial Dose Distribution predict that in the track core of the heavy ion, at the radial distances closer than 1 nm the local dose can exceed 100 kGy, but this prediction has never been experimentally verified. Within this work MCP-N (LiF:Mg,Cu,P) thermoluminescence (TL) detectors, which show high temperature TL glow peak structure between 350 °C and 500 °C after exposure to doses of gamma-rays as high as 1 MGy, were irradiated with Am-241 α-particles with fluences 107–1011 particles/cm2. For fluences 9 × 109 cm−2 in MCP-N TL glow curves high temperature peaks were observed which confirmed that a fraction of energy of α-particles was transferred with the local doses exceeding 50 kGy. Calculation of dose (fluence) dependent microdosimetric distributions confirmed that at these fluences and target diameters of 80 nm high dose regions do not result from overlapping of tracks. It was estimated that approximately 20% of entire energy of 5.5 MeV α-particle penetrating LiF was deposited with local doses exceeding 50 kGy.

Abstract Background For proton therapy, a relative biological effectiveness (RBE) of 1.1 has broadly been applied clinically. However, as unexpected toxicities have been observed by the end of the proton tracks, variable RBE models have been proposed. Typically, the dose‐averaged linear energy transfer (LET d ) has been used as an input variable for these models but the way the LET d was defined, calculated, or determined was not always consistent, potentially impacting the corresponding RBE value. Purpose This study compares consistently calculated LET d with other quantities as input variables for a phenomenological RBE model and attempts to determine which quantity that can best predicts proton RBE. The comparison was performed within the frame of introducing a new model for the proton RBE. Methods High‐throughput experimental setups of in vitro cell survival studies for proton RBE determination are simulated using the SHIELD‐HIT12A Monte Carlo particle transport code. Together with LET, , here called effective Q ( Q eff ), and Q are scored. Each quantity is calculated using the dose and track averaging methods, because the scoring includes all hadronic particles, all protons or only primaries. A phenomenological linear‐quadratic‐based RBE model is subsequently applied to the in vitro data with the various beam quality descriptors used as input variables and the goodness of fit is determined and compared using a bootstrapping approach. Both linear and nonlinear fit functions were tested. Results Versions of Q eff and Q outperform LET with a statistically significant margin, with the best nonlinear and linear fit having a relative root mean square error (RMSE) for RBE 2Gy ± one standard error of 1.55 ± 0.04 ( Q eff, t, primary ) and 2.84 ± 0.07 ( Q eff, d, primary ), respectively. For comparison, the corresponding best nonlinear and linear fits for LET d, all protons had a relative RMSE of 2.07 ± 0.06 and 3.39 ± 0.08, respectively. Applying Welch's t ‐test for comparing the calculated RMSE of RBE 2Gy resulted in two‐tailed p ‐values of &lt;0.002 for all Q and Q eff quantities compared to LET d, all protons . Conclusions The study shows that Q or Q eff could be better RBE descriptors that dose averaged LET.

To identify differential cellular responses after proton and photon irradiation by comparing transcriptomes of primary fibroblasts irradiated with either radiation type.A panel of primary dermal fibroblast cultures was irradiated with low and higher linear energy transfer (LET) proton beams. Cobalt-60 photon irradiation was used as reference. Dose was delivered in 3 fractions of 3.5 Gy (relative biological effectiveness) using a relative biological effectiveness of 1.1 for proton doses. Cells were harvested 2 hours after the final fraction was delivered, and RNA was purified. RNA sequencing was performed using Illumina NextSeq 500 with high-output kit. The edgeR package in R was used for differential gene expression analysis.Pairwise comparisons of the transcriptomes in the 3 treatment groups showed that there were 84 and 56 differentially expressed genes in the low LET group compared with the Cobalt-60 group and the higher LET group, respectively. The higher LET proton group and the Cobalt-60 group had the most distinct transcriptome profiles, with 725 differentially regulated genes. Differentially regulated canonical pathways and various regulatory factors involved in regulation of biological mechanisms such as inflammation, carcinogenesis, and cell cycle control were identified.Inflammatory regulators associated with the development of normal tissue complications and malignant transformation factors seem to be differentially regulated by higher LET proton and Cobalt-60 photon irradiation. The reported transcriptome differences could therefore influence the progression of adverse effects and the risk of developing secondary cancers.

