Juan Pablo Fernández Ramos

Summary Triple negative breast cancer is an aggressive form of breast cancer. Despite treatment with chemotherapy, relapses are frequent and response to these treatments is not the same in younger women as in older women. Therefore, the identification of genes that cause this difference is required. The identification of therapeutic targets is one of the sought after goals to develop new drugs. Within the range of different hybridization techniques, the developed system uses expression array analysis to measure the expression of the signal levels of thousands of genes in a given sample. Probesets of Gene 1.0 ST GeneChip arrays provide categorical genome transcript coverage, providing a measurement of the expression level of the sample. This paper proposes a multi-agent system to manage information of expression arrays, with the goal of providing an intuitive system that is also extensible to analyze and interpret the results. The roles of agent integrate different types of techniques, statistical and data mining methods that select a set of genes, searching techniques that find pathways in which such genes participate, and an information extraction procedure that applies a CBR system to check if these genes are involved in the disease.

Latin American (LATAM) contributions to Music Technology date back to the early 1940’s. However, as evidenced in historical analyses of NIME, the input from LATAM institutions to its proceedings is considerably low, even when the conference was recently held in Porto Alegre, Brazil. Reflecting on this visible disparity and joining efforts as a group of LATAM researchers, we conducted a workshop and distributed a survey with members of the LATAM community with the aim of sounding out their perspectives on NIME-related practices and the prospect of establishing a LATAM NIME Network. Based on our findings we provide a contemporary contextual overview of the activities happening in LATAM and the particular challenges that practitioners face emerging from their socio-political reality. We also offer LATAM perspectives on critical epistemological issues that affect the NIME community as a whole, contributing to a pluriversal view on these matters, and to the embracement of multiple realities and ways of doing things.

Operationalizing AI fairness at LinkedIn's scale is challenging not only because there are multiple mutually incompatible definitions of fairness but also because determining what is fair depends on the specifics and context of the product where AI is deployed. Moreover, AI practitioners need clarity on what fairness expectations need to be addressed at the AI level. In this paper, we present the evolving AI fairness framework used at LinkedIn to address these three challenges. The framework disentangles AI fairness by separating out equal treatment and equitable product expectations. Rather than imposing a trade-off between these two commonly opposing interpretations of fairness, the framework provides clear guidelines for operationalizing equal AI treatment complemented with a product equity strategy. This paper focuses on the equal AI treatment component of LinkedIn's AI fairness framework, shares the principles that support it, and illustrates their application through a case study. We hope this paper will encourage other big tech companies to join us in sharing their approach to operationalizing AI fairness at scale, so that together we can keep advancing this constantly evolving field.

The CMS drift tubes (DT) muon detector, built for withstanding the LHC expected integrated and instantaneous luminosities, will be used also in the High Luminosity LHC (HL-LHC) at a 5 times larger instantaneous luminosity and, consequently, much higher levels of radiation, reaching about 10 times the LHC integrated luminosity. Initial irradiation tests of a spare DT chamber at the CERN gamma irradiation facility (GIF++), at large (∼ O(100)) acceleration factor, showed ageing effects resulting in a degradation of the DT cell performance. However, full CMS simulations have shown almost no impact in the muon reconstruction efficiency over the full barrel acceptance and for the full integrated luminosity. A second spare DT chamber was moved inside the GIF++ bunker in October 2017. The chamber was being irradiated at lower acceleration factors, and only 2 out of the 12 layers of the chamber were switched at working voltage when the radioactive source was active, being the other layers in standby. In this way the other non-aged layers are used as reference and as a precise and unbiased telescope of muon tracks for the efficiency computation of the aged layers of the chamber, when set at working voltage for measurements. An integrated dose equivalent to two times the expected integrated luminosity of the HL-LHC run has been absorbed by this second spare DT chamber and the final impact on the muon reconstruction efficiency is under study. Direct inspection of some extracted aged anode wires presented a melted resistive deposition of materials. Investigation on the outgassing of cell materials and of the gas components used at the GIF++ are underway. Strategies to mitigate the ageing effects are also being developed. From the long irradiation measurements of the second spare DT chamber, the effects of radiation in the performance of the DTs expected during the HL-LHC run will be presented.

