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DOI: 10.34108/eujhs.1151815
OpenAccess: Closed
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SH-SY5Y NÖROBLASTOMA HÜCRELERİNDE SKOPOLETİN NÖROTOKSİSİTESİNE BAĞLI EMPEDANS DEĞİŞİKLİKLERİNİN GERÇEK ZAMANLI ANALİZİ

Ayşe Kübra Karaboğa Arslan,Aysun Ökçesiz,Leyla Paşayeva

Scopoletin
SH-SY5Y
Cytotoxic T cell
2022
Plant coumarins are important components of the human diet and a number of them are considered to possess chemo-preventive and therapeutic properties against cancer. Scopoletin, a natural coumarin component has been shown to inhibit the growth of many cancer cells. In this study, the cytotoxic activity of scopoletin was studied against human neuroblastoma cells SH-SY5Y. The activity of scopoletin was evaluated by Sulphorhodamine B (SRB) assay and xCELLigence system. It was demonstrated that scopoletin reduced human SH-SY5Y neuroblastoma cell viability. Scopoletin inhibited the growth of the cell line and the IC50 values were 91.82 and 79.19 μM for 48-h and 72-h, respectively. The findings from this study demonstrated that the growth inhibitory and cytotoxic effects of scopoletin on SH-SY5Y cells may prove essential in the development of novel treatment regimens for neuroblastoma cancer.
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    SH-SY5Y NÖROBLASTOMA HÜCRELERİNDE SKOPOLETİN NÖROTOKSİSİTESİNE BAĞLI EMPEDANS DEĞİŞİKLİKLERİNİN GERÇEK ZAMANLI ANALİZİ” is a paper by Ayşe Kübra Karaboğa Arslan Aysun Ökçesiz Leyla Paşayeva published in 2022. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.