Ankita Mehta

Glutamate is one of the most prominent neurotransmitter in the body, present in over 50% of nervous tissue and plays an important role in neuronal excitation. This neuronal excitation is short-lived and is followed by depression. Multiple abnormal triggers such as energy deficiency, oxidative stress, mitochondrial dysfunction, calcium overload, etc can lead to aberration in neuronal excitation process. Such an aberration, serves as a common pool or bridge between abnormal triggers and deleterious signaling processes with which central neurons cannot cope up, leading to death. Excitotoxicity is the pathological process by which nerve cells are damaged and killed by excessive stimulation by neurotransmitters such as glutamate and similar substances. Such excitotoxic neuronal death has been implicated in spinal cord injury, stroke, traumatic brain injury, hearing loss and in neurodegenerative diseases of the central nervous system such as stroke, epilepsy, multiple sclerosis, Alzheimer disease, Amyltropic lateral sclerosis, Parkinson’s disease, Huntington disease and alcohol withdrawal. This review mainly emphasizes the triggering events which sustain neuronal excitation, role of calcium, mitochondrial dysfunction, ROS, NO, chloride homeostasis and eicosanoids pathways. Further, a brief introduction about the recent research occurring in the treatment of various neurodegenerative diseases, including a summary of the presumed physiologic mechanisms behind the pharmacology of these disorders.

A precise determination of the energy scale of jets at the Collider Detector at Fermilab at the Tevatron pp¯ collider is described. Jets are used in many analyses to estimate the energies of partons resulting from the underlying physics process. Several correction factors are developed to estimate the original parton energy from the observed jet energy in the calorimeter. The jet energy response is compared between data and Monte Carlo simulation for various physics processes, and systematic uncertainties on the jet energy scale are determined. For jets with transverse momenta above 50 GeV the jet energy scale is determined with a 3% systematic uncertainty.

Despite novel technologies, colon cancer remains undiagnosed and 25% of patients are diagnosed with metastatic colon cancer. Resistant to chemotherapeutic agents is one of the major problems associated with treating colon cancer which creates the need to develop novel agents targeting towards newer targets. A phosphodiesterase is a group of isoenzyme, which, hydrolyze cyclic nucleotides and thereby lowers intracellular levels of cAMP and cGMP leading to tumorigenic effects. Many in vitro and in vivo studies have confirmed increased PDE expression in different types of cancers including colon cancer. cAMP-specific PDE inhibitors increase intracellular cAMP that leads to activation of effector molecules-cAMP-dependent protein kinase A, exchange protein activated by cAMP and cAMP gated ion channels. These molecules regulate cellular responses and exert its anticancer role through different mechanisms including apoptosis, inhibition of angiogenesis, upregulating tumor suppressor genes and suppressing oncogenes. On the other hand, cGMP specific PDE inhibitors exhibit anticancer effects through cGMP dependent protein kinase and cGMP dependent cation channels. Elevation in cGMP works through activation of caspases, suppression of Wnt/b-catenin pathway and TCF transcription leading to inhibition of CDK and survivin. These studies point out towards the fact that PDE inhibition is associated with anti-proliferative, anti-apoptotic and anti-angiogenic pathways involved in its anticancer effects in colon cancer. Thus, inhibition of PDE enzymes can be used as a novel approach to treat colon cancer. This review will focus on cAMP and cGMP signaling pathways leading to tumorigenesis and the use of PDE inhibitors in colon cancer.

The strong coupling constant αs is determined from inclusive jet and dijet cross sections in neutral-current deep-inelastic ep scattering (DIS) measured at HERA by the H1 collaboration using next-to-next-to-leading order (NNLO) QCD predictions. The dependence of the NNLO predictions and of the resulting value of αs(mZ) at the Z-boson mass mZ are studied as a function of the choice of the renormalisation and factorisation scales. Using inclusive jet and dijet data together, the strong coupling constant is determined to be αs(mZ)=0.1157(20)exp(29)th . Complementary, αs(mZ) is determined together with parton distribution functions of the proton (PDFs) from jet and inclusive DIS data measured by the H1 experiment. The value αs(mZ)=0.1142(28)tot obtained is consistent with the determination from jet data alone. The impact of the jet data on the PDFs is studied. The running of the strong coupling is tested at different values of the renormalisation scale and the results are found to be in agreement with expectations.

A first measurement is presented of exclusive photoproduction of $$\rho ^0$$ mesons associated with leading neutrons at HERA. The data were taken with the H1 detector in the years 2006 and 2007 at a centre-of-mass energy of $$\sqrt{s}=319$$ GeV and correspond to an integrated luminosity of 1.16 pb $$^{-1}$$ . The $$\rho ^0$$ mesons with transverse momenta $$p_T<1$$ GeV are reconstructed from their decays to charged pions, while leading neutrons carrying a large fraction of the incoming proton momentum, $$x_L>0.35$$ , are detected in the Forward Neutron Calorimeter. The phase space of the measurement is defined by the photon virtuality $$Q^2 < 2$$ GeV $$^2$$ , the total energy of the photon–proton system $$20 < W_{\gamma p}< 100$$ GeV and the polar angle of the leading neutron $$\theta _n < 0.75$$ mrad. The cross section of the reaction $$\gamma p \rightarrow \rho ^0 n \pi ^+$$ is measured as a function of several variables. The data are interpreted in terms of a double peripheral process, involving pion exchange at the proton vertex followed by elastic photoproduction of a $$\rho ^0$$ meson on the virtual pion. In the framework of one-pion-exchange dominance the elastic cross section of photon-pion scattering, $$\sigma ^\mathrm{el}(\gamma \pi ^+ \rightarrow \rho ^0\pi ^+)$$ , is extracted. The value of this cross section indicates significant absorptive corrections for the exclusive reaction $$\gamma p \rightarrow \rho ^0 n \pi ^+$$ .

