Andreas Albert

Graphene is an outstanding electronic material, predicted to have a role in post-silicon electronics. However, owing to the absence of an electronic bandgap, graphene switching devices with high on/off ratio are still lacking. Here in the search for a comprehensive concept for wafer-scale graphene electronics, we present a monolithic transistor that uses the entire material system epitaxial graphene on silicon carbide (0001). This system consists of the graphene layer with its vanishing energy gap, the underlying semiconductor and their common interface. The graphene/semiconductor interfaces are tailor-made for ohmic as well as for Schottky contacts side-by-side on the same chip. We demonstrate normally on and normally off operation of a single transistor with on/off ratios exceeding 104 and no damping at megahertz frequencies. In its simplest realization, the fabrication process requires only one lithography step to build transistors, diodes, resistors and eventually integrated circuits without the need of metallic interconnects. The realization of wafer-scale graphene electronics is envisaged to open up the route to the use of graphene in mainstream electronics. Hertelet al.take a step in this direction by fabricating a transistor with a SiC channel and graphene electrodes, with excellent performance up to megahertz frequencies.

Dark matter (DM) simplified models are by now commonly used by the ATLAS and CMS Collaborations to interpret searches for missing transverse energy (ETmiss). The coherent use of these models sharpened the LHC DM search program, especially in the presentation of its results and their comparison to DM direct-detection (DD) and indirect-detection (ID) experiments. However, the community has been aware of the limitations of the DM simplified models, in particular the lack of theoretical consistency of some of them and their restricted phenomenology leading to the relevance of only a small subset of ETmiss signatures. This document from the LHC Dark Matter Working Group identifies an example of a next-generation DM model, called 2HDM+a, that provides the simplest theoretically consistent extension of the DM pseudoscalar simplified model. A comprehensive study of the phenomenology of the 2HDM+a model is presented, including a discussion of the rich and intricate pattern of mono-X signatures and the relevance of other DM as well as non-DM experiments. Based on our discussions, a set of recommended scans are proposed to explore the parameter space of the 2HDM+a model through LHC searches. The exclusion limits obtained from the proposed scans can be consistently compared to the constraints on the 2HDM+a model that derive from DD, ID and the DM relic density.

Abstract Memory based on phase change materials is currently the most promising candidate for bridging the gap in access time between memory and storage in traditional memory hierarchy. However, multilevel storage is still hindered by the so-called resistance drift commonly related to structural relaxation of the amorphous phase. Here, we present the temporal evolution of infrared spectra measured on amorphous thin films of the three phase change materials Ag 4 In 3 Sb 67 Te 26 , GeTe and the most popular Ge 2 Sb 2 Te 5 . A widening of the bandgap upon annealing accompanied by a decrease of the optical dielectric constant ε ∞ is observed for all three materials. Quantitative comparison with experimental data for the apparent activation energy of conduction reveals that the temporal evolution of bandgap and activation energy can be decoupled. The case of Ag 4 In 3 Sb 67 Te 26 , where the increase of activation energy is significantly smaller than the bandgap widening, demonstrates the possibility to identify new phase change materials with reduced resistance drift.

Weakly-coupled TeV-scale particles may mediate the interactions between normal matter and dark matter. If so, the LHC would produce dark matter through these mediators, leading to the familiar "mono-X" search signatures, but the mediators would also produce signals without missing momentum via the same vertices involved in their production. This document from the LHC Dark Matter Working Group suggests how to compare searches for these two types of signals in case of vector and axial-vector mediators, based on a workshop that took place on September 19/20, 2016 and subsequent discussions. These suggestions include how to extend the spin-1 mediated simplified models already in widespread use to include lepton couplings. This document also provides analytic calculations of the relic density in the simplified models and reports an issue that arose when ATLAS and CMS first began to use preliminary numerical calculations of the dark matter relic density in these models.

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

This is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3~\mathrm{ab}^{-1}$ of data taken at a centre-of-mass energy of $14~\mathrm{TeV}$, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15~\mathrm{ab}^{-1}$ of data at a centre-of-mass energy of $27~\mathrm{TeV}$. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics.

