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Diversified Treatment Options of Adult Stem Cells for Optic Neuropathies.

Shaoying Tan,Yao Yao,Qichen Yang,Xiang-Ling Yuan,Ling-Ping Cen,Tsz Kin Ng

Neuroprotection
Stem-cell therapy
Optic nerve
Optic neuropathies refer to a group of ocular disorders with abnormalities or dysfunction of the optic nerve, sharing a common pathophysiology of retinal ganglion cell (RGC) death and axonal loss. RGCs, as the retinal neurons in the central nervous system, show limited capacity in regeneration or recovery upon diseases or after injuries. Critically, there is still no effective clinical treatment to cure most types of optic neuropathies. Recently, stem cell therapy was proposed as a potential treatment strategy for optic neuropathies. Adult stem cells, including mesenchymal stem cells and hematopoietic stem cells, have been applied in clinical trials based on their neuroprotective properties. In this article, the applications of adult stem cells on different types of optic neuropathies and the related mechanisms will be reviewed. Research updates on the strategies to enhance the neuroprotective effects of human adult stem cells will be summarized. This review article aims to enlighten the research scientists on the diversified functions of adult stem cells and consideration of adult stem cells as a potential treatment for optic neuropathies in future clinical practices.


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Thrombin Preconditioning Boosts Biogenesis of Extracellular Vesicles from Mesenchymal Stem Cells and Enriches Their Cargo Contents via Protease-Activated Receptor-Mediated Signaling Pathways
DOI: 10.3390/cells8060625
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2019
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Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells
DOI: 10.1002/term.2930
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2019
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Preconditioning with interleukin‐1 beta and interferon‐gamma enhances the efficacy of human umbilical cord blood‐derived mesenchymal stem cells‐based therapy via enhancing prostaglandin E2 secretion and indoleamine 2,3‐dioxygenase activity in dextran sulfate sodium‐induced colitis
DOI: 10.1155/2019/8407206
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2019
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Green Tea Extract Ameliorates Ischemia-Induced Retinal Ganglion Cell Degeneration in Rats
DOI: 10.1002/jcb.29298
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2019
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New strategy of bone marrow mesenchymal stem cells against oxidative stress injury via Nrf2 pathway: oxidative stress preconditioning
DOI: 10.1002/cbf.3423
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2019
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Hypoxic preconditioning improves the survival and neural effects of transplanted mesenchymal stem cells via CXCL12/CXCR4 signalling in a rat model of cerebral infarction
DOI: 10.1089/scd.2019.0060
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2019
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Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma
DOI: 10.1212/wnl.0000000000008394
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2019
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Autologous nonmyeloablative hematopoietic stem cell transplantation for neuromyelitis optica
DOI: 10.1016/j.vetimm.2019.109973
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2020
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Preconditioning of canine adipose tissue-derived mesenchymal stem cells with deferoxamine potentiates anti-inflammatory effects by directing/reprogramming M2 macrophage polarization
DOI: 10.1007/s12015-019-09935-x
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2020
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Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications
DOI: 10.2217/nnm-2019-0208
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2020
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Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair
DOI: 10.1089/cmb.2019.0024
·
2020
Protein Expression Profile on Differentiation of Bone Marrow Mesenchymal Stem Cells into Retinal Ganglion-Like Cells
DOI: 10.1007/s00018-020-03454-6
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2020
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Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy
DOI: 10.1007/s00441-020-03176-y
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2020
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Attenuated regenerative properties in human periodontal ligament–derived stem cells of older donor ages with shorter telomere length and lower SSEA4 expression
DOI: 10.1016/j.cell.2020.03.024
·
2020
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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice
DOI: 10.1056/nejmra1413352
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2015
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Ischemic Optic Neuropathies
DOI: 10.1002/sctm.19-0327
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2020
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Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease
DOI: 10.1167/tvst.9.8.16
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2020
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Systemic Mesenchymal Stem Cell Treatment Mitigates Structural and Functional Retinal Ganglion Cell Degeneration in a Mouse Model of Multiple Sclerosis
DOI: 10.1111/bcpt.13477
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2021
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Complex effect of continuous curcumin exposure on human bone marrow‐derived mesenchymal stem cell regenerative properties through matrix metalloproteinase regulation
DOI: 10.1016/j.stemcr.2020.12.001
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2021
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Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells
DOI: 10.1186/s13287-020-02130-7
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2021
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Human mesenchymal stem cell therapy promotes retinal ganglion cell survival and target reconnection after optic nerve crush in adult rats
DOI: 10.1007/s10633-021-09817-z
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2021
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Retinal function after intravitreal injection of autologous bone marrow-derived mesenchymal stromal cells in advanced glaucoma
DOI: 10.3390/ijms22042117
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2021
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The Benefits and Hazards of Intravitreal Mesenchymal Stem Cell (MSC) Based-Therapies in the Experimental Ischemic Optic Neuropathy
DOI: 10.3390/biom11040581
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2021
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Use of Gene Therapy in Retinal Ganglion Cell Neuroprotection: Current Concepts and Future Directions
DOI: 10.3389/fcell.2021.749131
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2021
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Retinal Stem/Progenitor Cells Derived From Adult Müller Glia for the Treatment of Retinal Degeneration
DOI: 10.1016/s0140-6736(17)31469-1
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2017
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Glaucoma
DOI: 10.1016/j.exer.2022.109159
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2022
Longitudinal and simultaneous profiling of 11 modes of cell death in mouse retina post-optic nerve injury
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