Abstract The buckling capacity of suction caissons during installation must be investigated, as these are sensitive to buckling due to their thin-walled structure. A geometric material nonlinear analysis with imperfections, in which the soil is modeled using continuum elements, provides the most realistic results. Nonetheless, the modeling of the nonlinear material behavior of the soil as well as the consideration of multiple imperfection shapes are associated with a high modeling and computational effort. To avoid this, springs are often used to model the soil. However, the common approaches for determining lateral soil springs were developed experimentally for flexible piles and not short caissons. In this work finite element models are created to derive adapted soil springs for large scale tests on suction caissons. The comparison of the implemented soil springs with the soil springs from the guidelines shows that an adjustment of the commonly used springs is necessary. A factor that allows the springs to approximate the behavior of the continuum elements is formulated. Additional models that analyze the supporting effect of the soil on the buckling capacity of the suction caisson using continuum finite elements and soil springs foundations are developed. These models also compare the effect of the embedment depth and the soil bearing capacity.

The presence of ten organophosphorus pesticides was studied in tomatoes acquired from markets in Bogota (Colombia), using Liquid-liquid Extraction (LLE) and High Resolution Gas Chromatography (HRGC) with flame photometric detector (FPD). The pesticides analyzed were: Chlorfevinphos, Chlorpyrifos, Demeton O, Demeton S, Dichlofenthion, Dimethoate, Famphur, Leptophos and Trichlorfon. Eighteen samples were analyzed in which fifty five percent were contaminated with Dimethoate. Dimethoate levels in the contaminated samples were below the maximun residue levels (MRL) of 1 mg/kg established by the Codex alimentarius. Residues of Methyl parathion and Chlorfevinphos were also found, below the MRL.

espanolDe nuevo hemos de dar a conocer, en tierras castellonenses, otros petroglifoides (inscultu-ras) encontrados por los amigos A. Rufino e I. Rivero. Al primero se debe el hojiforme sobre una granroca (desprendida del acantilado) en el propio cauce del barranco de las Salinas, junto al pueblo de Cirat,en la comarca del Alto Mijares; al segundo los petroglifos, igualmente en forma de hoja, de la cima delmonte Cervol, en termino de Santa Magdalena de Polpis, comarca del Baix Maestrat. Despues anadire-mos el hojiforme del barranco del Volante, encontrado por V. Giner Sospedra en 1968. Conjunto de gra-bados que, una vez mas, deberemos adscribir al esoterismo magico-religioso de la Ia Edad del Hierro DeutschErneut konnen wir in der Provinz von Castellon weitere Steininschriften be-kannt geben, die von Arturo Rufino und Ismael Rivero endeckt wonder sind. Dem Ersten ist die blatt-formige Inschrift auf einen Felsbrocken (von einen Abhang abgebrochen) im Flussbett des Salinastalesbeim Dorf Cirat am Mijares zuzuschreiben und dem Zweiten der ebenso blattformige Petroglyph auf derHohe des Bergs Cirol im Bezirk von Santa Magdalena de Pulpis in dem Gebiet des Baix Maestrat. Eshandelt sinch um Inschriften, die wir dem magischreligiosen Esotherismus der Eisenzeit zuschreibenmussen

During the High Luminosity LHC, the Drift Tube chambers installed in the CMS detector need to operate with an integrated dose ten times higher than expected at the LHC due to the increase in integrated luminosity from 300 fb-1 to 3000 fb-1. Irradiations have been performed to assess the performance of the detector under such conditions and to characterize the radiation aging of the detector. The presented analysis focuses on the behaviour of the high voltage currents and the dose measurements needed to extrapolate the results to High Luminosity conditions, using data from the photon irradiation campaign at GIF++ in 2016 as well as the efficiency analysis from the irradiation campaign started in 2017. Although the single-wire loss of high voltage gain observed of 70% is very high, the muon reconstruction efficiency is expected to decrease less than 20% during the full duration of High Luminosity LHC in the areas under highest irradiation.

Ernesto Galarza (1905–1984) was a social work scholar at San Jose State University and an advocate of social justice. He was credited with ending the Bracero program and contributed to policy changes in the health and safety of farm workers.