Hintergrund Die Leberfunktion ist ein prognostischer Faktor bei Patienten mit HCC im Stadium BCLC B/C. Es existiert unzureichend wissenschaftliche Evidenz über die Effektivität von Atezolizumab/Bevacizumab (AB) bei eingeschränkter Leberfunktion und Leberzirrhose Child-Pugh (CP) B.

We conducted a comprehensive review of the current literature of published data, clinical trials (MEDLINE; ncbi.pubmed.com), congress contributions (asco.org; esmo.org), and active recruiting clinical trains (clinicaltrial.gov) on targeted therapies in cholangiocarcinoma. Palliative treatment regimens were analyzed as well as preoperative and perioperative treatment options. We summarized the current knowledge for each mutation and molecular pathway that is or has been under clinical evaluation and discussed the results on the background of current treatment guidelines. We established and recommended targeted treatment options that already exist for second-line settings, including IDH-, BRAF-, and NTRK-mutated tumors, as well as for FGFR2 fusion, HER2/neu-overexpression, and microsatellite instable tumors. Other options for targeted treatment include EGFR- or VEGF-dependent pathways, which are known to be overexpressed or dysregulated in this cancer type and are currently under clinical investigation. Targeted therapy in CCA is a hallmark of individualized medicine as these therapies aim to specifically block pathways that promote cancer cell growth and survival, leading to tumor shrinkage and improved patient outcomes based on the molecular profile of the tumor.

Primary sclerosing cholangitis (PSC) is a serious liver disease associated with inflammatory bowel disease (IBD). Galectin-3, an inflammatory and fibrotic molecule, has elevated circulating levels in patients with chronic liver disease and inflammatory bowel disease (IBD). This study aims to clarify whether galectin-3 can differentiate between patients with IBD, PSC, and PSC-IBD. Our study measured serum galectin-3 levels in 38 healthy controls, 55 patients with IBD, and 22 patients with PSC (11 patients had underlying IBD and 11 patients did not), alongside the urinary galectin-3 of these patients and 18 controls. Serum and urinary galectin-3 levels in IBD patients were comparable to those in controls. Among IBD patients, those with high fecal calprotectin, indicating severe disease, exhibited lower serum and elevated urinary galectin-3 levels compared to those with low calprotectin levels. Serum galectin-3 levels were inversely correlated with C-reactive protein levels. PSC patients displayed higher serum and urinary galectin-3 levels than IBD patients, with the highest serum levels observed in PSC patients with coexisting IBD. There was no correlation between serum and urinary galectin-3 levels and laboratory indicators of liver injury in both IBD and PSC patients. In conclusion, this study demonstrates that serum and urinary galectin-3 levels can distinguish IBD from PSC patients, and also reveals higher serum galectin-3 levels in PSC-IBD patients compared to those with isolated PSC.

We conducted a comprehensive review of the current literature of published data and clinical trials (MEDLINE), as well as published congress contributions and active recruiting clinical trials on targeted therapies in hepatocellular carcinoma. Combinations of different agents and medical therapy along with radiological interventions were analyzed for the setting of advanced HCC. Those settings were also analyzed in combination with adjuvant situations after resection or radiological treatments. We summarized the current knowledge for each therapeutic setting and combination that currently is or has been under clinical evaluation. We further discuss the results in the background of current treatment guidelines. In addition, we review the pathophysiological mechanisms and pathways for each of these investigated targets and drugs to further elucidate the molecular background and underlying mechanisms of action. Established and recommended targeted treatment options that already exist for patients are considered for systemic treatment: atezolizumab/bevacizumab, durvalumab/tremelimumab, sorafenib, lenvatinib, cabozantinib, regorafenib, and ramucirumab. Combination treatment for systemic treatment and local ablative treatment or transarterial chemoembolization and adjuvant and neoadjuvant treatment strategies are under clinical investigation.