Despite calls for integration into routine heart failure (HF) care, optimal palliative care delivery for people living with HF remains unclear.Describe an innovative model of an embedded palliative care nurse practitioner (NP) within a HF team. Compare demographics and utilization among people hospitalized with HF receiving referral or embedded consultation.Using an electronic health record-based palliative care registry, we conducted descriptive analyses and t-tests and χ2 tests, as appropriate, to examine bivariate associations between sociodemographic, clinical and utilization data of hospitalized people with HF receiving a traditional, referral-based palliative care consultation generated exclusively by the primary team vs. a novel, embedded-based consultation generated by collaboration between a palliative care NP and the advanced HF team at an urban, quaternary care academic medical center in New York City.During the study period from January 1, 2019-December 31, 2021, consultation volume nearly doubled with 363 consults from traditional referrals and an additional 317 consults from the newly embedded NP. People in the embedded group, as compared to referral, were younger (mean age: 60.1 vs. 71.9 years (2019); 59.2 vs. 70.4 (2020); 61.3 vs. 69.6 (2021), p-value < 0.001), more functional (median Karnofsky Performance Status: 40% vs. 30%, p-value = 0.01 (2019); 40% vs 20%, p-value < 0.0001 (2020); 40% vs. 20%, p-value = 0.02 (2021)), more likely had capacity to designate a medical decision maker (56.4% vs. 20.6%, p-value < 0.001 (2020); 76.3% vs. 49.5%, p-value < 0.001 (2021)), received earlier consultation (median days before discharge: 9.5 vs. 4 (2019); 11 vs. 5 (2020); 7 vs. 3 (2021), p-value ≤ 0.001), and more likely to discharge home (60% vs. 26%, p-value ≤ 0.001 (2019); 62.7% vs 20.6%, p-value ≤ 0.001 (2020); 42.3% vs. 28%, p-value = 0.03 (2021)).Hospitalized people living with advanced HF who received an embedded palliative care consult were younger, had higher functional status and less illness severity compared to those served by a traditional, referral-based consult.

The QED-C suite of Application-Oriented Benchmarks provides the ability to gauge performance characteristics of quantum computers as applied to real-world applications. Its benchmark programs sweep over a range of problem sizes and inputs, capturing key performance metrics related to the quality of results, total time of execution, and quantum gate resources consumed. In this manuscript, we investigate challenges in broadening the relevance of this benchmarking methodology to applications of greater complexity. First, we introduce a method for improving landscape coverage by varying algorithm parameters systematically, exemplifying this functionality in a new scalable HHL linear equation solver benchmark. Second, we add a VQE implementation of a Hydrogen Lattice simulation to the QED-C suite, and introduce a methodology for analyzing the result quality and run-time cost trade-off. We observe a decrease in accuracy with increased number of qubits, but only a mild increase in the execution time. Third, unique characteristics of a supervised machine-learning classification application are explored as a benchmark to gauge the extensibility of the framework to new classes of application. Applying this to a binary classification problem revealed the increase in training time required for larger anzatz circuits, and the significant classical overhead. Fourth, we add methods to include optimization and error mitigation in the benchmarking workflow which allows us to: identify a favourable trade off between approximate gate synthesis and gate noise; observe the benefits of measurement error mitigation and a form of deterministic error mitigation algorithm; and to contrast the improvement with the resulting time overhead. Looking ahead, we discuss how the benchmark framework can be instrumental in facilitating the exploration of algorithmic options and their impact on performance.

The H1 Collaboration reports the first measurement of the 1-jettiness event shape observable $\tau_1^b$ in neutral-current deep-inelastic electron-proton scattering (DIS). The observable $\tau_1^b$ is equivalent to a thrust observable defined in the Breit frame. The data sample was collected at the HERA $ep$ collider in the years 2003-2007 with center-of-mass energy of $\sqrt{s}=319\,\text{GeV}$, corresponding to an integrated luminosity of $351.1\,\text{pb}^{-1}$. Triple differential cross sections are provided as a function of $\tau_1^b$, event virtuality $Q^2$, and inelasticity $y$, in the kinematic region $Q^2>150\,\text{GeV}^{2}$. Single differential cross section are provided as a function of $\tau_1^b$ in a limited kinematic range. Double differential cross sections are measured, in contrast, integrated over $\tau_1^b$ and represent the inclusive neutral-current DIS cross section measured as a function of $Q^2$ and $y$. The data are compared to a variety of predictions and include classical and modern Monte Carlo event generators, predictions in fixed-order perturbative QCD where calculations up to $\mathcal{O}(\alpha_s^3)$ are available for $\tau_1^b$ or inclusive DIS, and resummed predictions at next-to-leading logarithmic accuracy matched to fixed order predictions at $\mathcal{O}(\alpha_s^2)$. These comparisons reveal sensitivity of the 1-jettiness observable to QCD parton shower and resummation effects, as well as the modeling of hadronization and fragmentation. Within their range of validity, the fixed-order predictions provide a good description of the data. Monte Carlo event generators are predictive over the full measured range and hence their underlying models and parameters can be constrained by comparing to the presented data.

The H1 Collaboration at HERA reports the first measurement of groomed event shape observables in deep inelastic electron-proton scattering (DIS) at $\sqrt{s}=319$ GeV, using data recorded between the years 2003 and 2007 with an integrated luminosity of $351$ pb$^{-1}$. Event shapes provide incisive probes of perturbative and non-perturbative QCD. Grooming techniques have been used for jet measurements in hadronic collisions; this paper presents the first application of grooming to DIS data. The analysis is carried out in the Breit frame, utilizing the novel Centauro jet clustering algorithm that is designed for DIS event topologies. Events are required to have squared momentum-transfer $Q^2 > 150$ GeV$^2$ and inelasticity $ 0.2 < y < 0.7$. We report measurements of the production cross section of groomed event 1-jettiness and groomed invariant mass for several choices of grooming parameter. Monte Carlo model calculations and analytic calculations based on Soft Collinear Effective Theory are compared to the measurements.

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the determination of clotrimazole in bulk drug and tablet dosage form. The stationary phase used was precoated silica gel 60F(254). The mobile phase used was a mixture of cyclohexane:toluene:methanol:triethyleamine (8:2:0.5:0.2 v/v/v/v). The detection of spot was carried out at 262 nm. The method was validated in terms of linearity, accuracy, precision and specificity. The calibration curve was found to be linear between 200 to 1000 ng/spot for clotrimazole. The limit of detection and the limit of quantification for clotrimazole were found to be 50 ng/spot and 200 ng/spot, respectively. The proposed method can be successfully used to determine the drug content of bulk drug and marketed formulation of tablet.

To describe a physician (MD) and registered nurse (RN) led palliative care consultation team embedded in the medical intensive care unit (MICU). To compare patterns of palliative care consultation, and rates of goals of care documentation and in-ICU mortality before and after the implementation of the embedded team.By embedding MD/RN palliative care team in the MICU, more critically ill patients with unmet palliative care needs could receive an earlier palliative care consultation.In a retrospective cohort study of patients admitted to the MICU who received a palliative care consultation, we compared sociodemographic and clinical characteristics of patients who received a referral-based consultation (01/01/2019-06/30/2019) and those who received an embedded MD/RN consult (09/01/2019-02/28/2020). Using the electronic health record data, we compared palliative care consultation characteristics, rates of documentation of medical decision-maker and goals of care, and percentage of in-ICU mortality between the referral group and the embedded group.In a six-month period, 169 MICU patients received an embedded consultation, as compared to 52 MICU patients who received a referral-based consultation. As compared to the referral-based period, those patients who received an embedded consult were seen significantly earlier in hospitalization (median number of days from hospital admission to consult: 10 days [pre] vs. 3 days [embedded], P<0.001), more likely to have documentation of medical decision-makers (40% [pre] vs. 66% [embedded], P=0.002) and goals of care (37% [pre] vs. 71% [embedded], P<0.001) and less likely to die in the hospital (75% [pre] vs. 44% [embedded], P<0.001).After embedding a palliative care MD/RN team into the MICU, patients received earlier palliative care consultation, were more likely to have medical decision-maker and goals of care documented, and less likely to die in the hospital. Future work will examine how to adapt this model to other ICUs to improve palliative care access for critically ill patients broadly.

