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DOI: 10.1089/ars.2017.7397
OpenAccess: Closed
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Hyperhomocysteinemia Accelerates Acute Kidney Injury to Chronic Kidney Disease Progression by Downregulating Heme Oxygenase-1 Expression

Shuang Li,Bingbing Qiu,Hong Lu,Yunshi Lai,Jixing Liu,Jiajun Luo,Feiqi Zhu,Zheng Hu,Miaomiao Zhou,Jianwei Tian,Zicong Zhou,Yu Song,Fan Yi,Jing Nie

Kidney disease
Hyperhomocysteinemia
Heme oxygenase
2019
Aims: The risk factors promoting acute kidney injury (AKI) to chronic kidney disease (CKD) progression remain largely unknown. The aim of the present study was to investigate whether hyperhomocysteinemia (Hhcy) accelerates the development of renal fibrosis after AKI. Results: Hhcy aggravated ischemia-reperfusion-induced AKI and the subsequent development of renal fibrotic lesions characterized by excessive extracellular matrix deposition. Mechanistically, the RNA binding protein human antigen R (HuR) bound to the 3′-untranslated region (3′-UTR) of heme oxygenase-1 (HO-1) messenger RNA (mRNA). Homocysteine (Hcy) downregulated HuR expression, reduced the binding of HuR to the 3′-UTR of HO-1, and thereafter decreased HO-1 expression. Administration of the HO-1 inducer cobalt protoporphyrin-IX significantly hindered Hhcy-augmented reactive oxygen species production and renal fibrotic lesions. Innovation and Conclusion: These data indicate that Hhcy might be a novel risk factor that promotes AKI to CKD progression. Lowering Hcy level or HO-1 induction might be a potential therapeutic strategy to improve the outcome of AKI.
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    Hyperhomocysteinemia Accelerates Acute Kidney Injury to Chronic Kidney Disease Progression by Downregulating Heme Oxygenase-1 Expression” is a paper by Shuang Li Bingbing Qiu Hong Lu Yunshi Lai Jixing Liu Jiajun Luo Feiqi Zhu Zheng Hu Miaomiao Zhou Jianwei Tian Zicong Zhou Yu Song Fan Yi Jing Nie published in 2019. It has an Open Access status of “closed”. You can read and download a PDF Full Text of this paper here.