Author(s): Albert, Andreas; Backovic, Mihailo; Boveia, Antonio; Buchmueller, Oliver; Busoni, Giorgio; Roeck, Albert De; Doglioni, Caterina; DuPree, Tristan; Fairbairn, Malcolm; Genest, Marie-Helene; Gori, Stefania; Gustavino, Giuliano; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C; Hayden, Dan; Ippolito, Valerio; John, Isabelle; Kahlhoefer, Felix; Kulkarni, Suchita; Landsberg, Greg; Lowette, Steven; Mawatari, Kentarou; Riotto, Antonio; Shepherd, William; Tait, Tim MP; Tolley, Emma; Tunney, Patrick; Zaldivar, Bryan; Zinser, Markus | Abstract: Weakly-coupled TeV-scale particles may mediate the interactions between normal matter and dark matter. If so, the LHC would produce dark matter through these mediators, leading to the familiar mono-X search signatures, but the mediators would also produce signals without missing momentum via the same vertices involved in their production. This document from the LHC Dark Matter Working Group suggests how to compare searches for these two types of signals in case of vector and axial-vector mediators, based on a workshop that took place on September 19/20, 2016 and subsequent discussions. These suggestions include how to extend the spin-1 mediated simplified models already in widespread use to include lepton couplings. This document also provides analytic calculations of the relic density in the simplified models and reports an issue that arose when ATLAS and CMS first began to use preliminary numerical calculations of the dark matter relic density in these models.

Interaktionsarbeit im Bereich personenbezogener (sozialer) Dienste ist von hohem Engagement, aber auch vielen Belastungen geprägt. Inkonsistente wohlfahrtsstaatliche Rahmenbedingungen sorgen systematisch für Spannungen, die das Personal strapazieren und vielfach in Zustände der Zerrissenheit führen. In Fallstudien aus der Altenpflege und der geförderten Weiterbildung demonstrieren die Autor*innen, dass Emotionen hierbei eine kritische Rolle spielen. Sie zeigen zudem, wie diese Zustände darauf einwirken, mit wem sich die Beschäftigten in welcher Weise verbunden fühlen und wie es um deren Widerstandsbereitschaft bestellt ist. Wie die bestehenden Verhältnisse sich ändern ließen, wird anhand sozialpolitischer Alternativen und Veränderungspotenziale durch neue Formen kollektiver Interessenvertretung diskutiert.

Medical mistrust among the public was amplified during the COVID-19 pandemic due to racial and social inequities in infection rates and misinformation in the media. In Boston, two initiatives were launched by the Boston University Clinical Translational Science Institute (BU CTSI), Boston Medical Center (BMC), community health centers (CHCs), and community organizations to establish longitudinal and authentic partnerships with community-research boundary spanners who remained trusted sources of information. Each initiative addressed the immediate need for community-informed and partnered COVID research and provided a structure for longitudinal partnerships. In this paper, we describe the process of envisioning how these two initiatives could move from isolation toward collective impact. We also identify opportunities to improve community-engaged research practices within an academic health system. Our approach provides a structure that other organizations can use to align initiatives and move toward boundary-crossing partnerships which foster health equity.

The electrical properties of the interface between quasi free standing bilayer graphene (QFBLG) and SiC(0001) have been investigated by nanoscale resolution current measurements using conductive atomic force microscopy (CAFM). I-V analyses were carried out on Au-capped QFBLG contacts with different sizes (from 200 down to 0.5 μm) fabricated on SiC samples with different miscut angles (from on-axis to 3.5° off-axis). The extracted QFBLG/SiC Schottky barrier height (SBH) was found to depend on the contact size. SBH values ∼0.9-1 eV were obtained for large contacts, whereas a gradual increase was observed below a critical (micrometer scale) contact size (depending on the SiC miscut angle) up to values approaching ∼1.5 eV. Nanoscale resolution current mapping on bare QFLBG contacts revealed that SiC step edges and facets represent preferential current paths causing the effective SBH lowering for larger contacts. The reduced barrier height in these regions can be explained in terms of a reduced doping of QFBLG from SiC substrate at (11-20) step edges with respect to the p-type doping on the (0001) terraces.