<h2>Abstract</h2> In proton therapy, secondary fragments are created in nuclear interactions of the beam with the target nuclei. The secondary fragments have low kinetic energies and high atomic numbers as compared to primary protons. Fragments have a high LET and deposit all their energy close to the generation point. For their characteristics, secondary fragments can alter the dose distribution and lead to an increase of RBE for the same delivered physical dose. Moreover, the radiobiological impact of target fragmentation is significant mostly in the region before the Bragg peak, where generally healthy tissues are present, and immediately after Bragg peak. Considering the high biological impact of those particles, especially in the case of healthy tissues or organs at risk, the inclusion of target fragmentation processes in the dose calculation of a treatment planning system can be relevant to improve the treatment accuracy and for this reason it is one of the major tasks of the MoVe IT project. In this study, Monte Carlo simulations were employed to fully characterize the mixed radiation field generated by target fragmentation in proton therapy. The dose averaged LET has been evaluated in case of a Spread Out Bragg Peak (SOBP). Starting from LET distribution, RBE has been evaluated with two different phenomenological models. In order to characterize the mixed radiation field, the production cross section has been evaluated by means of the FLUKA code. The future development of present work is to generate a MC database of fragments fluence to be included in TPS.

A ripple filter (RiFi) is a passive energy modulator used in scanned particle therapy to broaden the Bragg peak, thus lowering the number of accelerator energies required for homogeneous target coverage, which significantly reduces the irradiation time. As we have previously shown, a new 6 mm thick RiFi with 2D groove shapes produced with 3D printing can be used in carbon ion treatments with a similar target coverage and only a marginally worse planning conformity compared to treatments with in-use 3 mm thick RiFis of an older 1D design. Where RiFis are normally not used with protons due to larger scattering and straggling effects, this new design would be beneficial in proton therapy too. Measurements of proton Bragg curves and lateral beam profiles were carried out for different RiFi designs and thicknesses as well as for no RiFi at the Heidelberg Ionenstrahl-Therapiezentrum. Base data for proton treatment planning were generated with the Monte Carlo code SHIELD-HIT12A with and without the 2D 6 mm RiFi. Plans on spherical targets in water were calculated with TRiP98 for a systematic RiFi performance analysis and for comparisons with carbon ion plans for the same respective energy depth step sizes. Plans for 9 stage I static non small cell lung cancer patients were calculated with Eclipse 13.7.15. Dose-volume-histograms, spatial dose distributions and dosimetric indexes were used for plan evaluation. Measurements confirm the functionality of the new 2D RiFi design, which reduces the beam spot size compared to 1D RiFis of the same thickness. Planning studies show that a 6 mm thick 2D RiFi could be used in proton therapy to lower the irradiation time. Although slightly worse planning conformity and dose homogeneity were found for plans with the RiFi compared to plans without, satisfactory results within the planning objective were obtained for all cases.

The TOTEM collaboration has measured the proton-proton total cross section at $\sqrt{s}=13$ TeV with a luminosity-independent method. Using dedicated $β^{*}=90$ m beam optics, the Roman Pots were inserted very close to the beam. The inelastic scattering rate has been measured by the T1 and T2 telescopes during the same LHC fill. After applying the optical theorem the total proton-proton cross section is $σ_{\rm tot}=(110.6 \pm 3.4$) mb, well in agreement with the extrapolation from lower energies. This method also allows one to derive the luminosity-independent elastic and inelastic cross sections: $σ_{\rm el} = (31.0 \pm 1.7)$ mb and $σ_{\rm inel} = (79.5 \pm 1.8)$ mb.

Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. This is partially due to the difficult characterization of the irradiation field. The detection of low energetic fragments, secondary protons and fragments, is in fact challenging due to their very short range. However, considering their low residual energy and therefore high LET, the possible contribution of such heavy particles to the overall biological effect could be not negligible. In this context, we performed a systematic analysis aimed at an explicit assessment of the RBE (relative biological effectiveness, i.e., the ratio of photon to proton physical dose needed to achieve the same biological effect) contribution of target fragments in the biological dose calculations of proton fields. The TOPAS Monte Carlo code has been used to characterize the radiation field, i.e., for the scoring of primary protons and fragments in an exemplary water target. TRiP98, in combination with LEM IV RBE tables, was then employed to evaluate the RBE with a mixed field approach accounting for fragments' contributions. The results were compared with that obtained by considering only primary protons for the pristine beam and spread out Bragg peak (SOBP) irradiations, in order to estimate the relative weight of target fragments to the overall RBE. A sensitivity analysis of the secondary particles production cross-sections to the biological dose has been also carried out in this study. Finally, our modeling approach was applied to the analysis of a selection of cell survival and RBE data extracted from published in vitro studies. Our results indicate that, for high energy proton beams, the main contribution to the biological effect due to the secondary particles can be attributed to secondary protons, while the contribution of heavier fragments is mainly due to helium. The impact of target fragments on the biological dose is maximized in the entrance channels and for small α/β values. When applied to the description of survival data, model predictions including all fragments allowed better agreement to experimental data at high energies, while a minor effect was observed in the peak region. An improved description was also obtained when including the fragments' contribution to describe RBE data. Overall, this analysis indicates that a minor contribution can be expected to the overall RBE resulting from target fragments. However, considering the fragmentation effects can improve the agreement with experimental data for high energy proton beams.

The transcriptional response of cells exposed to proton radiation is not equivalent to the response induced by traditional photon beams. Changes in cellular signalling is most commonly studied using the method Quantitative polymerase chain reaction (qPCR). Stable reference genes must be used to accurately quantify target transcript expression. The study aim was to identify suitable reference genes for normalisation of gene expression levels in normal dermal fibroblasts irradiated with either proton or photon beams. The online tool RefFinder was used to analyse and identify the most stably expressed genes from a panel of 22 gene candidates. To assess the reliability of the identified reference genes, a selection of the most and least stable reference genes was used to normalise target transcripts of interest. Fold change levels varied considerably depending on the used reference gene. The top ranked genes IPO8, PUM1, MRPL19 and PSMC4 produced highly similar target gene expression, while expression using the worst ranked genes, TFRC and HPRT1, was clearly modified due to reference gene instability.

An algorithm was developed of a treatment planning system (TPS) kernel for carbon radiotherapy in which Katz's Track Structure Theory of cellular survival (TST) is applied as its radiobiology component. The physical beam model is based on available tabularised data, prepared by Monte Carlo simulations of a set of pristine carbon beams of different input energies. An optimisation tool developed for this purpose is used to find the composition of pristine carbon beams of input energies and fluences which delivers a pre-selected depth-dose distribution profile over the spread-out Bragg peak (SOBP) region. Using an extrapolation algorithm, energy-fluence spectra of the primary carbon ions and of all their secondary fragments are obtained over regular steps of beam depths. To obtain survival vs. depth distributions, the TST calculation is applied to the energy-fluence spectra of the mixed field of primary ions and of their secondary products at the given beam depths. Katz's TST offers a unique analytical and quantitative prediction of cell survival in such mixed ion fields. By optimising the pristine beam composition to a published depth-dose profile over the SOBP region of a carbon beam and using TST model parameters representing the survival of CHO (Chinese Hamster Ovary) cells in vitro, it was possible to satisfactorily reproduce a published data set of CHO cell survival vs. depth measurements after carbon ion irradiation. The authors also show by a TST calculation that 'biological dose' is neither linear nor additive.

Radiotherapy beams of protons or heavier ions generate secondary particles through nuclear interactions over different patient tissues. The resulting particle spectra depend on the tissue composition and on charge and energy of the primary beam ions. In proton radiotherapy, predictive radiobiological models usually apply dose-averaged linear energy transfer (LET). Microdosimetry-based models for proton or heavier ion primary beams also rely on dose-averaged quantities, the values of which depend on whether the produced secondaries are included or excluded in the calculation. In turn, this will affect the results of calculations of the relative biological effectiveness (RBE) of these beams. In this brief note, we study quantitatively the influence of the secondary radiation spectra on the averaged expectation values of LET and their impact on predictions of RBE. It is noted that for microdosimetry-based quantities and for corresponding LET-based parameters the trends are similar and that fluence-averaged quantities should be studied more closely.