Se suele llamar responsabilidad social a la imputabilidad de una valoración positiva o negativa

English is a language which plays an important role in the Ecuadorian society because it is used on different fields such as business, tourism, entertainment, health. English is present in Education because it is taught in most educational institutions – at primary, secondary and higher levels – giving students the opportunity to gain competencies in a second language. Unfortunately, the lack of didactic resources to teach grammar makes the English learning process difficult and boring. Therefore, the aim of this research is to develop a storytelling to learn English grammar through comics. The methodology used is the mixed method approach – qualitative and quantitative – for the data collection. The students who participated on this research took a pre-test and a post-test in order to know the perspective of comics as well as their grammar knowledge. The comics were designed in the software Paint 3D because it makes colorful presentations and it is possible to draw on the computer’s screen by using the optical pen. The comics present grammar structures in familiar contexts to motivate comics reading. After applying comics, the results showed that students improved their grammar grades and were motived to learn grammar. A secondary goal is to promote comics as an English resource to improve the learning of different English skills.

Abstract Falls, workplace accidents, motor vehicle collisions with other vehicles, pedestrians, or stationary objects, physical assault, and interpersonal violence all result in injuries that may require evaluation and management by a trauma team. The optimal care of a patient with blunt or penetrating trauma includes a rapid but comprehensive initial assessment, prompt resuscitation, adjunct imaging, and decision-making on the need for intensive care or operative resources. This chapter provides an overview on abdominal trauma, from the initial evaluation and resuscitation, common patterns of injury, diagnostic testing, operative and non-operative management, and post-operative care. Trauma is not isolated to any particular part of the world, and resources vary. The management of injury must adapt to these variations. Where relevant, the chapter highlights these differences from the perspectives of the authors, trauma surgeons working in very different health systems, spanning three continents.

We consider the lattice models based on affine algebras described by Jimbo et al., for the algebras and by Kuniba et al. for 2 .We find a general formula for the crossing multipliers of these models, with the result that these crossing multipliers are given by the principally specialized characters of the model in question.Therefore we conjecture that the crossing multipliers in a large class of solvable interaction round the face lattice models are given by the characters of the conformal field theory on which they are based.We also elaborate on some details of the computation of the Local state probability of these models, conjecturing an expression for it.

Measurements of the associated production of vector bosons, W or Z (decaying to one or two leptons), and jets originating from heavy-flavour quarks are reported using data corresponding to integrated luminosities of 19.7 (35.7) ${\rm fb}^{-1}$, at centre-of-mass energies of 8 (13) TeV collected by the CMS detector at the CERN LHC. Total and differential cross sections as a function of several kinematic observables are measured and compared with several theoretical predictions.The production of a Z boson associated with a c-quark allows probing and constraining the charm quark content of the proton and may give insight into the existence of an intrinsic charm quark component inside the proton. The production of a W boson associated with a c-quark allows probing and constraining the strange quark content of the proton.

To sustain and extend its discovery potential, the Large Hadron Collider (LHC) will undergo a major upgrade in the coming years, referred to as High Luminosity LHC (HLLHC), aimed to increase its instantaneous luminosity, 5 times larger than the designed limit, and, consequently leading to high levels of radiation, with the goal to collect 10 times larger the original designed integrated luminosity. The drift tube chambers (DT) of CMS muon detector system is built to proficiently measure and trigger on muons in the harsh radiation environment expected during the HL-LHC era. Ageing studies are performed at the CERNs gamma ray irradiation facility (GIF++) by measuring the muon hit efficiency of these detectors at various LHC operation conditions. One such irradiation campaign was started in October 2017, when a spare MB2 chamber moved inside the bunker and irradiated at lower acceleration factors. Two out of twelve layers of the DT chamber were operated while being irradiated with the radioactive source and then their muon hit efficiency was calculated in coincidence with other ten layers which were kept on the standby. The chamber absorbed an integrated dose equivalent to two times the expected integrated luminosity of the HL-LHC. Investigation on the outgassing of cell materials and of the gas components used at the GIF++ are underway and strategies to mitigate the aging effects are also being developed. The effect of radiation on the performance of DT chamber and its impact on the overall muon reconstruction efficiency expected during the HL-LHC are presented.

Measurements of the associated production of vector bosons, W or Z (decaying to one or two leptons), and jets originating from heavy-flavour quarks are reported using data corresponding to integrated luminosities of 19.7 (35.7) ${\small \rm fb}^{-1}$, at centre-of-mass energies of 8 (13) TeV collected by the CMS detector at the CERN LHC. Total and differential cross sections as a function of several kinematic observables are measured and compared with several theoretical predictions. The production of a Z boson associated with a c-quark allows probing and constraining the charm quark content of the proton and may give insight into the existence of an intrinsic charm quark component inside the proton. The production of a W boson associated with a c-quark allows probing and constraining the strange quark content of the proton.