Epitaxial graphene fabricated by thermal decomposition of the Si-face of silicon carbide (SiC) forms a defined interface to the SiC substrate. As-grown monolayer graphene with buffer layer establishes an ohmic interface even to low-doped (e. g. [N] ≈ 10 15 cm -3 ) SiC, and a specific contact resistance as low as ρ C = 5.9×10 -6 Ωcm 2 can be achieved on highly n-doped SiC layers. After hydrogen intercalation of monolayer graphene, the so-called quasi-freestanding graphene forms a Schottky contact to n-type SiC with a Schottky barrier height of 1.5 eV as determined from C-V analysis and core level photoelectron spectroscopy (XPS). This value, however, strongly deviates from the respective value of less than 1 eV determined from I-V measurements. It was found from conductive atomic force microscopy (C-AFM) that the Schottky barrier is locally lowered on other crystal facets located at substrate step edges. For very small Schottky contacts, the barrier height extracted from I-V curves approaches the value of 1.5 eV from C-V and XPS.

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. Based on two concrete examples, we show how existing simplified DM models (SDMM) can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. This discovery scenario uses the recently observed excess in the high-mass diphoton searches of ATLAS and CMS for a case study to show that such a pragmatic approach can aid the experimental search programme to verify/falsify a potential signal and to study its underlying nature. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we discuss important aspects of supersymmetric models for DM and how these could help to develop of more complete SDMM.

Various theoretical aspects of physics beyond the Standard Model at hadron colliders are discussed. Our focus will be on those issues that most immediately impact the projects pursued as part of the BSM group at this meeting.

Dark matter (DM) simplified models are by now commonly used by the ATLAS and CMS Collaborations to interpret searches for missing transverse energy ($E_T^\mathrm{miss}$). The coherent use of these models sharpened the LHC DM search program, especially in the presentation of its results and their comparison to DM direct-detection (DD) and indirect-detection (ID) experiments. However, the community has been aware of the limitations of the DM simplified models, in particular the lack of theoretical consistency of some of them and their restricted phenomenology leading to the relevance of only a small subset of $E_T^\mathrm{miss}$ signatures. This document from the LHC Dark Matter Working Group identifies an example of a next-generation DM model, called $\textrm{2HDM+a}$, that provides the simplest theoretically consistent extension of the DM pseudoscalar simplified model. A comprehensive study of the phenomenology of the $\textrm{2HDM+a}$ model is presented, including a discussion of the rich and intricate pattern of mono-$X$ signatures and the relevance of other DM as well as non-DM experiments. Based on our discussions, a set of recommended scans are proposed to explore the parameter space of the $\textrm{2HDM+a}$ model through LHC searches. The exclusion limits obtained from the proposed scans can be consistently compared to the constraints on the $\textrm{2HDM+a}$ model that derive from DD, ID and the DM relic density.