Opioids are widely being used for chronic pain management, cough and diarrhea suppressants, anesthetic agents, and opioid de-addiction therapy. Opioid receptors, present in the central nervous system and peripheral tissues, are documented to regulate several cardiac functions through different signaling pathways. Long-acting opioids (LAO) have been successfully evaluated for their beneficial effects in various cardiovascular diseases viz. myocardial infarction, ischemic reperfusion injuries, atherosclerosis etc. However, on the other hand, several research studies pointed towards the harmful effects of LAOs which are mainly associated with QTc prolongation, torsade de pointes, ventricular arrhythmias, and cardiac arrest. This review shall familiarize readers with the benefits as well as the harmful effects of long-acting opioids in cardiovascular diseases. We have also provided an overview of cardiac opioid receptors, endogenous cardiac opioid peptides, and regulation of cardiovascular functions by central and cardiac opioid receptors.

Abstract Radiation recall dermatitis (RRD) is an extremely rare phenomenon. A variety of factors such as antineoplastic agents, pharmaceutical agents, physical and environmental factors have been proposed to be the underlying cause of RRD. Only a handful cases have been reported till date, where trastuzumab is sought to be the triggering agent. The presentation of RRD varies from mild erythematous to extensive confluent dermatitis, resolving over a period of 1 to 2 weeks with conservative management. Most of the patients tend to tolerate rechallenge well without showing reappearance. We hereby describe a lady with breast cancer having RRD following administration of trastuzumab. She developed reaction 28 days post-radiotherapy and managed conservatively. Furthermore, she was rechallenged with the same dose, that she tolerated very well, without any reappearance. Hence, an acquaintance of the clinicians to this rare entity is essential for timely diagnosis and appropriate management.

The Pixel Luminosity Telescope is a silicon pixel detector dedicated to luminosity measurement at the CMS experiment at the LHC. It is located approximately 1.75 m from the interaction point and arranged into 16 "telescopes", with eight telescopes installed around the beam pipe at either end of the detector and each telescope composed of three individual silicon sensor planes. The per-bunch instantaneous luminosity is measured by counting events where all three planes in the telescope register a hit, using a special readout at the full LHC bunch-crossing rate of 40 MHz. The full pixel information is read out at a lower rate and can be used to determine calibrations, corrections, and systematic uncertainties for the online and offline measurements. This paper details the commissioning, operational history, and performance of the detector during Run 2 (2015-18) of the LHC, as well as preparations for Run 3, which will begin in 2022.

These two data sets provide the coefficients of the parameterisation of the (L/L₀)_Opt luminosity-bias factor as a function of the normalized nominal separation, for horizontal and vertical vdM scans, respectively. The data sets are part of a paper with title "Impact of Beam-Beam Effects on Absolute Luminosity Calibrations at the CERN Large Hadron Collider" and are referred thereby as Table 10 and Table 11.

The parameters of the electroweak theory are determined in a combined electroweak and QCD analysis using all deep-inelastic $$e^+p$$ and $$e^-p$$ neutral current and charged current scattering cross sections published by the H1 Collaboration, including data with longitudinally polarised lepton beams. Various fits to Standard Model parameters in the on-shell scheme are performed. The mass of the W boson is determined as $$m_W=80.520\pm 0.115~\mathrm {GeV} $$ . The axial-vector and vector couplings of the light quarks to the Z boson are also determined. Both results improve the precision of previous H1 determinations based on HERA-I data by about a factor of two. Possible scale dependence of the weak coupling parameters in both neutral and charged current interactions beyond the Standard Model is also studied. All results are found to be consistent with the Standard Model expectations.

The strong coupling constant $\alpha_s(M_Z)$ is determined from inclusive jet and dijet cross sections in neutral-current deep-inelastic $ep$ scattering (DIS) measured at HERA by the H1 collaboration using next-to-next-to-leading order (NNLO) QCD predictions. The dependence of the NNLO predictions and of the resulting value of $\alpha_s(M_Z)$ at the $Z$-boson mass $m_Z$ are studied as a function of the choice of the renormalisation and factorisation scales. Using inclusive jet and dijet data together, the strong coupling constant is determined to be $\alpha_s(M_Z)=0.1166\,(19)_{\rm exp}\,(24)_{\rm th}$. Complementary, $\alpha_s(M_Z)$ is determined together with parton distribution functions of the proton (PDFs) from jet and inclusive DIS data measured by the H1 experiment. The value $\alpha_s(M_Z)=0.1147\,(25)_{\rm tot}$ obtained is consistent with the determination from jet data alone. The impact of the jet data on the PDFs is studied. The running of the strong coupling is tested at different values of the renormalisation scale and the results are found to be in agreement with expectations.

Recently, from the facial images, the estimation of age automatically is a raising research area.Several studies have been conducted in the detection of age strategy, however, some studies only show better performance It is because of the great control of the external metrics namely lifestyle, environment, and numerous expression that are available in the face image.The main aim of this work is to present an MLP-NN with the WOA in order to detect the age from the face image.The developed Whale MLP-NN model is used to recognize the person's age in the image via the initial training with the facial features.In order to train the adopted optimization model, the features are offered using the AAM and scattering transform.Moreover, to detect the age, the optimal weights are exploited, and that is provided by the features with the Whale MLP-NN training.Finally, the experimental analysis exhibits that the developed optimization model is performed using the databases on the basis of measures namely AEO, MAE, and AEM.

The Resistive Plate Chambers (RPCs) are employed in the CMS Experiment at the LHC as dedicated trigger system both in the barrel and in the endcap. This article presents results of the radiation background measurements performed with the 2011 and 2012 proton-proton collision data collected by CMS. Emphasis is given to the measurements of the background distribution inside the RPCs. The expected background rates during the future running of the LHC are estimated both from extrapolated measurements and from simulation.