In track structure theory, the radial distribution of dose, D(r), around an ion track plays a fundamental role in predicting the response of biological systems and physical detectors after a dose (or fluence) of ions. According to the formulations of D(r), the local dose at radial distances below 1 nm can reach values as high as 10 6 Gy. We propose a new method of verifying experimentally the radial dose distribution around α-particle tracks, using LiF:Mg,Cu,P (MCP-N) thermoluminescent detectors (TLD) which are able to measure γ-ray doses in the kGy range via evaluation of their high-temperature TL glow peak structure over the temperature range of 350-550°C. MCP-N detectors were irradi- ated with Am-241 α-particles at fluences ranging from 10 7 to 10 11 particles/cm 2 , and by Co-60 γ-ray doses ranging from several Gy up to the MGy. A number N of individual high-temperature TL peaks were analysed in the obtained glow curves by deconvolution, using the GlowFit code. For each of these peaks, an equation relating the intensity, A, of the TL signal obtained after α-particle irradiation and after γ-ray doses, via the dose-frequency function, f α (D), was written in the form: . Using this set of N equations, where Aα i and Aγ i (D) were known (measured), the single unknown function f α (D) was unfolded and converted to D(r). Parametric unfolding and the SAND-II iterative code were applied. While we were able to confirm the 1/r 2 dependence of D(r) in agreement with D(r) expressions, we were unable to conclusively evaluate the dependence of D(r) at intermediate ranges of radial dis- tance r. This preliminary result of our unique experimental approach to determine the radial dose distribution around the path of heavy charged particles in LiF detectors, requires further development.

The High-Energy Physics community faces new data processing challenges caused by the expected growth of data resulting from the upgrade of LHC accelerator. These challenges drive the demand for exploring new approaches for data analysis. In this paper, we present a new declarative programming model extending the popular ROOT data analysis framework, and its distributed processing capability based on Apache Spark. The developed framework enables high-level operations on the data, known from other big data toolkits, while preserving compatibility with existing HEP data files and software. In our experiments with a real analysis of TOTEM experiment data, we evaluate the scalability of this approach and its prospects for interactive processing of such large data sets. Moreover, we show that the analysis code developed with the new model is portable between a production cluster at CERN and an external cluster hosted in the Helix Nebula Science Cloud thanks to the bundle of services of Science Box.

Journal Article The application of amorphous track models to study cell survival in heavy ions beams Get access L. Grzanka, L. Grzanka 1Polish Academy of Science, Institute of Nuclear Physics, ul. Radzikowskiego 152, 31-342 Krakow, Poland Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Greilich, S. Greilich 2Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Korcyl, M. Korcyl 3Institute of Physics, Jagiellonian University, ul. Reymonta 4, 30-059 Krakow, Poland Search for other works by this author on: Oxford Academic PubMed Google Scholar O. Jäkel, O. Jäkel 2Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Waligórski, M. Waligórski 4The Maria Sklodowska-Curie Centre of Oncology, Krakow Division, ul. Garncarska 11, 31-115 Krakow, Poland Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Olko P. Olko * 1Polish Academy of Science, Institute of Nuclear Physics, ul. Radzikowskiego 152, 31-342 Krakow, Poland *Corresponding author: pawel.olko@ifj.edu.pl Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 143, Issue 2-4, February 2011, Pages 232–236, https://doi.org/10.1093/rpd/ncq516 Published: 12 January 2011

Solid state dosimetry in therapeutic ion beams is seriously hampered by ionisation density effects. In most cases the use of empirical corrections is limited and therefore model predictions, especially from amorphous track models (ATMs), play a major role. Due to its high saturation dose and simple dose response, the alanine detector can help to study fundamental assumptions and accuracy in amorphous track modelling. The libamtrack project enabled recently to directly compare various flavours of ATMs. We therefore present here the potential of predictions for alanine from two libamtrack ATMs with experimental data as first part of a greater study. We find very good agreement for protons, helium and carbon ions for thin targets. For thick targets, however, the two compared algorithms show differences, with one generally better matching the data. Additional assumptions which have to be made on particle transport and stopping powers hinders a thorough interpretation of the deviation found and stress the necessity for a broader data base at lower particle energies.

Proton radiotherapy requires precise knowledge of the volumetric dose distribution. In proton beam delivery systems, based on narrow pencil beams, a contribution from small doses in low-intensity regions, consisting mainly of scattered protons, may have not negligible influence on total dose delivered to patient. Insufficient information about dose profile can cause underestimation of dose and potential delivery of inflated dose during hadrontherapy treatment. Presented work aims to verify applicability of diamond detectors, produced by Chemical Vapor Deposition method, for therapeutic proton beam profilometry at large fields. This requires the capability of measuring the core of the beam intensity profile (wide dynamic range) as well as its lateral spread (very high sensitivity) with a single device.