Im Dezember 2019 begann mit dem Ausbruch der Coronavirus Disease 2019 (COVID-19) eine neue Herausforderung in vielen Bereichen der Medizin und des persönlichen Lebens. Der individuelle Schutz der professionellen Leistungsbringer vor der Infektion wurde zur Sicherung der Leistungsfähigkeit des Gesundheitssystems essenziell. Neue Arbeiten definierten die obere gastrointestinale Endoskopie als aerosolgenerierende Prozedur (AGP), die insbesondere aufgrund des engen Kontakts für das Personal ein erhöhtes Infektionsrisiko darstellt. Da das „severe acute respiratory syndrome coronavirus type 2“ (SARS-CoV-2) in erster Linie durch Aerosole und/oder Tröpfchen übertragen wird, besteht die Notwendigkeit der Verwendung von persönlicher Schutzausrüstung („personal protective equipment“, PPE). Empfehlungen der Leitlinien haben entsprechend früh PPE als infektionspräventive Maßnahmen empfohlen. Die strikte Verwendung von PPE hat sich mit der Erfahrung aus nunmehr 3 Jahren als effektive Präventionsstrategie bewiesen. Mit der Einführung der Vakzinierung gegen SARS-CoV‑2, einer zunehmenden Immunisierung der Bevölkerung und einem sich ändernden pandemischen Infektionsgeschehen haben sich die Anforderungen für endoskopische Abteilungen in den Krankenhäusern und in der ambulanten Versorgung stetig geändert. In der postpandemischen Situation bestehen nur noch geringe Einschränkungen, die die neue „postpandemische Realität“ beeinflussen und die Durchführung endoskopischer Leistungen ohne größere Restriktionen ermöglichen. Die Anpassungen der infektionspräventiven Strategien im Verlauf der Pandemie und die erhobenen wissenschaftlichen Daten mit folgender Anpassung der aktuellen Empfehlungen bis zum heutigen Tag werden in dieser Arbeit zusammengefasst und diskutiert.

Hintergrund Immuncheckpoint-Inhibitoren (ICI) haben in den letzten Jahren die Behandlung gastroenterologisch-onkologischer Erkrankungen revolutioniert. Damit einhergehend hat sich auch das Nebenwirkungsspektrum onkologischer Systemtherapien erweitert. ICI aktivieren die Tumorabwehr über die Unterbrechung inhibitorischer Interaktionen zwischen Antigen-präsentierenden Zellen (APC) und T-Lymphozyten an den sogenannten Immuncheckpoints (u.a. anti-PD-1/PD-L1, anti-CTLA-4) oder durch Stimulation aktivierender Checkpoints. Unerwünschte Ereignisse (AEs) im Zusammenhang mit der Anwendung von ICI werden als immunvermittelte („immune-related“; ir) unerwünschte Ereignisse (irAEs) definiert. Für die Therapie von irAEs liegen entsprechende Handlungsempfehlungen vor: „Management of toxicities from immunotherapy: ESMO Clinical Practice Guideline“; „Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO-Guideline“.

The search for dark matter is one of the main science drivers of the particle and astroparticle physics communities. Determining the nature of dark matter will require a broad approach, with a range of experiments pursuing different experimental hypotheses. Within this search program, collider experiments provide insights on dark matter which are complementary to direct/indirect detection experiments and to astrophysical evidence. To compare results from a wide variety of experiments, a common theoretical framework is required. The ATLAS and CMS experiments have adopted a set of simplified models which introduce two new particles, a dark matter particle and a mediator, and whose interaction strengths are set by the couplings of the mediator. So far, the presentation of LHC and future hadron collider results has focused on four benchmark scenarios with specific coupling values within these simplified models. In this work, we describe ways to extend those four benchmark scenarios to arbitrary couplings, and release the corresponding code for use in further studies. This will allow for more straightforward comparison of collider searches to accelerator experiments that are sensitive to smaller couplings, such as those for the US Community Study on the Future of Particle Physics (Snowmass 2021), and will give a more complete picture of the coupling dependence of dark matter collider searches when compared to direct and indirect detection searches. By using semi-analytical methods to rescale collider limits, we drastically reduce the computing resources needed relative to traditional approaches based on the generation of additional simulated signal samples.