The HL-LHC phase is designed to increase by an order of magnitude the amount of data to be collected by the LHC experiments. To achieve this goal in a reasonable time scale the instantaneous luminosity would also increase by an order of magnitude up to 6 · 1034 cm−2s−1. The region of the forward muon spectrometer (|η| > 1.6) is not equipped with RPC stations. The increase of the expected particles flux up to 2 kHz/cm2 (including a safety factor 3) motivates the installation of RPC chambers to guarantee redundancy with the CSC chambers already present. The current CMS RPC technology cannot sustain the expected background level. The new technology that will be chosen should have a high rate capability and provide a good spatial and timing resolution. A new generation of Glass-RPC (GRPC) using low-resistivity glass is proposed to equip at least the two most far away of the four high η muon stations of CMS. First the design of small size prototypes and studies of their performance in high-rate particles flux are presented. Then the proposed designs for large size chambers and their fast-timing electronic readout are examined and preliminary results are provided.

The high pseudo-rapidity region of the CMS muon system is covered by Cathode Strip Chambers (CSC) only and lacks redundant coverage despite the fact that it is a challenging region for muons in terms of backgrounds and momentum resolution. In order to maintain good efficiency for the muon trigger in this region additional RPCs are planned to be installed in the two outermost stations at low angle named RE3/1 and RE4/1. These stations will use RPCs with finer granularity and good timing resolution to mitigate background effects and to increase the redundancy of the system.

Abstract Primitive embryonal tumours of the meninges are an exceedingly rare entity and has been predominantly reported in the paediatric population. It poses a unique challenge in establishing the diagnosis as it closely resembles meningioma. This makes the incorporation of sophisticated techniques such as immunohistochemistry, molecular studies, and genetic analysis mandatory to arrive at a confirmative diagnosis. We hereby report a case of a 13-year boy who was diagnosed with primitive embryonal tumour that was initially sought to be a meningioma. Alongside, we have also included a review of literature on this entity focussing on paediatric population, where only a handful of case reports have been published till date. Although these tumours are biologically aggressive, but they tend to have good response rate with treatment. Due to rarity of this entity, consensus on the management guidelines is lacking. However, an acquaintance to this entity is important amongst neuro-oncologists to decrease the possibility of misdiagnosis and improve the cure rates and survival.

This study aimed to evaluate IP IMRT with field-in-field FP IMRT in patients undergoing adjuvant radiation after a modified radical mastectomy (MRM) for breast cancer. In the treatment of breast cancer, radiotherapy has been an essential component of the multimodality strategy. Dose distribution was improved by newer methods such as three-dimensional radiation. Intensity-modulated radiation (IMRT) improved homogeneity much further. The purpose of this study was to evaluate dosimetric characteristics and clinical results of inverse planned IMRT (IP IMRT) and field-in-field forward planned IMRT (FP IMRT) in patients with breast cancer receiving post-modified radical mastectomy (MRM) adjuvant radiation. Fifty patients with breast cancer who had MRM and needed adjuvant radiation were randomly randomized to one of two groups (25 each) using IP IMRT and FP IMRT procedures. The recommended dose was 50 Gy spread out over five weeks in 25 portions. In IP IMRT, five to seven tangential beams were employed for the chest wall, nodal volumes were set at appropriate angles using beam optimization, and the analytical anisotropic technique was used to calculate. In order to ensure uniform dose distribution to the planned target volume (PTV), minimize hot spot areas, and restrict exposure to the ipsilateral lung and contralateral breast, two opposing tangential fields were developed for FP IMRT. The dosimetric parameters in terms of PTV are better for IP IMRT plans compared to FP IMRT plans (V95%: 92.3% vs 75.2%, p = 0.0001; D90%: 47.4 Gy vs 42.9 Gy, p = 0.0001; D95%: 44.9 Gy vs 37.1, p = 0.0004). The ipsilateral lung (V10Gy: 71.9% vs 41%, p = 0.00001; V20Gy: 42.14% vs 36.35%, p = 0.03; V40Gy: 17.31% vs 26.95%, p = 0.00004; Dmean: 20.91 Gy vs 17.88 Gy, p = 0.01) and contralateral lung (V5Gy: 31.8% vs 0.1%, p &lt; 0.00001; V10Gy: 6.2% vs 0.08%, p = 0.0001) received statistically significant lesser doses in terms of low dose parameters in FP IMRT. In the heart, the dosimetric parameter V5 was significantly lower for FP IMRT (61.7% vs 9.7%, p = 0.00001) along with Dmean (10.92 Gy vs 4.01 Gy, p = 0.001). Similarly, LAD parameters showed comparable high dose volumes (V40Gy: 21.02% vs 16.26%; p = 0.29) in both groups and a trend toward reduction in mean dose (17.1% vs 9.2%; p = 0.05) in FP IMRT group, although low dose volumes were higher in IP IMRT group. In contralateral breast, doses in smaller volumes were better for FP IMRT plans (V0.5Gy: 59.7% vs 43.8%, p = 0.01; V0.6Gy: 54.07% vs 37.6%, p = 0.007; V1Gy: 40.9% vs 22.1%, p = 0.001; V2Gy: 28.7% vs 9.4%, p = 0.00003; V5Gy: 12.07% vs 4.2%, p = 0.0001). In esophagus, statistically significant lower doses were seen only in terms of Dmean (10.29 Gy vs 5.1 Gy; p = 0.03) with FP IMRT. No significant difference in terms of skin reactions and dysphagia was seen in both the groups. Both IP IMRT and FP IMRT offer benefits and drawbacks, and the superiority of one approach over the other cannot be proved in this study. The decision to choose one approach over another can also be influenced by patient-related criteria such as the risk of loco-regional recurrence vs the danger of radiation-induced sequelae.

These two data sets provide the coefficients of the parameterisation of the (L/L₀)_Opt luminosity-bias factor as a function of the normalized nominal separation, for horizontal and vertical vdM scans, respectively. The data sets are part of a paper with title "Impact of Beam-Beam Effects on Absolute Luminosity Calibrations at the CERN Large Hadron Collider" and are referred thereby as Table 10 and Table 11.

Background: Breast cancer is a systemic disease which has challenged physicians worldwide as it is the most predominant cancer in women often leading to fatality. One of the types of treatment is chemotherapy which includes targeted oral or intravenous cancer-killing drugs. Treatment options are often limited to surgery and/or chemotherapy. Keywords: Breast cancer, docking, estradiol, estrogen receptor α , virtual screening.