The TOTEM experiment is dedicated to the measurement of the total proton–proton cross-section with the luminosity-independent method and the study of elastic and diffractive scattering processes. Two tracking telescopes, T1 and T2, integrated in the CMS detector, cover the pseudo-rapidity region between 3.1 and 6.5 on both sides of the interaction point IP5. The Roman Pot (RP) stations are located at distances of ±147 m and ±220 m with respect to the interaction point to measure the very forward scattered protons at very small angles. During the LHC technical stop in winter 2010/2011, the TOTEM experiment was completed with the installation of the T1 telescope and the RP stations at ±147 m. In 2011, the LHC machine provided special optics with the large ß⁎=90 m, allowing TOTEM to measure the elastic scattering differential cross-section, down to the four-momentum transfer squared |t|=2×10−2 GeV2. Using the optical theorem and extrapolation of the differential cross-section to t=0 (optical point), the total p–p cross-section at the LHC energy of s=7TeV could be computed for the first time. Furthermore we measured with standard LHC beam optics and the energy of s=7TeV the forward charged particle pseudorapidity density dn/dη in the range of 5.3<|η|<6.4. The status of the experiment, the performance of the detectors with emphasis on the RPs are described and the first physics results are presented.

The authors describe a numerical algorithm to optimise the entrance spectra of a composition of pristine carbon ion beams which delivers a pre-assumed dose-depth profile over a given depth range within the spread-out Bragg peak. The physical beam transport model is based on tabularised data generated using the SHIELD-HIT10A Monte-Carlo code. Depth-dose profile optimisation is achieved by minimising the deviation from the pre-assumed profile evaluated on a regular grid of points over a given depth range. This multi-dimensional minimisation problem is solved using the L-BFGS-B algorithm, with parallel processing support. Another multi-dimensional interpolation algorithm is used to calculate at given beam depths the cumulative energy-fluence spectra for primary and secondary ions in the optimised beam composition. Knowledge of such energy-fluence spectra for each ion is required by the mixed-field calculation of Katz's cellular Track Structure Theory (TST) that predicts the resulting depth-survival profile. The optimisation algorithm and the TST mixed-field calculation are essential tools in the development of a one-dimensional kernel of a carbon ion therapy planning system. All codes used in the work are generally accessible within the libamtrack open source platform.

Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical prescription, finds the optimum distribution of cancer cells to be inactivated by their irradiation over the tumour volume, is a basic procedure of cancer radiotherapy. The main difficulty encountered in therapy planning for ion radiotherapy is to correctly account for the enhanced radiobiological effectiveness of ions in the Spread Out Bragg Peak (SOBP) region over the tumour volume. In this case, unlike in conventional radiotherapy with photon beams, achieving a uniform dose distribution over the tumour volume does not imply achieving uniform cancer cell inactivation. In this thesis, an algorithm of the basic element (kernel) of a treatment planning system (TPS) for carbon ion therapy is developed. The algorithm consists of a radiobiological part which suitably corrects for the enhanced biological effect of ion irradiation of cancer cells, and of a physical beam transport model. In the radiobiological component, Katz's track structure model of cellular survival is applied, after validating its physical assumptions and improving some aspects of this model. The Katz model offers fast and accurate predictions of cell survival in mixed fields of the primary carbon ions and of their secondary fragments. The physical beam model was based on available tabularized data, prepared earlier by Monte Carlo simulations. Both components of the developed TPS kernel are combined within an optimization tool, allowing the entrance energy-fluence spectra of the carbon ion beam to be selected in order to achieve a pre-assumed uniform (flat) depth-survival profile over the SOBP region, assuring uniform cancer cell inactivation over the tumour depth.

Measurements from particle timing detectors are often affected by the time walk effect caused by statistical fluctuations in the charge deposited by passing particles. The constant fraction discriminator (CFD) algorithm is frequently used to mitigate this effect both in test setups and in running experiments, such as the CMS-PPS system at the CERN's LHC. The CFD is simple and effective but does not leverage all voltage samples in a time series. Its performance could be enhanced with deep neural networks, which are commonly used for time series analysis, including computing the particle arrival time. We evaluated various neural network architectures using data acquired at the test beam facility in the DESY-II synchrotron, where a precise MCP (MicroChannel Plate) detector was installed in addition to PPS diamond timing detectors. MCP measurements were used as a reference to train the networks and compare the results with the standard CFD method. Ultimately, we improved the timing precision by 8% to 23%, depending on the detector's readout channel. The best results were obtained using a UNet-based model, which outperformed classical convolutional networks and the multilayer perceptron.