Report of the "Beyond the Standard Model" working group for the Workshop `Physics at TeV Colliders', Les Houches, France, 21 May - 1 June 2001. It consists of 18 separate parts: 1. Preface; 2. Theoretical Discussion; 3. Numerical Calculation of the mSUGRA and Higgs Spectrum; 4. Theoretical Uncertainties in Sparticle Mass Predictions; 5. High Mass Supersymmetry with High Energy Hadron Colliders; 6. SUSY with Heavy Scalars at LHC; 7. Inclusive Study of MSSM in CMS; 8. Establishing a No-Lose Theorem for NMSSM Higgs Boson Discovery at the LHC; 9. Effects of Supersymmetric Phases on Higgs Production in Association with Squark Pairs in the Minimal Supersymmetric Standard Model; 10. Study of the Lepton Flavour Violating Decays of Charged Fermions in SUSY GUTs; 11. Interactions of the Goldstino Supermultiplet with Standard Model Fields; 12. Attempts at Explaining the NuTeV Observation of Di-Muon Events; 13. Kaluza-Klein States of the Standard Model Gauge Bosons: Constraints From High Energy Experiments; 14. Kaluza-Klein Excitations of Gauge Bosons in the ATLAS Detector; 15. Search for the Randall Sundrum Radion Using the ATLAS Detector; 16. Radion Mixing Effects on the Properties of the Standard Model Higgs Boson; 17. Probing Universal Extra Dimensions at Present and Future Colliders; 18. Black Hole Production at Future Colliders.

Die ZSF verfolgt das Anliegen, die wissenschaftlichen Diskurse zu den Phänomenen Bewegung, Spiel und Sport in den Perspektiven von Erziehung, Bildung, Sozialisation und Unterricht zu erschließen und zu fördern. Dafür soll nicht die Festlegung auf ein bestimmtes inhaltliches oder forschungsmethodisches Paradigma bestimmend sein, sondern gedankliche Beweglichkeit, konstruktiver Dialog, fruchtbare Entwicklung und Reflexion von Theorie und Empirie. In das Blickfeld können dabei alle Abschnitte des Lebenslaufs und alle Praxisfelder von Sport- und Bewegungskultur geraten, in denen pädagogische Fragestellungen eine Rolle spielen (z. B. Schulsport, Vereinssport, Selbstorganisierter Sport etc.). Die Vielfalt sportpädagogischer Forschungsthemen und -ausrichtungen soll so – orientiert an wissenschaftlicher Substanz und gesellschaftlicher Relevanz – ein offenes Forum erhalten, Entwicklungen zu beschreiben, zu analysieren und zu erörtern, sie kritisch zu hinterfragen oder auch zukunftsbezogen zu modellieren.

Introduction: To provide appropriate accuracy of CIpc regarding CItd, the manufacturer of the PiCCO suggests recalibration of CIpc by TD after 8 hours. Recently, we developed a calibration index derived from PC parameters indicating a certain probability of a relevant bias of CIpc compared to the next CItd. With changes of CIpc compared to the previous CItd being a key predictor of the bias of CIpc compared to the following CItd, the manufacturer implemented a “trend alarm” indicating absolute changes in CIpc compared to the last CItd (critical thresholds adjustable to 15%, 25% and 35%). Methods: We prospectively evaluated 120 datasets in 32 ICU-patients equipped with the PiCCO-device (Pulsion Medical Systems, Munich, Germany). CIpc-trend alarm was set to 15%. Controls for trend alarm were repeatedly performed after intervals of 30min up to 8h after the initial TD (30min, 60min, 90min...). In case of trend alarm we documented time after last TD, CIpc and its change compared to the last CItd, which is indicated by the device. TD was repeated immediately afterwards to obtain exact CItd. If there was no trend-alarm within 8h, TD was performed after 8h. Primary endpoint: prediction of a >=15% bias of CIpc compared to next CItd by the trend-alarm (yes vs. no). Statistics: Chi-square-test, Spearman correlation; IBM SPSS 21). Results: 32 patients, 13 female, 19 male, mechanical ventilation 65/120 (54.2%) measurements. Among the 120 datasets a total of 52 (43.3%) alarms were recorded within a mean of 4.8+/-2h after the last TD. 11.5%, 27%, 32.7% and 28.8% of the alarms occurred within the 1st, 2nd, 3rd and 4th 2h-interval after the last TD, respectively. The amount of deviation of CIpc compared to CItd was significantly higher in case of trend alarm compared to no trend alarm: 0.72+/-0.67 vs. 0.39+/-0.33 L/min*m2; p<0.001 (absolute bias) and 17+/-14% vs. 8+/-6%; p<0.001 (relative bias). The probability of a bias of CIpc>=15% was significantly higher in case of trend alarm compared to no trend alarm (25/52 vs. 11/68; p<0.001). Sensitivity and specificity of the trend alarm regarding a bias of CIpc >=15% were 69.4% and 67.9%. Accuracy was 82/120 (68.3%). Percentage changes in CIpc compared to baseline CItd indicated by the trend alarm significantly correlated to the bias of CIpc compared to the subsequent CItd (r=0.797; p<0.001). 25/26 increases and 25/26 decreases in CIpc compared to baseline CItd were associated with overestimation and underestimation of the next CItd by CIpc, respectively (accuracy 50/52 (96%)). By contrast, bias of CIpc compared to subsequent CItd was not associated to time after last TD (r=0.638; p=0.67). Conclusions: “15% change in CIpc trend alarm” provided by the new PiCCO algorithm is significantly associated to higher relative and absolute bias-values of CIpc compared to the subsequent CItd. Recalibration of CIpc in case of trend alarm irrespective of the time to last TD might improve the yield of relevant TDs compared to recalibration by a fixed time schedule.