Background: Adhesive Capsulitis also named as Periarthritis or Frozen Shoulder is commonly seen in patients of 40 to 60 years of age with a higher incidence in Females.Restricted Gleno-humeral (GH) Joint mobility can be due to micro trauma , osteoarthritis, from prolonged immobilization or from unknown cause (Idiopathic Frozen Shoulder).These lead to various Functional Limitations /Disabilities like -Inability to reach over head activities, behind the head, out to the side and behind the back , thus limiting the Activities of Daily Living . Purpose of the Study:There is a need to compare the efficacy of two treatment techniques in improving the ROM and functional status of the patients with Adhesive Capsulitis.Methodology: 60 patients ,both male and female, of the age group 40-60 years, diagnosed with Adhesive Capsulitis were distributed by Stratified Random Allocation of the Diabetic Patients in 2 groups for a 6 days intervention period.Patients having any recent trauma, injuries, dislocation of shoulder in past 1yr were excluded from the study.The SPADI and ROM were assessed on the first and last day of the intervention.Group A was given Passive Stretching and conventional exercises whereas Group B was given MWM in addition to the conventional exercises.Results: Marked improvement was seen in both the groups after the completion of the 6 days intervention period as compared with the baseline.The improvement in outcome measures , namely the Pain & Disability Score and Range of Motion, were significantly greater in the group who were given Passive Stretching Exercises , p value being 0.00 for Pain, 0.01 for Disability Score and 0.04 for the Total SPADI Score i.e <0.05 indicating its significance .Conclusions: Both groups showed a marked reduction in Pain, Level of Disability, and in improving the ROM of the Shoulder Joint and thereby the overall Function level of the patients having Adhesive Capsulitis.But in the comparative study of the two groups Passive Stretching showed more significant results.

Input to the problem of Load Balanced Network Voronoi Diagram (LBNVD) consists of the following: (a) a road network represented as a directed graph; (b) locations of service centers (e.g., schools in a city) as vertices in the graph and; (c) locations of demand (e.g., school children) also as vertices in the graph. In addition, each service center is also associated with a notion of capacity and an overload penalty which is "charged" if the service center gets overloaded. Given the input, the goal of the LBNVD problem is to determine an assignment where each of the demand vertices is allotted to a service center. The objective here is to generate an assignment which minimizes the sum of the following two terms: (i) total distance between demand vertices and their allotted service centers and, (ii) total penalties incurred while overloading the service centers. The problem of LBNVD finds its application in the domain of urban planning. Research literature relevant to this problem either assume infinite capacity or do not consider the concept of "overload penalty." These assumptions are relaxed in our LBNVD problem. We develop a novel algorithm for the LBNVD problem and provide a theoretical upper bound on its worst-case performance (in terms of solution quality). We also present the time complexity of our algorithm and compare against the related work experimentally using real datasets.

Based on previous experience and attempt, a real-size mosaic Multi-gap Resistive Plate Chamber (MRPC) has been developed within the framework of the CMS muon upgrade efforts. The chamber is a 5-gap with plates made each of 6 pieces of low resistive glass. Cosmic ray test at CERN 904 shows that its efficiency can reach above 95% with a gas mixture of 90% C2H2F4, 5% i-C4H10 and 5% SF6. The chamber was also tested with CMS dry gas(95.2% C2H2F4, 4.5% i-C4H10, 0.3% SF6) at the CERN Gamma Irradiation Facility (GIF++). Efficiency results calculated by a simple tracking method show that the good performance is maintained at rates up to 10 kHz/cm2.

Background: Conformal Radiotherapy techniques adapting to the ballistics of delineated volumes allowed significant reduction in excess radiation induced mortality however the increasing number of long-term survivors and expanding use of cardiotoxic drug highlight the persistent need for maximal cardiac possible sparing. The low dose volume of left ventricle are better predictor of acute coronary events than mean heart dose. Materials and Methods: 38 post-MRM patients were randomized to treatment by 3Dimensional Conformal Radiotherapy (3D CRT) and Intensity Modulated Radiotherapy (IMRT) technique. Two tangential beams were used in 3D CRT technique while five to seven (mostly tangential beams) were used in inversely planned IMRT technique. The dose volume parameters of planning target volume, heart and left ventricle were compared. Results: The dosimetry of Planning target volume showed significantly better coverage in IMRT technique (D90, D95) however the D50 was comparable in both the techniques. In dosimetry of heart, the high dose volumes (V30, V40) were nearly comparable in both the techniques. The other dose volume parameters (V5, V10, V20, V25, D33, D67, D100) and the mean dose were significantly lesser in 3D CRT technique along with significantly better sparing of left ventricle (Dmean and V5). Conclusion: The dosimetry of target volume was better with IMRT technique, but this was accompanied by a huge increase in dose to whole heart and specifically the left ventricle which has strong potential to translate into an increased cardiotoxicity. A better distribution of the target region may be obtained by multiple segmentation of the two tangential fields in 3D CRT plans with further reduction in dose to heart and left ventricle.

This document summarises the talks and discussions happened during the VBSCan Mid-Term Scientific Meeting workshop. The VBSCan COST action is dedicated to the coordinated study of vector boson scattering (VBS) from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

Introduction Radiotherapy has been an important component of the multimodality approach to breast cancer treatment. Newer techniques like three-dimensional radiotherapy had led to better dose distribution over the target volume, with tissue inhomogeneity corrections. To improve the uniformity in dose distribution, a newer technique of intensity modulation was developed, namely, intensity-modulated radiotherapy (IMRT). The present study was designed to compare inverse planned IMRT (IP IMRT) and field-in-field forward planned IMRT (FP IMRT) in patients with breast cancer receiving post-modified radical mastectomy (MRM) adjuvant radiotherapy in terms of dosimetric parameters and clinical outcomes. Materials and methods Fifty patients with breast cancer who have undergone MRM and need adjuvant radiotherapy were randomly assigned in a 1:1 ratio into two groups (25 each) of IP IMRT and FP IMRT techniques. The prescribed dose was 50 Gy in 25 fractions over five weeks. In IP IMRT, five to seven tangential beams were used for the chest wall, nodal volumes were placed at suitable angles with beam optimization, and calculation was carried out by the analytical anisotropic algorithm. For FP IMRT, two opposing tangential fields were created in such a way to achieve uniform dose distribution to the planning target volume (PTV), minimizing hot spot regions, and limiting dose to the ipsilateral lung and contralateral breast. Multiple subfields were manually designed to boost the area not included in the dose cloud. The dosimetric parameters were compared for PTV, lungs, heart, left anterior descending coronary artery (LAD), opposite breast, and esophagus. Results The dosimetric parameters in terms of PTV are better for IP IMRT plans compared to FP IMRT plans (V95%: 92.3% vs 75.2%, p = 0.0001; D90%: 47.4 Gy vs 42.9 Gy, p = 0.0001; D95%: 44.9 Gy vs 37.1, p = 0.0004). The ipsilateral lung (V10Gy: 71.9% vs 41%, p = 0.00001; V20Gy: 42.14% vs 36.35%, p = 0.03; V40Gy: 17.31% vs 26.95%, p = 0.00004; Dmean: 20.91 Gy vs 17.88 Gy, p = 0.01) and contralateral lung (V5Gy: 31.8% vs 0.1%, p < 0.00001; V10Gy: 6.2% vs 0.08%, p = 0.0001) received statistically significant lesser doses in terms of low dose parameters in FP IMRT. In the heart, the dosimetric parameter V5 was significantly lower for FP IMRT (61.7% vs 9.7%, p = 0.00001) along with Dmean (10.92 Gy vs 4.01 Gy, p = 0.001). Similarly, LAD parameters showed comparable high dose volumes (V40Gy: 21.02% vs 16.26%; p = 0.29) in both groups and a trend toward reduction in mean dose (17.1% vs 9.2%; p = 0.05) in FP IMRT group, although low dose volumes were higher in IP IMRT group. In contralateral breast, doses in smaller volumes were better for FP IMRT plans (V0.5Gy: 59.7% vs 43.8%, p = 0.01; V0.6Gy: 54.07% vs 37.6%, p = 0.007; V1Gy: 40.9% vs 22.1%, p = 0.001; V2Gy: 28.7% vs 9.4%, p = 0.00003; V5Gy: 12.07% vs 4.2%, p = 0.0001). In esophagus, statistically significant lower doses were seen only in terms of Dmean (10.29 Gy vs 5.1 Gy; p = 0.03) with FP IMRT. No significant difference in terms of skin reactions and dysphagia was seen in both the groups. Conclusion Both IP IMRT and FP IMRT techniques have advantages and disadvantages, and the superiority of one technique over another cannot be established in this study. The decision for choosing one technique over another can also be based on various patient-related factors weighing the risk of loco-regional recurrences to that of manifesting radiation-induced sequelae.