The High Energy Physics community has been developing dedicated solutions for processing experiment data over decades. However, with recent advancements in Big Data and Cloud Services, a question of application of such technologies in the domain of physics data analysis becomes relevant. In this paper, we present our initial experience with a system that combines the use of public cloud infrastructure (Helix Nebula Science Cloud), storage and processing services developed by CERN, and off-the-shelf Big Data frameworks. The system is completely decoupled from CERN main computing facilities and provides an interactive web-based interface based on Jupyter Notebooks as the main entry-point for the users. We run a sample analysis on 4.7 TB of data from the TOTEM experiment, rewriting the analysis code to leverage the PyRoot and RDataFrame model and to take full advantage of the parallel processing capabilities offered by Apache Spark. We report on the experience collected by embracing this new analysis model: preliminary scalability results show the processing time of our dataset can be reduced from 13 hrs on a single core to 7 mins on 248 cores.

Ion beams passing through lung tissue show more pronounced energy straggling than expected for solid materials of the same thickness. Energy straggling in active scanning particle therapy can enlarge the pencil beam Bragg peaks in-depth as well as displace them, deteriorating the dose coverage of a target within the lung. While this is not yet considered in any known treatment planning system, we implement a mathematical model to be used for treatment planning using TRiP98, which relies on a deterministic pencil beam algorithm. Through a randomization process based on a continuous Poisson probability distribution, the HU values of lung voxels are replaced with a modified value in succesive iterations. The beam-modulation effect of the lung can thus be taken into account in treatment planning by recalculating the dose n times for n randomized CTs using the raster scan file of a plan which was optimized on the nonmodulated CT. The evaluation follows by averaging the resulting n dose distributions and comparing to the corresponding nonmodulated dose distribution attending at dosimetric indices and dose-volume histograms. In this work, the functionality of these routines was tested for proton and carbon ion plans for two selected lung cancer patient cases with deep-seated tumors, showing that with existing standard tools it is possible to calculate the beam-modulation effect of the lung in TRiP98 in a transparent way. Variable model parameters such as modulation power, voxel size and density voxel selection range were evaluated. Furthermore, a systematic study for spherical geometries in a lung tissue CT cube is presented to investigate general trends.

Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical prescription, finds the optimum distribution of cancer cells to be inactivated by their irradiation over the tumour volume, is a basic procedure of cancer radiotherapy. The main difficulty encountered in therapy planning for ion radiotherapy is to correctly account for the enhanced radiobiological effectiveness of ions in the Spread Out Bragg Peak (SOBP) region over the tumour volume. In this case, unlike in conventional radiotherapy with photon beams, achieving a uniform dose distribution over the tumour volume does not imply achieving uniform cancer cell inactivation. In this thesis, an algorithm of the basic element (kernel) of a treatment planning system (TPS) for carbon ion therapy is developed. The algorithm consists of a radiobiological part which suitably corrects for the enhanced biological effect of ion irradiation of cancer cells, and of a physical beam transport model. In the radiobiological component, Katz's track structure model of cellular survival is applied, after validating its physical assumptions and improving some aspects of this model. The Katz model offers fast and accurate predictions of cell survival in mixed fields of the primary carbon ions and of their secondary fragments. The physical beam model was based on available tabularized data, prepared earlier by Monte Carlo simulations. Both components of the developed TPS kernel are combined within an optimization tool, allowing the entrance energy-fluence spectra of the carbon ion beam to be selected in order to achieve a pre-assumed uniform (flat) depth-survival profile over the SOBP region, assuring uniform cancer cell inactivation over the tumour depth.