The Model Unspecific Search in CMS (MUSiC) is presented. In MUSiC, proton-proton collision events are sorted into event classes based on final state topology. For each event class, distributions of kinematic variables in data and Monte Carlo simulation of Standard Model physics are automatically compared. The search is explicitly not optimised for any specific model of New Physics to avoid missing phenomena in unexpected topologies. The analysis strategy is applied to the full data set collected at √s = 8 TeV by CMS in 2012 corresponding to an integrated luminosity of 19.5 fb−1. Special emphasis is placed on jet triggered events, which have not previously been considered in the MUSiC analysis. The results of the analysis are presented and discrepancies between data and simulation are studied. A simulation-based sensitivity study is performed to demonstrate the analysis performance for a potential Dark Matter phenomenom.

This is the Snowmass2021 Energy Frontier (EF) Beyond the Standard Model (BSM) report. It combines the EF topical group reports of EF08 (Model-specific explorations), EF09 (More general explorations), and EF10 (Dark Matter at Colliders). The report includes a general introduction to BSM motivations and the comparative prospects for proposed future experiments for a broad range of potential BSM models and signatures, including compositeness, SUSY, leptoquarks, more general new bosons and fermions, long-lived particles, dark matter, charged-lepton flavor violation, and anomaly detection.

Im öffentlichen Diskurs zur Langzeitpflege ist nicht erst seit der Corona-Pandemie von zunehmendem Zeit-, Qualitäts- und Kostendruck die Rede. Für Beschäftigte wachsen die Herausforderungen, ohne dass von der Berufsgruppe – im Unterschied zu anderen Bereichen des Sozialsektors – stärkere Impulse zur Veränderung der Arbeitsbedingungen ausgehen. Der Beitrag argumentiert, dass dies auch mit der Rolle von Gefühlen zu erklären ist, die mit diversen Spannungen bzw. Dilemmata verbunden sind und die Handlungsoptionen der Gruppe beeinflussen. Auf Basis einer Fallstudie aus der ambulanten Pflege wird illustriert, wie institutionelle Vorgaben, Managementpraktiken und individuelle Bewältigungsoptionen in „Emotionsregimes“ führen, die darauf einwirken, wie sich Pflegekräfte mit anderen verbunden fühlen – also welche „Solidaritätshorizonte“ sich bei ihnen in Bezug auf Nutzer*innen, Kolleg*innen und die Gesamtgesellschaft ausbilden. Angesichts des Ineinandergreifens von Emotionsregimes und Solidaritätshorizonten scheint für die Berufsgruppe eine Statusverbesserung aus eigener Kraft eher unwahrscheinlich. Helfen kann nur ein breiterer und substanziellerer gesellschaftlicher Rückhalt.