A new muon reconstruction algorithm is introduced at the CMS experiment. This algorithm reconstructs muons using only the central tracker and the Resistive Plate Chamber (RPC). The aim of this work is to study how a muon reconstructed only with tracker and RPC information would perform compared to the standard muon reconstruction of the CMS detector. The efficiencies to reconstruct and identify a RPC muon with a transverse momentum greater than 20 GeV/c are measured. The probabilities to misidentify hadrons as muons at low transverse momentum are also reported. These probabilities are compared to the standard muon identification used at CMS.

The high parton densities at the Large Hadron Collider lead to a probability of occurrence of two or more parton-parton scatterings in a hadron-hadron collision. The possibility of two hard parton-parton scatterings in a hadron collision is known as double parton scattering (DPS) Double Parton Scattering (DPS) . The study of DPS processes, being performed using the various final states at different collision energies using the CMS detector at the Large Hadron Collider, has been presented. The DPS processes play an important role in hadron-hadron collisions as they act as a backgroundBackground to new physics searches. The study of DPS processes provides information on the parton-parton correlations and parton distributions in a hadron.

This document summarises the talks and discussions happened during the VBSCan Mid-Term Scientific Meeting workshop. The VBSCan COST action is dedicated to the coordinated study of vector boson scattering (VBS) from the phenomenological and experimental point of view, for the best exploitation of the data that will be delivered by existing and future particle colliders.

Abstract The determination of the strong coupling constant $$\alpha _{\mathrm{s}} (m_{\mathrm{Z}})$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>α</mml:mi> <mml:mi>s</mml:mi> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:msub> <mml:mi>m</mml:mi> <mml:mi>Z</mml:mi> </mml:msub> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> from H1 inclusive and dijet cross section data [1] exploits perturbative QCD predictions in next-to-next-to-leading order (NNLO) [2–4]. An implementation error in the NNLO predictions was found [4] which changes the numerical values of the predictions and the resulting values of the fits. Using the corrected NNLO predictions together with inclusive jet and dijet data, the strong coupling constant is determined to be $$\alpha _{\mathrm{s}} (m_{\mathrm{Z}}) =0.1166\,(19)_{\mathrm{exp}}\,(24)_{\mathrm{th}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>α</mml:mi> <mml:mi>s</mml:mi> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:msub> <mml:mi>m</mml:mi> <mml:mi>Z</mml:mi> </mml:msub> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>=</mml:mo> <mml:mn>0.1166</mml:mn> <mml:mspace /> <mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>19</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mi>exp</mml:mi> </mml:msub> <mml:mspace /> <mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>24</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mi>th</mml:mi> </mml:msub> </mml:mrow> </mml:math> . Complementarily, $$\alpha _{\mathrm{s}} (m_{\mathrm{Z}})$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>α</mml:mi> <mml:mi>s</mml:mi> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:msub> <mml:mi>m</mml:mi> <mml:mi>Z</mml:mi> </mml:msub> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math> is determined together with parton distribution functions of the proton (PDFs) from jet and inclusive DIS data measured by the H1 experiment. The value $$\alpha _{\mathrm{s}} (m_{\mathrm{Z}}) =0.1147\,(25)_{\mathrm{tot}}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>α</mml:mi> <mml:mi>s</mml:mi> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:msub> <mml:mi>m</mml:mi> <mml:mi>Z</mml:mi> </mml:msub> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>=</mml:mo> <mml:mn>0.1147</mml:mn> <mml:mspace /> <mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mn>25</mml:mn> <mml:mo>)</mml:mo> </mml:mrow> <mml:mi>tot</mml:mi> </mml:msub> </mml:mrow> </mml:math> obtained is consistent with the determination from jet data alone. Corrected figures and numerical results are provided and the discussion is adapted accordingly.

Double parton scattering is measured in different channels using the CMS experiment at the CERN LHC. Data from pp collisions collected at 7 and 8 TeV center-of-mass energy are used. Several final states are investigated to identify and measure the signature of double parton scattering in inelastic events. Parameters are extracted from the data that are suited in an optimal way to distinguish double parton scattering from various backgrounds. Multivariate analysis techniques are exploited to maximise the sensitivity. Presented at EPS-HEP 2015 European Physical Society Conference on High Energy Physics 2015 Measurement of Double Parton Scattering at LHC with the CMS experiment Ankita Mehta∗† Panjab University, INDIA E-mail: ankita.mehta@cern.ch Double parton scattering is measured in different channels using the CMS experiment at the CERN LHC. Data from pp collisions collected at 7 and 8 TeV center-of-mass energy are used. Several final states are investigated to identify and measure the signature of double parton scattering in inelastic events. Parameters are extracted from the data that are suited in an optimal way to distinguish double parton scattering from various backgrounds. Multivariate analysis techniques are exploited to maximize the sensitivity. The European Physical Society Conference on High Energy Physics 22–29 July 2015 Vienna, Austria ∗Speaker. †On behalf of the CMS collaboration. c © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). http://pos.sissa.it/ Double parton scattering measurements using CMS experiment Ankita Mehta

February 1 th 2013 marked the end of the first period of running of the Large Hadron Collider (LHC) and the start of a two-year break from operation (LS1) aimed at consolidating both the accelerator as well as the detectors. By the end of LS1, the LHC is expected to provide collisions at 13 Tev. While, by 2020, the ultimate instantaneous luminosity is expected to be 1034/cm2/s. To prepare for this scenario, the Resistive Plate Chamber system at the CMS experiment is planning several detector maintainance and consolidation interventions. These include High Voltage and Low Voltage system reparations, gas leak identification and reparation, signal channel connectivity and functionality. Commissioning and upgrade plans for the existing CMS RPC system are presented here.