Se estudio la presencia de residuos de diez plaguicidas organofosforados (POPs) en tomates adquiridos en la central de abastos y en una cadena de supermercados de Bogota, usando extraccion liquido-liquido (LLE) y determinacion analitica mediante un equipo de Cromatografia de Gases de Alta Resolucion (HRGC) - Detector Fotometrico de Llama (FPD). Los plaguicidas analizados fueron: Clorfevinfos, Clorpirifos, Demeton O, Demeton S, Diclorofention, Dimetoato, Famfur, Leptofos, Metilparation y Triclorfon. Se analizaron diez muestras obtenidas en la central mayoritaria de abastos y ocho muestras de una cadena de supermercados de las cuales el 55% presento contaminacion con Dimetoato, aunque ninguna sobrepaso el limite maximo de residuos (LMR) de 1 mg/kg establecido por el Codex alimentario. Tambien se encontraron residuos de Metilparation y Clorfevinfos, en ambos casos dentro de los limites permitidos

The presence of ten organophosphorus pesticides was studied in tomatoes acquired from markets in Bogotá (Colombia), using Liquid-liquid Extraction (LLE) and High Resolution Gas Chromatography (HRGC) with flame photometric detector (FPD). The pesticides analyzed were: Chlorfevinphos, Chlorpyrifos, Demeton O, Demeton S, Dichlofenthion, Dimethoate, Famphur, Leptophos and Trichlorfon. Eighteen samples were analyzed in which fifty five percent were contaminated with Dimethoate. Dimethoate levels in the contaminated samples were below the maximun residue levels (MRL) of 1 mg/kg established by the Codex alimentarius. Residues of Methyl parathion and Chlorfevinphos were also found, below the MRL.

The education is one of the most valuable, needed and supported aspects in human life.Realizing about the relevance of education can be done in many ways.In this paper, the author reflects one way: through an introduction of the scientific method to students.The scientific method has been introduced to pupils before high school and the qualitative results of it in terms of attention and comprehension, along with the method itself, is treated as well in this paper.In terms of attention from the pupils, a much better connection with them is achieved when the students take part in the class through questions to them or through participation in experiments along with the words and explanations needed.The same education will not be more efficient if it is not more participatory.From the human and social point of view, education is the key to mature as a society.Therefore a very important effort should be taken to not only develop the academical background, but also the human one.Learning moral and self-criticism is more than essential for us to grow as human beings: We are alone; no matter how much we are accompanied, we are the ones who live in this human body and the ones who have to take the ultimate decision whether to do this or not, to be or not to be, to do or not to do, and more than the decision itself what matters is to understand that there is a responsibility along with such a decision.

In this workshop, we propose the first steps towards consolidating a Latin American (LATAM) New Interfaces for Musical Expression (NIME) Research Community. We aim to start a discussion and generate ideas around shortterm actionable initiatives that a LATAM NIME Research Community could explore in the near future. We will discuss various topics centered around three main areas: (1) The creation of a LATAM NIME network, (2) Exploring LATAM NIME perspectives, and (3) the Next Steps for LATAM NIME. After this activity, we will have a plenary discussion where we will share ideas for action and reflections. Lastly, we list a series of expected outcomes of the workshop, although we acknowledge that many others may emerge during the workshop. We look forward to taking the first steps towards a LATAM NIME Community and the future of this community within and beyond NIME, opening to other communities in LATAM, and stirring policy changes to support the development of our local communities.


 Su objetivo general consistió en cuantificar la población residente (y no residente que utiliza servicios de salud) en el Distrito Capital que no está asegurada al sistema general de seguridad social en salud y hacer proyecciones de su dimensión en los próximos cinco años”. Como objetivos específicos se plantearon los siguientes: a) desarrollar una metodología para identificar (cuantificar) participantes vinculados con y sin capacidad de pago en el Distrito Capital y hacer una proyección de los próximos cinco años; b) estimar los recursos financieros requeridos para garantizar la prestación de los servicios de salud a la población sin capacidad de pago que no está asegurada en el régimen subsidiado y la prestación de servicios no POS-S a los afiliados al régimen subsidiado; c) presentar recomendaciones sobre el plan de transformación de subsidios de oferta a demanda.