Searches in CMS for dark matter in final states with invisible particles recoiling against visible states are presented. Various topologies and kinematic variables are explored, including jet substructure as a means of tagging heavy bosons. The focus of the talk is the recent results obtained using data collected at Run-II of the LHC.

Searches for decays of the Higgs boson to invisible particles simultaneously probe the standard model nature of the Higgs sector and the possible existence of DM particle candidates.The ATLAS and CMS Collaborations pursue an ambitious search program for such hypothetical decays in various analysis channels.Using the latest data sets from Run-2 of the CERN LHC (corresponding to approximately 140 fb -1 per experiment), impressive progress has been made in constraining invisible decays of the Higgs boson.In this talk, I present the latest results, discuss their relative importance and summarize the prospects for the near future.

The challenging conditions of the High-Luminosity LHC require tailored hardware designs for the trigger and data acquisition systems. The Apollo platform features a "Service Module" with a powerful system-on-module computer that provides standard ATCA communications and an application-specific "Command Module"s with large FPGAs and high-speed optical fiber links. The CMS version of Apollo will be used for the track finder and the pixel readout. It features up to two large FPGAs and more than 100 optical links with speeds up to 25\,Gb/s. We study carefully the design and performance of the board by using customized firmware to test power consumption, heat dissipation, and optical link integrity. This paper presents the results of these performance tests, design updates, and future plans.

Report of the Beyond the Standard working group for the Workshop `Physics at TeV Colliders', Les Houches, France, 21 May - 1 June 2001. It consists of 18 separate parts: 1. Preface; 2. Theoretical Discussion; 3. Numerical Calculation of the mSUGRA and Higgs Spectrum; 4. Theoretical Uncertainties in Sparticle Mass Predictions; 5. High Mass Supersymmetry with High Energy Hadron Colliders; 6. SUSY with Heavy Scalars at LHC; 7. Inclusive Study of MSSM in CMS; 8. Establishing a No-Lose Theorem for NMSSM Higgs Boson Discovery at the LHC; 9. Effects of Supersymmetric Phases on Higgs Production in Association with Squark Pairs in the Minimal Supersymmetric Standard Model; 10. Study of the Lepton Flavour Violating Decays of Charged Fermions in SUSY GUTs; 11. Interactions of the Goldstino Supermultiplet with Standard Model Fields; 12. Attempts at Explaining the NuTeV Observation of Di-Muon Events; 13. Kaluza-Klein States of the Standard Model Gauge Bosons: Constraints From High Energy Experiments; 14. Kaluza-Klein Excitations of Gauge Bosons in the ATLAS Detector; 15. Search for the Randall Sundrum Radion Using the ATLAS Detector; 16. Radion Mixing Effects on the Properties of the Standard Model Higgs Boson; 17. Probing Universal Extra Dimensions at Present and Future Colliders; 18. Black Hole Production at Future Colliders.

Nach einer Einfuhrung in die Physik des Strahlungstransfers durch Atmosphare und Wasser wird erlautert, welche Anpassungen zu Simulationsrechnungen mit dem Programm HYDROLIGHT fur den Bodensee notwendig sind. Dabei wird besonders auf die charakteristischen Wasserinhaltsstoffe vom Bodensee (Case II-Gewasser) eingegangen und die Rolle der Reflektivitat des Seebodens erlautert. Ergebnisse von Simulationsrechnungen zu bestimmten Situationen werden gezeigt und mit Messungen des Mehrkanal-Spektrometers HYDRA wahrend der Meskampagne 1999 und 2000 verglichen. Anschliesend werden kurz detailiertere Simulationsrechnungen vorgestellt, die das weitere Vorgehen mittels einer Sensitivitatsstudie erlautern. Diese dient als Ausgangspunkt fur die Inversion des Strahlungstransportprozesses, welche notwendig ist zur Auswertung von Fernerkundungsdaten (Flugzeug und/oder Satellit) bezuglich der Gewasseranalyse im Litoral. Im Ausblick werden Verbesserungsmoglichkeiten sowohl in der Mesmethode als auch in der Simulation besprochen.