Charged particles are produced in huge amount in high energy and astro-particle physics experiments such as LHC experiments at CERN, Geneva and in proposed India Based Neutrino Observatory (INO). The identification and measurement of these charged particle set the physics achievable for these experiments. Resistive plate chambers (RPCs), the gaseous detectors which work on the principle of ionization produced in the gaseous medium by fast moving charged particles, are extensively used in detection of charged particles. A laboratory is set-up at Department of Physics, Panjab University for the fabrication and testing of RPC detectors. This paper present the assembly and characterization performance of the fabricated RPCs.

In high energy proton-proton (pp) collisions at LHC, due to the composite nature of protons, it is possible to have two or more distinct hard parton-parton interactions occuring simultaneously in a single pp collision.

The Compact Muon Solenoid is a general purpose detector being operated at Large Hadron Collider facility at CERN. The RE4 (fourth layer of RPC end-cap) upgrade project was envisaged to improve the muon trigger efficiency in the pseudo-rapidity range of 1.2–1.6 for LHC run at energy of 13 TeV and luminosity of $$10^{34}$$ cm $$^{2}$$ s $$^{-1}$$ . A total of 200 Resistive Plate Chambers were built for the upgrade at three assembly sites in Belgium, CERN and India. The assembly and characterization of 50 chambers was carried out jointly by Bhabha Atomic Research Center and Panjab University in India. The gas-gaps from South Korea underwent mechanical tests for leak and popped spacers, followed by electrical tests for leakage currents. Each assembled chamber was characterized by evaluation of efficiency, cluster size, noise and strip profile and are successfuly installed at Compact Muon Solenoid detector.

Hypercalcemia is commonly associated with solid tumor malignancies, but less often with hematologic malignancies. When present in hematologic malignancies, hypercalcemia is often secondary to overproduction of Vitamin D from the tumor cells. Very few cases with parathyroid hormone related peptide (PTHrP) induced hypercalcemia in B-cell lymphomas have been reported. Here we present a 44 year old male with a history of chronic lymphoctic leukemia who presented with hypercalcemia and an elevated PTHrP, found to have a transformation to Diffuse Large B-cell Lymphoma (DLBCL).

In the framework of the High Luminosity LHC upgrade program, the CMS muon group built several different RPC prototypes that are now under test at the new CERN Gamma Irradiation Facility (GIF++). A dedicated Detector Control System (DCS) has been developed using the WinCC-OA tool to control and monitor these prototype detectors and to store the measured parameters data. Preliminary efficiency studies that set the base performance measurements of CMS RPC for starting aging studies are also presented.

Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs.Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually designed sulfone class of compounds.The crystal structure of the inhibited M. leprae InhA complex (2NTV) provides the details of protein-ligand interactions.The virtually designed series of compounds having sulfone moiety have docked well in the active site region of the protein.The prediction of ADME properties was also performed by Qikprop software.Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs.Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually designed sulfone class of compounds.The crystal structure of the inhibited M. leprae InhA complex (2NTV) provides the details of protein-ligand interactions.The virtually designed series of compounds having sulfone moiety have docked well in the active site region of the protein.The prediction of ADME properties was also performed by Qikprop software candidates. INTRODUCTION:Leprosy is an infectious disease caused by an obligate intracellular microorganism, Mycobacterium leprae.Leprosy currently affects approximately a quarter of a million people throughout the world, with the majority of cases being reported from India 1 .

Recent results on the double parton scattering studies and measurement of the underlying event activity, performed using proton-proton collisions data collected using the CMS detector are presented.

Opioids are widely being used for chronic pain management, cough and diarrhea suppressants, anesthetic agents, and opioid de-addiction therapy. Opioid receptors, present in the central nervous system and peripheral tissues, are documented to regulate several cardiac functions through different signaling pathways. Long-acting opioids (LAO) have been successfully evaluated for their beneficial effects in various cardiovascular diseases viz. myocardial infarction, ischemic reperfusion injuries, atherosclerosis etc. However, on the other hand, several research studies pointed towards the harmful effects of LAOs which are mainly associated with QTc prolongation, torsade de pointers, ventricular arrhythmias, and cardiac arrest. This review shall familiarize readers with the benefits as well as the harmful effects of long-acting opioids in cardiovascular diseases. We have also provided an overview of cardiac opioid receptors, endogenous cardiac opioid peptides, and regulation of cardiovascular functions by central and cardiac opioid receptors.

Introduction: The term fibro-osseous is descriptive, nosologically limited and diagnostically non-specific. It is important to appreciate that a histologic diagnosis of fibro-osseous lesion is non-specific and has a limited value in predicting biologic behavior or guiding treatment. A specific diagnosis is important because of the different treatment modalities available for these lesions. Aim: To address the issues pertaining to diagnosis and management of this ambiguous group of lesions and to outline our experience with these lesions. Methods: Forty-one patients who were histologically diagnosed to have a fibro-osseous lesion of the jaw bone in our unit from January 1995 to November 2007 were reviewed for average age, sex incidence, location of the lesion, treatment modalities which included both conservative and surgical methods, and recurrence rates. Conclusion: Fibro-osseous lesions exhibit a variety of clinical behavior and radiological features but share the same microscopic features. Life-long continuous ongoing monitoring of the involved region is required throughout the patient's life.

CMS collaboration is planning to upgrade the forward muon chamber during 2019–2020 to cope up with the High Luminosity LHC (HL-LHC) phase. In the HL-LHC phase the forward region, $$|\eta | \ge $$ 1.5, of CMS detector will face extremely high particle rates in several tens of kHz/cm $$^2$$ and hence it will affect the momentum and longevity of the muon detectors. In concern of above requirement, CMS collaboration is going to install the new large-size, rate-capable Triple Gas Electron Multiplier (GEM) detectors in the forward region of muon system. It will be installed in the GE1/1 region having eta 1.5 $$\le \eta \le $$ 2.2 during LS2 of the LHC. For this the full-size CMS GEM prototype detectors were fabricated and tested under test beam at CERN SPS test beam facility. It was tested with two different gas mixtures Ar/CO $$_2$$ (70/30) and Ar/CO $$_2$$ /CF $$_4$$ (40/15/45). In this paper the results of test beam has been summarized based on time resolution and efficiency.