The TOTEM experiment is dedicated to the measurement of the total proton-proton cross-section with the luminosity-independent method and the study of elastic and diffractive scattering processes. Two tracking telescopes, T1 and T2, integrated in the CMS detector, cover the pseudo-rapidity region between 3.1 and 6.5 on both sides of the interaction point IP5. The Roman Pot (RP) stations are located at distances of ± 147m and ± 220 m with respect to the interaction point to measure the very forward scattered protons at very small angles. During the LHC technical stop in winter 2010/2011, the TOTEM experiment was completed with the installation of the T1 telescope and the RP stations at ± 147 m. In 2011, the LHC machine provided special optics with the large ß* = 90 m, allowing TOTEM to measure the elastic scattering differential cross section, down to the four-momentum transfer squared |t| = 2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−2</sup> GeV <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Using the optical theorem and extrapolation of the differential cross section to t = 0 (optical point), the total p-p cross section at the LHC energy of √v = 7 TeV could be computed for the first time. The status of the experiment, the performance of the detectors with emphasis on the RPs are described and the first physics results are presented.

The pseudorapidity density of charged particles dN(ch)/deta is measured by the TOTEM experiment in pp collisions at sqrt(s) = 8 TeV within the range 3.9 &lt; eta &lt; 4.7 and -6.95 &lt; eta &lt; -6.9. Data were collected in a low intensity LHC run with collisions occurring at a distance of 11.25 m from the nominal interaction point. The data sample is expected to include 96-97\% of the inelastic proton-proton interactions. The measurement reported here considers charged particles with p_T &gt; 0 MeV/c, produced in inelastic interactions with at least one charged particle in -7 &lt; eta &lt; -6 or 3.7 &lt; eta &lt;4.8 . The dN(ch)/deta has been found to decrease with |eta|, from 5.11 +- 0.73 at eta = 3.95 to 1.81 +- 0.56 at eta= - 6.925. Several MC generators are compared to the data and are found to be within the systematic uncertainty of the measurement.

Proton-proton elastic scattering has been measured by the TOTEM experiment at the CERN Large Hadron Collider at $\sqrt{s} = 7 $ TeV in special runs with the Roman Pot detectors placed as close to the outgoing beam as seven times the transverse beam size. The differential cross-section measurements are reported in the |t|-range of 0.36 to 2.5 GeV^2. Extending the range of data to low t values from 0.02 to 0.33 GeV^2,and utilizing the luminosity measurements of CMS, the total proton-proton cross section at sqrt(s) = 7 TeV is measured to be (98.3 +- 0.2(stat) +- 2.8(syst)) mb.

The first physics results from the TOTEM experiment are here reported, concerning the measurements of the total, differential elastic, elastic and inelastic pp cross-section at the LHC energy of $\sqrt{s}$ = 7 TeV, obtained using the luminosity measurement from CMS. A preliminary measurement of the forward charged particle $\eta$ distribution is also shown.

The first physics results from the TOTEM experiment are here reported, concerning the measurements of the total, differential elastic, elastic and inelastic pp cross-section at the LHC energy of $\sqrt{s}$ = 7 TeV, obtained using the luminosity measurement from CMS. A preliminary measurement of the forward charged particle $η$ distribution is also shown.

V. Avati , M. Berretti, M. Besta, E. Brucken, P. Dadel, F. Ferro, F. Garcia, S. Giani, L. Grzanka, J. Hallila, P. Janhunen , J. Kaspar, G. Latino, R. Leszko, D. Mierzejewski, H. Niewiadomski, T. Novak, T. Nuotio, E. Oliveri, K. Osterberg, F. Oljemark, S. Sadilov, M. Tuhkanen , T. Vihanta, M. Zalewski, Z. Zhang, J. Welti Case Western Reserve University, Dept. of Physics, Cleveland, OH, USA CERN, Geneve, Switzerland Helsinki Institute of Physics and Dept. of Physics, University of Helsinki,Finland Institute of Physics of the Academy of Sciences, Praha, Czech Republic MTA KFKI RMKI, Budapest, Hungary INFN Sezione di Genova, Italy Universita di Siena and INFN Sezione di Pisa, Italy On leave from AGH Univ. of Sci. and Technology, Krakow, Poland On leave from University of Applied Sciences, Rovaniemi, Finland ∗Corresponding Author E-mail: valentina.avati@cern.ch

Neural network models for processing of ultrasound rodents recordings to be used with custom software dedicated to detection and classification of USV.

This dataset contains results of MC simulations for calculating LET, and derived quantities.

This dataset contains results of MC simulations for calculating LET, and derived quantities.

Neural network models for processing of ultrasound rodents recordings to be used with custom software dedicated to detection and classification of USV.