We will present a summary of results obtained from the study of Standard Model Higgs boson decaying to a pair of W bosons using the CMS detector.

We present recent results on minimum bias collisions, underlying event activity and double-parton scattering using data recorded by the CMS detector at the LHC. The results on the measurement of the underlying event using leading tracks, jets, and Drell-Yan processes are presented. Double-parton scattering is investigated in several final states including vector bosons and multi-jets, and the results are compared to other experiments and to multi-parton interactions models tuned to recent underlying event measurements at CMS.

Introduction: Parsaclisib, a potent, highly selective, next-generation PI3Kδ inhibitor, showed preliminary efficacy as monotherapy for relapsed or refractory non-Hodgkin lymphoma, including DLBCL (Abstract 410, ASH 2017), in a phase 1/2 study. This phase 2 study further assessed parsaclisib in patients with relapsed or refractory DLBCL (NCT02998476). Methods: Patients enrolled into 2 groups (A, Bruton tyrosine kinase [BTK] inhibitor naïve; B, BTK inhibitor experienced) and received oral parsaclisib 20 mg once daily (QD) for 8 weeks, then 20 mg once weekly (QW). In a planned interim futility analysis conducted in the first 40 patients treated in Group A, if ≤13 (≤32.5%) responded by an independent review committee assessment, Group A was to be terminated. Results: At data cutoff (22 Jun 2018), 60 patients (Group A, n = 55; Group B, n = 5) were treated (median age, 71 years [range, 36–94]; men, 63.3%; ≥3 prior systemic therapies, 60%). At the planned interim analysis in Group A, the objective response rate (ORR; by positron emission tomography) was 25% (10/40 patients; 5 complete metabolic response [CMR], 5 partial metabolic response [PMR]); the futility boundary was crossed. At data cutoff, ORR in Group A was 25.5% (14/55 patients; 8 CMR, 6 PMR); median progression-free survival was 2.2 mo (95% CI: 2.0–4.1); median duration of response was 4.5 mo (95% CI: 2.1–5.1). Objective responses were observed in germinal center B-cell (GCB) and non-GCB subtypes. ORR in Group B was 20% (1/5 patients; 1 CMR). The most common non-hematologic treatment-emergent adverse events (TEAEs) occurring in >10% of all patients (all grade [Gr]; Gr 3/4) were rash events (21.7%; 1.7%), colitis/diarrhea events (16.7%; 5.0%), nausea (16.7%; 0%), cough (15%; 0%), and pyrexia (15%; 8.3%). Gr 3/4 aspartate aminotransferase and alanine aminotransferase elevations occurred in 5.0% and 1.7% of patients, respectively; Gr 3/4 neutropenia and anemia occurred in 5.0% of patients each. The most frequent (>5%) serious TEAEs were pyrexia (8.3%), general physical health deterioration (6.7%), and hypercalcemia (6.7%). TEAEs led to therapy discontinuation in 7 patients (2 treatment-related), dose interruption in 20 patients (10 treatment-related), and dose reduction in 3 patients (all treatment-related). Median duration of therapy was 57.5 days (range, 11–318). Conclusion: Parsaclisib monotherapy using a QD followed by QW dosing regimen was well tolerated with no new safety signals reported. Further evaluation of parsaclisib in all subtypes of DLBCL is ongoing in a combination study (NCT03424122). Keywords: diffuse large B-cell lymphoma (DLBCL); non-Hodgkin lymphoma (NHL); PI3K/AKT/mTOR. Disclosures: Belada, D: Research Funding: Celgene. Fay, K: Research Funding: Incyte. Casasnovas, R: Consultant Advisory Role: Roche, Takeda, Gilead, AbbVie, Bristol-Myers Squibb, Merck, Karyopharm; Research Funding: Roche, Gilead, and Takeda. Lee, H: Consultant Advisory Role: MSD and Janssen. Mehta, A: Consultant Advisory Role: Spectrum, Celgene, Kite, BMS; Research Funding: Incyte, Roche, Merck, BMS, Epizyme, Seattle Genetics; Other Remuneration: Gilead, Astra Zeneca, Kite, Spectrum, Kyowa Kirin. Munoz, J: Consultant Advisory Role: Pharmacyclics/Janssen, Bayer, Gilead/Kite, Pfizer, Juno/Celgene, and Bristol-Myers Squib; Other Remuneration: Gilead/Kite, Bayer, Pharmacyclics/Janssen, and AstraZeneca. Corrado, C: Employment Leadership Position: Incyte Corporation; Stock Ownership: Incyte Corporation. DeMarini, D: Employment Leadership Position: Incyte Corporation; Stock Ownership: Incyte Corporation. Zhao, W: Employment Leadership Position: Incyte Corporation; Stock Ownership: Incyte Corporation. Chen, X: Employment Leadership Position: Incyte Corporation; Stock Ownership: Incyte Corporation. Coleman, M: Consultant Advisory Role: Gilead, Bayer, Celgene; Stock Ownership: Kite Pharmaceuticals; Research Funding: Incyte, Gilead, Merck, Bayer, Celgene; Other Remuneration: Gilead, Bayer, Celgene, Pharmacyclics.

This presentation covers the recent measurements on Soft QCD and Forward Physics by CMS experiment.

Primary neuroendocrine tumors of the gall bladder: Morphology with corroborative immunohistochemistry is the key to diagnosis - JDPO- Print ISSN No: - 2581-3714 Online ISSN No:- 2581-3706 Article DOI No:- 10.18231/j.jdpo.2020.001, IP Journal of Diagnostic Pathology and Oncology-IP J Diagn Pathol Oncol

Street children are the most physically visible and vulnerable groups present in the society who live under extreme conditions of the street without care or guidance of parents or any adult.They are portrayed as socially unacceptable with least concerns from the policymakers.This paper explores the concept of street children in Indian context and also evaluates various policies and planning developed in India after its Independence.Further, the paper will explore the importance of childhood concept and the role of anthropologist in it.After evaluating the policies and the concept of street children and childhood, the paper also suggests several models/ approaches that will improve the lives of street children and allows the integration of these children into the mainstream society.

The purposes and possibilities of future diffractive structure function measurements at HERA are presented. A review of the current range and accuracy of the measurement of $F_2^{D(3)}(β, x_p, Q^2)$ is presented and an estimate of the precision of future measurements is given. A feasibility study is performed on the measurement of the structure functions $F_2^{D(4)}(β, x_p, Q^2, t)$, $F_{2 charm}^{D}$, $R^{D(3)}$, $R^{D(4)}$ and $F_L^{p}$. Included in this study are estimates of the integrated luminosity required, the analysis techniques to be employed and values of systematic error that could be expected.