This research was supported in part by PL-Grid Infrastructure and by the Horizont 2020 project INSPIRE Grant 730983.

The dataset includes data from<em> in vitro</em> experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading, preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks. The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological <em>in vivo</em> mouse experiments (folder „mc_simulation”). <strong>ACKNOWLEDGEMENTS</strong> <strong>K. Jeleń acknowledges the support of InterDokMed project No. POWR.03.02.00-00-I013/16 </strong>

The dataset includes data from<em> in vitro</em> experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading, preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks. The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological <em>in vivo</em> mouse experiments (folder „mc_simulation”). <strong>ACKNOWLEDGEMENTS</strong> <strong>K. Jeleń acknowledges the support of InterDokMed project No. POWR.03.02.00-00-I013/16 </strong>

The TOTEM experiment at the LHC has performed the first measurement at $\sqrt{s} = 13$ TeV of the $ρ$ parameter, the real to imaginary ratio of the nuclear elastic scattering amplitude at $t=0$, obtaining the following results: $ρ= 0.09 \pm 0.01$ and $ρ= 0.10 \pm 0.01$, depending on different physics assumptions and mathematical modelling. The unprecedented precision of the $ρ$ measurement, combined with the TOTEM total cross-section measurements in an energy range larger than 10 TeV (from 2.76 to 13 TeV), has implied the exclusion of all the models classified and published by COMPETE. The $ρ$ results obtained by TOTEM are compatible with the predictions, from alternative theoretical models both in the Regge-like framework and in the QCD framework, of a colourless 3-gluon bound state exchange in the $t$-channel of the proton-proton elastic scattering. On the contrary, if shown that the 3-gluon bound state $t$-channel exchange is not of importance for the description of elastic scattering, the $ρ$ value determined by TOTEM would represent a first evidence of a slowing down of the total cross-section growth at higher energies. The very low-$|t|$ reach allowed also to determine the absolute normalisation using the Coulomb amplitude for the first time at the LHC and obtain a new total proton-proton cross-section measurement $σ_{tot} = 110.3 \pm 3.5$ mb, completely independent from the previous TOTEM determination. Combining the two TOTEM results yields $σ_{tot} = 110.5 \pm 2.4$ mb.

Emf 技术被采用根据计划作为稳固的电解质与 yttria-stabilised-zirconia 用流电的房间在 liquidAg-In-Pd 合金决定铟活动：kanthal/rhenium， Ag-In-Pd， In_2O_3 ∣Y SZ ∣ Ni， NiO，磅。作文和温度测量范围被限制，因为很陡峭的液体我们表面；为直到 0.3 的 X_(pd ) 的 35 篇作文被调查并且在从直到 1700 K 的 near-liquidus 的温度。高温度实验要求了特殊黄花茗葱炉子为弯屈保护的空气的炉子与唯一的自动煤气的供应系统被构造。Emf 读物被自动数据获得系统拿并且记录。温度上的 emf 的线性依赖为调查的所有作文被观察，并且结果被直线方程接近。当时在活动是计算的使用著名关系并且为在 kanthal 和铂之间的热电的电源考虑修正。结果将与另外的存在数据一起被过去常在一致下面执行对三元系统的评价。

Datasets used in Bellinzona, E.V.; Grzanka, L.; Attili, A.; Tommasino, F.; Friedrich, T.; Krämer, M.; Scholz, M.; Battistoni, G.; Embriaco, A.; Chiappara, D.; Cirrone, G.A.P.; Petringa, G.; Durante, M.; Scifoni, E. Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach. <em>Cancers</em> <strong>2021</strong>, <em>13</em>, 4768. https://doi.org/10.3390/cancers13194768

Datasets used in Bellinzona, E.V.; Grzanka, L.; Attili, A.; Tommasino, F.; Friedrich, T.; Krämer, M.; Scholz, M.; Battistoni, G.; Embriaco, A.; Chiappara, D.; Cirrone, G.A.P.; Petringa, G.; Durante, M.; Scifoni, E. Biological Impact of Target Fragments on Proton Treatment Plans: An Analysis Based on the Current Cross-Section Data and a Full Mixed Field Approach. <em>Cancers</em> <strong>2021</strong>, <em>13</em>, 4768. https://doi.org/10.3390/cancers13194768